Association of estrogen receptor alpha 1 and TMJ dysfunction: A pilot study

Doetzer, Andrea Duarte; Almeida, Luís Eduardo; Camejo, Flavio de Alcântara; Noronha, Lúcia de; Olandoski, Márcia; Trevilatto, Paula Cristina

doi:10.1016/j.oooo.2020.11.010

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…The degeneration of mandibular condylar fibrocartilage cellularity occurs progressively and plateaus at around 50–60 years. Reduced endogenous oestrogen levels in post-menopausal women may be associated with such degenerative TMJ disorders [ 27 ], although advanced age and oestrogen levels did not appear to be as significant as sexual maturation in contributing to the likelihood of a patient developing disc displacement with or without reduction [ 28 , 46 ]. Normal levels of oestradiol in pre-menopause were found to be 100 to 1500 pmol/L but reduced to below 50 pmol/L in post-menopausal women.…”

Section: Discussionmentioning

confidence: 99%

“…In such scenarios, the introduction of exogenous analogues is frequently performed to locally upregulate endogenous corticosteroids and other hormonal imbalances and trigger anti-inflammation [ 24 ]. Other neuroendocrine factors such as somatotrophins, sex hormones, gonadotrophins, thyroid analogues, parathormone, and its hormonal precursors also play a role in shaping the TMJ complex by disrupting proteoglycan synthesis, increasing the frictional mobility of the joint, causing condylar asymmetry, altering the physiologic growth of the TMJ complex, and predisposing patients to degenerative changes and derangement that eventually impair the mobility of the jaw [ 9 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Neuroendocrine Influencers and Associated Factors That Shape Jaw Movement and Growth in Temporomandibular Joint Disorder Management: A Systematic Review of Clinical and Radiographic Evidence

Farook

Dudley

2023

JPM

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Objective. To investigate the influence of endogenous and exogenous neuroendocrine analogues on the range and motion of jaw movement, mandibular growth, and factors affecting condylar guidance in patients with temporomandibular joint disorders using clinical assessment and radiographic imaging. Material and Methods. Eligible articles were extracted from eleven databases in early 2023 and screened following PRISMA protocols. Certainty of evidence and potential biases were assessed using the GRADE approach. Results. Nineteen articles were screened, with four deemed to be of high quality, eight of moderate quality, and the remaining seven of low to very low quality. Corticosteroids improve maximal incisal opening but not TMJ disorder symptoms. Higher doses worsen jaw movement and cause osseous deformity. Growth hormone affects occlusal development, and delayed treatment affects arch width. Sex hormone correlation with TMJ disorder is complex, with some studies showing a correlation between menstrual cycle phases and pain/limited mobility. Conclusions. The evaluation of neuroendocrine influencers in relation to jaw movement in patients with temporomandibular joint disorders involves the complex interplay of potentially confounding factors that each require careful consideration to ensure accurate diagnoses and evaluations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroendocrine Influencers and Associated Factors That Shape Jaw Movement and Growth in Temporomandibular Joint Disorder Management: A Systematic Review of Clinical and Radiographic Evidence

Farook

Dudley

2023

JPM

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“…14,15 Reseptor estrogen wanita akan saling berhubungan dengan sistem hormon yang akan menyelaraskan fungsi metabolik dan menyebabkan lemahnya ligamen pada TMJ. 16 Melemahnya ligamen tersebut akan mengakibatkan gangguan sendi temporomandibula yang memicu gejala-gejala TMD.…”

Section: Pendahuluanunclassified

Gangguan sendi temporomandibular akibat ruang edentulous pada usia dewasa muda Temporomandibular joint disorders due to edentulous spaces in young adults

