Association of echocardiographic left ventricular structure and −344C/T aldosterone synthase gene variant: A meta-analysis

Wang, Limin; Zhou, Jun; Zhang, Bei; Wang, Hao; Li, Mei; Niu, Qiuli; Chen, Runsheng; Wen, Shaojun

doi:10.1177/1470320314535459

Cited by 5 publications

(3 citation statements)

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“…The associations of larger EDD with the presence of C allele and larger PWD with TT presence were described earlier in a meta-analysis of WangL. et al 11 . Therefore, our data are in agreement with modern views in this field.…”

Section: Discussionsupporting

confidence: 53%

“…The data on CYP11B2 polymorphism prevalence in our study was similar to the studies completed in Ukraine and other countries, where the Caucasian populations such as Germany, Finland, Czech Republic, USA, and Uzbekistan were tested [3][4][5][6][7] . But they were different from orient countries (Japan, China, and Tibet) [8][9][10][11] by the prevalence of CC genotype. The associations of larger EDD with the presence of C allele and larger PWD with TT presence were described earlier in a meta-analysis of WangL.…”

Section: Discussionmentioning

confidence: 76%

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Left ventricle geometry, echoreflectivity and CYP11B2 polymorphism C-344T in hypertensive males

2019

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Objectives: Hypertensive heart remodeling requires the assumption of different factors, including an increase of left ventricular mass (LVM) and myocardial fibrosis. It was shown that aldosterone stimulates cardiac collagen synthesis and fibroblast proliferation. CYP11B2 is one of the genes responsible for the effects of aldosterone. Therefore, hypertensive remodeling could be partially related to the polymorphism of this gene. The purpose of this study was to assess the association of CYP11B2 polymorphism with structural remodeling by changes in geometry and myocardial density to define their role and interaction in hypertensive heart disease. Methods: The study recruited 150 men aged 45-60 with and without essential hypertension (EH), who possessed no irreversible target organ damages. Fifty of them had normal BP, 58 had EH without left ventricular hypertrophy (LVH) and 42 had EH and LVH. Each participant underwent office blood pressure measurement, echocardiography with echo-reflectivity analysis, and determination of the C-344T polymorphism of the aldosterone synthase gene CYP11B2. Results: Patients with EH and LVH differed not only by LV mass but also by larger body mass, relative wall thickness, and wider echo-reflectivity spectrum. The associations of larger end diastolic diameter with C allele, and the larger thickness of the posterior wall and interventricular septum with T allele, were revealed only in patients with EH and LVH. Conclusions: Hypertensive patients with LVH are likely to be a distinct cluster with their own genetic predisposition to hypertensive heart disease.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 76%

Left ventricle geometry, echoreflectivity and CYP11B2 polymorphism C-344T in hypertensive males

2019

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“…В экспериментальных исследованиях установлен выраженный профибротический эффект альдостерона и его влияние на развитие гипертрофии миокарда вне зависимости от уровня артериального давления и объема циркулирующей крови. При этом также отмечено его влияние, обусловленное избыточной локальной экспрессией минералокортикоидных рецепторов в кардиомиоцитах [13,14]. Результаты крупного рандом изированного исследования DIAST-CHF показали взаимосвязь риска развития ДДЛЖ с повышением уровня альдостерона, которая была более выраженной у женщин и оставалась значимой после учета таких факторов, как уровень ренина в плазме, АГ, принимаемая терапия, СД, индекс массы тела и функции почек [15].…”

Section:  результаты и обсуждениеunclassified

Особенности С(-344)т Полиморфизма Гена Альдостеронсинтазы CYP11B2 У Пациентов С Хронической Сердечной Недостаточностью

