Association of the −344T/C polymorphism in aldosterone synthase gene promoter with left ventricular structure in Chinese Han: A meta-analysis

Yin, Chengqian; Gu, Weijun; Gao, Yun; Zhao, Li; Chen, Xuanzu; Li, Zhizhong; Wen, Shaojun

doi:10.1080/10641963.2017.1291660

Cited by 4 publications

(7 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…indicated that −344C/T polymorphism might be associated with CAD in Caucasian and Asian populations. 8 However, Mishra et al. 26 indicated that the −344C/T polymorphism in CYP11B2 is not correlated with CAD or left ventricular hypertrophy in an Indian population, although that study did not involve stratification by sex.…”

Section: Discussionmentioning

confidence: 98%

“…25 In a metaanalysis, Yin et al indicated that À344C/ T polymorphism might be associated with CAD in Caucasian and Asian populations. 8 However, Mishra et al 26 indicated that the À344C/T polymorphism in CYP11B2 is not correlated with CAD or left ventricular hypertrophy in an Indian population, although that study did not involve stratification by sex. In addition, a prospective study of healthy British men discovered that the À344C/T variant is not associated with cardiovascular risk.…”

Section: Discussionmentioning

confidence: 98%

“…A meta-analysis of 7,710 subjects reported a lack of an association between the polymorphism and ischemic stroke. 8 , 17 In 2015, another meta-analysis indicated that the −344C/T variant was significantly associated with ischemic stroke, and subgroup analysis showed that it was significantly associated with ischemic stroke in East Asian and South Asian populations, but not in a Caucasian population. 30 Presently, the CYP11B2 −344C/T polymorphism could influence susceptibility to ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

“…10,11 We found that the À344C allele is strongly associated with increased left ventricular size and decreased baroreflex sensitivity in healthy individuals; these physiological parameters are cardiovascular risk factors. 8,12 Nevertheless, one report suggested that rs1799998 is not associated with hypertension or other cardiovascular indicators in a population in Thailand. 13 Recent population-based studies established the association of the À344C/T CYP11B2 polymorphism with the risk of cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

“…The most studied is the rs1799998 C/T single nucleotide polymorphism (SNP), also referred to as “−344” because of its base position relative to the gene transcription start site. 8 , 9 At the molecular level, the role of the CYP11B2 locus has been extensively evaluated in cardiovascular disease, with particular attention to the −344C/T SNP. Previous studies also identified variants of CYP11B2 associated with increased risk of EH.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Association of −344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension

et al. 2020

View full text Add to dashboard Cite

Objective Several recent studies have shown that the aldosterone synthase gene ( CYP11B2) −344C/T polymorphism is related to cardiovascular diseases. However, whether the −344C allele influences the incidence of cardiovascular diseases in Chinese patients with hypertension is unclear. Methods Chinese patients with essential hypertension were genotyped for the −344C/T polymorphism in CYP11B2 (n = 755; CC, n = 112; CT, n = 361; TT, n = 282) and followed for 11 years for major adverse cardiovascular events (MACEs), including stroke, onset of coronary artery disease (CAD), and CAD-related death. Established cardiovascular risk factors were used to adjust the multivariate Cox analysis. Results After a mean follow-up period of 7.60 ± 1.12 years, a significantly higher incidence of MACEs was seen in patients with the CC genotype than in those with the CT and TT genotypes. The CC variant was significantly and independently predictive of MACEs (hazard ratio = 2.049), CAD (hazard ratio = 1.754), and stroke (hazard ratio = 2.588), but not CAD-related stroke or death. Conclusion The CYP11B2 −344 CC genotype is a risk factor for CAD and stroke, independent of other established cardiovascular risk factors in Chinese patients with hypertension.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Association of −344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension

et al. 2020

View full text Add to dashboard Cite

show abstract

Associations of excess myocardial mass, echoreflectiveness and aldosterone synthase gene polymorphism in men with hypertension

Osovska

Lozinska

Lozinsky

et al. 2021

Biomed. and Biosoc. Anthrop.

