Association of echocardiographic left ventricular structure with the ACE D/I polymorphism: a meta-analysis

Jin, Yu; Kuznetsova, Tatiana; Thijs, Lutgarde; Richart, Tom; Stolarz‐Skrzypek, Katarzyna; Liu, Yanping; Fagard, Robert; Manunta, Paolo; Bianchi, Giuseppe; Staessen, Jan A.

doi:10.1177/1470320310387178

Cited by 10 publications

(6 citation statements)

References 78 publications

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“…However, the relationship to cardiac pathology is still controversial. Similar to the present study, the ventricular function abnormality determined by EKG was proposed for interrelationship with ACE polymorphism by Yu Jin et al 4 . Nevertheless, the small sample size in the published studies 1,4 is the main obstacle for conclusions.…”

supporting

confidence: 85%

“…Similar to the present study, the ventricular function abnormality determined by EKG was proposed for interrelationship with ACE polymorphism by Yu Jin et al 4 . Nevertheless, the small sample size in the published studies 1,4 is the main obstacle for conclusions. The effect of race in clinical relationship of ACE polymorphism requires a very large study in order to lead to conclusions 2 .…”

supporting

confidence: 85%

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Angiotensin-converting Enzyme Genetic Polymorphism

Wiwanitkit¹,

Wiwanitkit²

2014

Arquivos Brasileiros De Cardiologia

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supporting

confidence: 85%

supporting

confidence: 85%

Angiotensin-converting Enzyme Genetic Polymorphism

Wiwanitkit¹,

Wiwanitkit²

2014

Arquivos Brasileiros De Cardiologia

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“…Yu’s method was used to calculate the mean standardized difference, which was used to assess inter-group differences independent of the unit of measurement. 4,14…”

Section: Methodsmentioning

confidence: 99%

“…Between 30% and 70% of the population variability in LVH appears to be genetically determined. 4–6 In this way, focusing on the specific genes that influence quantitative variation in left ventricular structure is merited, and the findings may generate insights into the pathogenesis of cardiac hypertrophy. The renin-angiotensin-aldosterone system (RAAS) has been shown to influence myocardial growth independently of hypertension, and it has been speculated that the polymorphisms of genes coding this system may explain the heritability of LVH.…”

Section: Introductionmentioning

confidence: 99%

Association of echocardiographic left ventricular structure and −344C/T aldosterone synthase gene variant: A meta-analysis

Wang

Zhou

Zhang

et al. 2014

J Renin Angiotensin Aldosterone Syst

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Background: Aldosterone synthase (CYP11B2) is one of the most studied candidate genes related to essential hypertension (EH) and left ventricular hypertrophy (LVH). Some studies have focused on the relationship between −344C/T polymorphism (rs1799998) in the CYP11B2 gene and LVH, but the results are controversial. This meta-analysis is purposed to reveal the relationship between the −344C/T and the left ventricular structure and function, including left ventricular end diastolic dimension (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular mass/left ventricular mass index (LVM/LVMI), left ventricular posterior wall thickness (LVPWT), and interventricular septal wall thickness (IVS). Methods: A literature search of PubMed and Embase databases was conducted on articles published before January 27, 2014. The odds ratios with 95% confidence intervals were calculated. Heterogeneity analyses were performed using meta-regression. Tests for publication bias were also performed and biased studies should be removed from subsequent analyses. Results: There were 20 studies with a total of 6780 subjects meeting the inclusion criteria. The main finding was that concentration levels of LVEDD and LVESD were higher in CC homozygous individuals than in TT homozygous individuals in the whole group. In the Asian subgroup, TT homozygous individuals had larger IVS than CC homozygous individuals. In the Caucasian normotension subgroup, CC homozygous individuals had larger LVM/LVMI than TT homozygous individuals. In the Asian essential hypertension subgroup, TT homozygous individuals had larger LVPWT values than CC homozygous individuals. Conclusions: The present findings support the hypothesis that CC homozygous individuals may have greater left ventricular diameters (LVEDD and LVESD) regardless of their ethnicities or physical conditions.

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“…In relation to the association between the ACE I/D polymorphism and TOD in hypertensive individuals, the current research shows that individuals with the DD genotype had an almost fivefold higher risk for LVH compared to those with the II genotype, a condition reported by previous studies [ 10 , 11 ]. Recently, two meta-analyses demonstrated an association between the ACE I/D polymorphism and LVH [ 20 , 48 ]. However, other authors did not confirm this association [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion polymorphism, 24-h blood pressure profile and left ventricular hypertrophy in hypertensive individuals: a cross-sectional study

et al. 2015

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BackgroundThe absence of nocturnal blood pressure dipping (ND) identified by 24-h ambulatory blood pressure monitoring (ABPM) correlates with a worse cardiovascular prognosis. The renin–angiotensin system influences blood pressure levels and the occurrence of target organ damage (TOD). Thus, the aim of this study was to correlate the angiotensin-converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism with the 24-h blood pressure profile and TOD in hypertensive individuals.Methods155 non-diabetic hypertensive individuals on antihypertensive treatment underwent ABPM. Peripheral blood samples were drawn for biochemistry and genetic analysis of the ACE I/D polymorphism by polymerase chain reaction. ND was defined as ≥10 % differences in the mean systolic blood pressure (BP) during wakefulness and sleep.ResultsThere were no differences in clinical or biochemical variables or TOD in respect to ND status, except for higher BP levels during sleep (p < 0.001) in non-dippers. There was significant difference in the prevalence of left ventricular hypertrophy (LVH) between ACE genotypes (II: 13.0 %; ID: 34.1 %; DD: 46.5 %; p value = 0.024) with an increased risk in carriers of the DD genotype (OR = 5.80; IC 95 % 1.50–22.44; p value = 0.011). Carriers of the D allele had higher systolic BP during wakefulness and by ABPM (p < 0.05), higher left ventricular mass (117.3 ± 50.0 vs. 100.3 ± 25.7; p value = 0.017) and higher prevalence of LVH (37.4 vs. 12.5 %; OR = 4.14; 95 % IC: 1.17–14.65; p value = 0.028), compared to the II genotype.ConclusionsThe DD genotype is associated with a higher prevalence of LVH. The presence of the D allele appears to be associated with higher mean 24-h and wake systolic BP measured by ABPM in hypertensive patients under antihypertensive treatment.

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Association of echocardiographic left ventricular structure with the ACE D/I polymorphism: a meta-analysis

Abstract: : Our meta-analysis supports the hypothesis that the enhanced ACE activity associated with the D allele is associated with higher LV mass. Smaller sample size might explain the lack of significant association with LVH.

Cited by 10 publications

References 78 publications

Angiotensin-converting Enzyme Genetic Polymorphism

Angiotensin-converting Enzyme Genetic Polymorphism

Association of echocardiographic left ventricular structure and −344C/T aldosterone synthase gene variant: A meta-analysis

Angiotensin-converting enzyme insertion/deletion polymorphism, 24-h blood pressure profile and left ventricular hypertrophy in hypertensive individuals: a cross-sectional study

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