Nuritdinov¹,

Kamilova²,

Хамраев³

2021

Кардиология В Беларуси

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Цель. Изучить особенности С(-344)Т полиморфизма гена CYP11B2 у пациентов с хронической сердечной недостаточностью (ХСН) с диастолической дисфункцией левого желудочка (ДДЛЖ). Материалы и методы. Обследовано 215 пациентов с ишемической болезнью сердца (ИБС) с I-III (функциональным классом) ФК ХСН (согласно классификации Нью-Йоркской ассоциации кардиологов). Всем пациентам проводили комплексное клиническое обследование, тест шестиминутной ходьбы (ТШХ), эхокардиографию (ЭхоКГ) с доплерографией, оценку клинического состояния по шкале оценки клинического состояния (ШОКС). Молекулярно-генетические исследования методом ПЦР проводились 134 пациентам с ХСН и 102 лицам узбекской национальности. Результаты. У 73,9% пациентов с ХСН наблюдалось ухудшение диастолической функции ЛЖ, свидетельствовавшее о прогрессировании заболевания. При этом нарушения диастолической функции ЛЖ в большей степени характеризовались ухудшением релаксации, а с прогрессированием заболевания - развитием рестриктивного типа ДДЛЖ. Выявлена зависимость между носительством гомозиготного генотипа Т/Т полиморфизма rs1799998 гена CYP11B2 и повышением риска формирования рестриктивной формы ДДЛЖ в два раза (χ2=1,8; Р=0,02; OR=1,8; 95% CI: 0,75-4,54), что позволяет предполагать прогностическую роль данного генотипического варианта в повышении риска развития рестриктивной формы ДДЛЖ при ХСН. Заключение. Установлена зависимость между носительством гомозиготного генотипа Т/Т полиморфизма rs1799998 гена CYP11B2 и повышением риска формирования рестриктивной формы ДДЛЖ. Purpose. To study the features of the C(-344)T polymorphism of the CYP11B2 (rs1799998) aldosterone synthase gene in chronic heart failure (CHF) patients with left ventricular diastolic dysfunction (LVDD). Materials and methods. A total of 215 patients with coronary heart disease (IHD) with I-III functional class (FC) CHF (New York Heart Association classification) were examined. All patients underwent a comprehensive clinical examination, six-minute walk test (SMWT), echocardiography (EchoCG). 134 patients with CHF and 102 persons of Uzbek nationality underwent molecular genetic studies by PCR. Results. In 73.9% of patients with CHF, the impaired LV diastolic function was observed, characterized by its deterioration with the progression of the disease. At the same time, the impaired LV diastolic function was characterized to a greater extent by impaired relaxation, and with the progression of the disease - a restrictive type of LVDD impairment. There was revealed the dependence between the carriage of the homozygous genotype T/T of the rs1799998 polymorphism of the CYP11B2 gene and almost two-fold increase of the risk of formation of a restrictive form of CHF (χ2=1.8; P=0.02; OR=1.8; 95% CI: 0.75-4.54), which allows us to make an assumption, in relation to this genotypic variant, about its prognostic role in increasing the risk of development of this form of LVDD in CHF. Conclusion. The relationship was revealed between the carriage of the homozygous T/T genotype of the rs1799998 polymorphism of the CYP11B2 gene and the increased risk of the formation of restrictive form of LVDD.

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Association of the −344T/C polymorphism in aldosterone synthase gene promoter with left ventricular structure in Chinese Han: A meta-analysis

Yin

Gao

et al. 2017

Clinical and Experimental Hypertension

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No consensus view has been published on the relationship between the aldosterone synthase gene (CYP11B2) -344C/T polymorphism and left ventricular hypertrophy (LVH) in Chinese Han. We undertook a meta-analysis to investigate the potential association of this polymorphism and left ventricular structure-related phenotypes, including left ventricular mass (LVM), left ventricular mass index (LVMI), left ventricular end systolic diameter (LVESD), left ventricular end diastolic dimension (LVEDD), left ventricular posterior wall thickness (LVPWT), and interventricular septal wall thickness (IVS). Studies in English and Chinese were found based on a systematic search of Medline, Embase, CNKI, and Wanfang databases. The dominant model (TT vs. TC+CC) and homozygote model (TT vs. CC) were selected to examine the association between the -344C/T polymorphism and LVH. The random-effects model was used to pool data. From a total of 3104 participants, despite the investigation of six echocardiographic indicators, we found no significant association between the -344C/T variant and LVH in the whole group and the subgroup analyses by blood pressure. However, in the subgroup of northern Han Chinese, TT genotype had higher LVPWT than CC genotype and TC genotype (p = 0.4, p = 0.04, 95% CI 0.09 (0.00, 0.18)). In addition, no evidence of publication bias was observed. In conclusion, our meta-analysis indicated that subjects with TT genotype might have higher risk of developing LVH in northern Han Chinese.

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Association of echocardiographic left ventricular structure and −344C/T aldosterone synthase gene variant: A meta-analysis

Cited by 5 publications

References 46 publications

Left ventricle geometry, echoreflectivity and CYP11B2 polymorphism C-344T in hypertensive males

Left ventricle geometry, echoreflectivity and CYP11B2 polymorphism C-344T in hypertensive males

Особенности С(-344)т Полиморфизма Гена Альдостеронсинтазы CYP11B2 У Пациентов С Хронической Сердечной Недостаточностью

Association of the −344T/C polymorphism in aldosterone synthase gene promoter with left ventricular structure in Chinese Han: A meta-analysis

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