View full text Add to dashboard Cite

Hypertensive remodeling of the left ventricle (LV) is largely due to the influence of a number of control genes. In particular, the regulatory gene CYP11B2, which is responsible for the activity of aldosterone in blood plasma, affects the processes of cardiomyocyte hypertrophy, myocardial fibrosis and microcirculation. This study is devoted to the search for the effect of polymorphic aldosterone synthase carriers on the severity of the components of left ventricular hypertrophy in men with essential hypertension (EH) and representatives of the control group, residents of Podyllia region. The aim of the study was to determine associations between excess (inappropriate) myocardial mass, parameters of standard echocardiography and parameters of echoreflectivity in men with essential hypertension, carriers of different polymorphic variants of aldosteronesynthase gene. The study involved 150 men, aged 45-60 years, residents of the Podyllia region, who had no irreversible damage of target organs. Among them, 50 were in the control group, 58 – had EH of 1st stage and 42 men had EH of 2nd stage. All participants were measured for office blood pressure, performed a standard echocardiographic examination with the addition of standard EchoCG protocol by determination of the parameters of echoreflectivity and evaluation of appropriateness of left ventricular l mass (LVM) to hemodynamic load, according to the formula de Simone et al. and calculating the excessiveness ratio (ER) and determined the C-344T polymorphism of the CYP11B2 gene in venous blood samples by PCR. Statistical processing of the obtained results is performed using a specialized statistical application “Statistica 12.0”. It was found that the prevalence of CC polymorphism of the CYP11B2 gene in men with inappropriate LVM was almost twice higher than in men with appropriate to hemodynamic load LVM (p=0.015 by criterion χ2). At the same time, men with inappropriate LVM were characterized by higher values of echoreflectivity parameters BB and mCSV. In contrast to patients of the control group and patients with EH of 1st stage, patients with EH of 2nd stage, actual LVM (287.4 (53.9) g) significantly (p<0.001) exceeded the predicted values (189 (37.8) g). According to the results of Spearman's rank correlation analysis, it was found that the carrier of the CC genotype of aldosterone synthase gene is associated with higher values of the LVM ER. Thus, patients carrying the polymorphic CC variant of CYP11B2 gene are characterized by more pronounced cardiomyocyte hypertrophy, greater excess of LV mass relative to individual hemodynamic needs, more aggressive processes of myocardial fibrosis.

show abstract

Прогнозирование Риска Развития Гипертрофии Левого Желудочка При Артериальной Гипертензии С Учетом Полиморфизма Генов Ренин-Ангиотензинальдостероновой Системы

