A cross sectional study conducted during the period from February 2011 to April 2012 to determine and to evaluate the serum levels lipid profile, creatinine and HbA 1c in Sudanese patients with type 2 diabetes mellitus associated with obesity. Two hundred Sudanese with type 2 diabetes mellitus associated with obesity were selected as a test group from Khartoum, Omdurman and Khartoum North hospitals in Khartoum state, Sudan. The test group was compared with a control group, which included 100 apparently healthy volunteers. Blood specimens were collected from both groups, and the serum levels of lipid profile (total cholesterol, triglycerides, high density lipoprotein cholesterol (HDL C ) and lowdensity lipoprotein cholesterol (LDL C ), in addition to fasting plasma glucose (FPG) and creatinine and glycated hemoglobin (HBA 1C ) were determined. Age and gender of the test group were matched with the control group. The serum levels of plasma glucose, total cholesterol, HDL C , LDL C, triglycerides, creatinine and Hba 1C were measured using spectrophotometer methods. Statistical Package for Social Science (SPSS version 11.5) computer software was used for data analysis. The results of this study indicated significantly raised means of the serum levels of total cholesterol, LDL C, triglycerides and creatinine of the test group when compared with the control group, whereas the mean of the serum levels of HDL C of the test group showed a significant reduction when compared with the control group. The results of this study also indicates a significant elevation of the means of the serum levels of total cholesterol, LDL C, triglycerides and creatinine among diabetic patients with ischemic heart disease when compared with those without ischemic heart disease, whereas the mean of the serum levels of HDL C among diabetic patients with ischemic heart disease shows a significant reduction when compared with those without ischemic heart disease. The means of the serum levels of total cholesterol, LDL C, triglycerides and creatinine among diabetic patients with hypertension or having renal insufficiency were significantly raised when compared with those without these diseases. Whereas the means of the serum levels of HDL C among diabetic patients with hypertension or having renal insufficiency were found to be significantly decreased when compared with those without these diseases. The results of the current study shows a significant moderate positive correlation between the duration of diabetes (in years) and the serum levels of total cholesterol, LDL C, triglycerides and creatinine ,whereas there is a significant moderate negative correlation between the duration of diabetes (in years) and the serum levels of HDL C , and shows a significant strong positive correlation between the duration of diabetes and the serum levels of creatinine. This study shows insignificant weak positive correlations between Hba 1C and the serum levels of total cholesterol, LDL C, triglycerides and creatinine and insignificant weak negative correlation...