Lai

Damayanti²,

Wulansari³

2023

Padjadjaran J Dent Res Students

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Pendahuluan: Temporomandibular Disorder (TMD) adalah gangguan yang terjadi pada neuromuskular dan muskuloskeletal yang terjadi akibat disharmoni antara komponen sistem stomatognatik, gigi, dan jaringan di sekitarnya, sehingga dapat mengakibatkan berbagai gangguan yang sering kali ditandai dengan rasa nyeri pada Temporomandibular Join (TMJ) beserta jaringan kompleks disekitarnya. TMD yang disebabkan oleh ruang edentulous pada usia dewasa muda dapat menimbulkan penurunan kualitas hidup seseorang dalam menjalani kegiatan sehari-hari karena sendi temporomandibula merupakan bagian dari sistem stomatognatik yang artinya berhubungan langsung dengan fungsi kerja tubuh dan meliputi tumbuh kembang rahang dan wajah manusia. Tujuan penelitian mengetahui gangguan sendi temporomandibula akibat ruang edentulous pada usia dewasa muda. Metode: Jenis penelitian deskriptif dengan metode cross-sectional. Sampel penelitian adalah mahasiswa preklinik dan klinik Fakultas Kedokteran Gigi Universitas Padjadjaran dengan jumlah 45 orang yang diperoleh menggunakan teknik total sampling. Pengambilan data dilakukan menggunakan kuesioner Temporomandibular Disorder-Index Diagnostic (TMD-ID) dan kuesioner mengenai ruang edentulous. Hasil: Didapatkan jumlah total 45 sampel yang terdiri dari 13 laki-laki (27,95%) dan 32 perempuan (72,05%). Berdasarkan pembagian kategori gangguan sendi temporomandibula akibat ruang edentulous, menghasilkan dua kategori, yaitu TMD positif yang terdiri dari 33 orang (73,33%) dan TMD negatif yang terdiri dari 12 orang (26,67%). Simpulan: Gangguan sendi temporomandibula akibat ruang edentulous pada mahasiswa FKG Universitas Padjadjaran adalah tinggi. KATA KUNCI dewasa muda, gangguan, sendi temporomandibular, edentulous, TMD.

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“…Temporomandibular joint disorder (TMD) is the most common cause of facial pain and influenced by psychosocial factors (such as stress, anxiety, and somatization) 1 , parafunction 2 , and genetic risk factor 3 . Nowadays, there are debates about the role of genetic variation in the onset of TMD and related pain.…”

Section: Introductionmentioning

confidence: 99%

Association of Catechol-O-Methyl-Transferase and Estrogen Receptors polymorphism with Severity of Temporomandibular Disorder in Iranian Patients

Roudgari,

Najafi,

Khalilian

et al. 2023

AJMB

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Background: There are many studies which strongly suggest that the pathophysiology of Temporomandibular joint Disorder (TMD) may also be influenced by genetic conditions. The current study was aimed to evaluate the hypothesis that the polymorphism of estrogen receptor genes, estrogen receptor 1 and 2 (ESR1 and ESR2), and the gene Catechol -O-Methyl-Transferase (COMT) could be Predisposing factor for TMD. Methods: In this case-control study, blood sample were taken from 100 TMD diagnosed patients based on Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and 103 healthy individuals as the control group. Tetra ARMS-PCR method was used to amplify and identify COMT rs4680, ESR1 rs1643821, and ESR2 rs1676303 gene polymorphism. Results: ESR1 genotype AA and GA showed significantly increase probability (OR= 4.80, OR=2.98, respectively) of TMD. ESR2 T/T homozygosity was associated with decreased risk for TMD (OR=0.41). The relationship between COMT and TMD was not statistically significant (p>00.05). The relationship between the severity of TMD and ESR1 was significant (p=0.003). According to the inheritance pattern the COMT and ESR1 gene, in the dominant pattern can be susceptible to TMD and in ESR2 gene, in the recessive pattern can be protective to TMD. Conclusion: It seems that SNPs of ESR1 rs1643821 has a susceptible role and ESR2 rs1676303 has a protective role against TMD. Also, we add evidences that various genotype of COMT rs4680 were not statistically different between case and control, but allele A in the dominant inherence pattern can be susceptible to TMD.

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Association of estrogen receptor alpha 1 and TMJ dysfunction: A pilot study

Cited by 5 publications

References 15 publications

Neuroendocrine Influencers and Associated Factors That Shape Jaw Movement and Growth in Temporomandibular Joint Disorder Management: A Systematic Review of Clinical and Radiographic Evidence

Neuroendocrine Influencers and Associated Factors That Shape Jaw Movement and Growth in Temporomandibular Joint Disorder Management: A Systematic Review of Clinical and Radiographic Evidence

<p><strong> Gangguan sendi temporomandibular akibat ruang edentulous pada usia dewasa muda</p></strong><em/><p><strong> Temporomandibular joint disorders due to edentulous spaces in young adults</p></strong>

Association of Catechol-O-Methyl-Transferase and Estrogen Receptors polymorphism with Severity of Temporomandibular Disorder in Iranian Patients

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