Павлова¹,

Ogurtsova²,

Денисевич³

et al. 2021

Кардиология В Беларуси

View full text Add to dashboard Cite

Цель. Определить клинико-генетические факторы риска прогрессирования гипертрофии левого желудочка (ГЛЖ) с учетом полиморфизма генов ренин-ангиотензин-альдостероновой системы (РААС) по данным проспективного пятилетнего наблюдения пациентов с эссенциальной артериальной гипертензией (АГ). Материалы и методы. Клинико-инструментальное обследование выполнено у 155 пациентов с АГ, из них 82 мужчины и 73 женщины (средний возраст 54,5±9,4 года). Признаки ГЛЖ оценивались при эхокардиографии (ЭхоКГ) с расчетом индекса массы миокарда левого желудочка (ИММЛЖ). Генотипирование полиморфных локусов генов ренин-ангиотензин-альдостероновой системы (РААС), I/D ангиотензинпревращающего фермента (АСЕ), М235Т ангиотензиногена (AGT), G83A ренина (REN), C(-344)T альдостеронсинтазы (СYP11B2), A1166C рецепторов кангиотензину II 1-го типа (AGTR1) и 2-го типа C3123A (AGTR2) проводилось методом полимеразной цепной реакции. Результаты. Прогрессирование ГЛЖ по результатам повторной ЭхоКГ через 5 лет наблюдалось у 46 человек (29,7%), у 67 пациентов ИММЛЖ оставался в пределах нормативных значений и у 42 - отмечалось его снижение до нормативных величин. В многофакторной регрессионной модели прогнозирования предикторами прогрессирования ГЛЖ в течение 5 лет являлись: носительство мутантного ТТ генотипа гена AGT (ОШ=3,79; 95% ДИ 1,39-10,33; р=0,009), нерегулярное антигипертензивное лечение (ОШ=3,45; 95% ДИ 1,41-8,33; р=0,006), биаллельные сочетания полиморфизма A1166C гена AGTR1 (С аллель) и C(-344)Т) гена CYP11B2 (СТ/ТТ генотипы) (ОШ=1,53; 95% ДИ 1,05-2,23; р=0,028), более высокая степень АГ у носителей ААгенотипа гена AGTR2 (ОШ=1,58; 95% ДИ 1,07-2,33; р=0,022). Точность прогноза прогрессирования ГЛЖ у пациентов с АГ по разработанной многофакторной модели составила 73% при общей безошибочности модели 71%. Заключение. Прогрессирование ГЛЖ в течение 5 лет у пациентов с АГ обусловлено влиянием полиморфизма генов РААС - AGT (М235Т), AGTR1 (A1166C), CYP11B2 (C(-344)T), AGTR2 (С3123А) и их взаимодействиями в сочетании с нерегулярным лечением и степенью заболевания. Purpose. To determine the clinical and genetic risk factors of progression of left ventricular hypertrophy (LVH), taking into account the polymorphism of the genes of the renin-angiotensin- aldosterone system (RAAS), according to the data of a prospective five-year follow-up of patients with essential arterial hypertension (AH). Materials and methods. Clinical and instrumental examination was performed in 155 patients with hypertension, including 82 men and 73 women (average age - 54.5±9.4 years). The signs of LVH were assessed with the help of echocardiography with calculation of the left ventricular myocardial mass index (LVMI). Genotyping of polymorphic loci of the genes of the renin-angiotensin-aldosterone system (RAAS), I/D angiotensin converting enzyme (ACE), М235Т angiotensinogen (AGT), renin G83A (REN), C(-344)T aldosterone BC2 receptors) (CYP1166) II type 1 (AGTR1) and type 2 C3123A (AGTR2) was carried out with polymerase chain reaction. Results. The progression of LVH according to the results of repeated echocardiographic examination in 5 years was observed in 46 patients (29.7%); in 67 patients, LVMI remained within the normative values; in 42 patients, it decreased to the normative values. In the multivariate regression model, the predictors of LVH progression during 5 years were the following: mutant TT genotype of the AGT gene (OR=3.79; 95% CI 1.39-10.33; p=0.009), irregular antihypertensive treatment (OR=3.45; 95% CI 1.41-8.33; p=0.006), biallelic combinations of the polymorphism A1166C of the AGTR1 gene (C allele) and C (-344) T) of the CYP11B2 gene (CT/TT genotypes) (OR=1.53; 95% CI 1.05-2.23; p=0.028), a higher degree of AH in the carriers of the AA genotype of the AGTR2 gene (OR=1.58; 95% CI 1.07- 2.33; p=0.022). The accuracy of prediction of the LVH progression in patients with hypertension according to the multivariate model was 73%, while the infallibility was 71%. Conclusion. The progression of LVH within 5 years in patients with AH is caused by the influence of the polymorphism of the RAAS genes - AGT (M235T), AGTR1 (A1166C), CYP11B2 (C(-344)T), AGTR2 (C3123A) and their interactions in combination with irregular treatment and the degree of the disease.

show abstract

Association of the −344T/C polymorphism in aldosterone synthase gene promoter with left ventricular structure in Chinese Han: A meta-analysis

Cited by 4 publications

References 39 publications

Association of −344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension

Association of −344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension

Associations of excess myocardial mass, echoreflectiveness and aldosterone synthase gene polymorphism in men with hypertension

Прогнозирование Риска Развития Гипертрофии Левого Желудочка При Артериальной Гипертензии С Учетом Полиморфизма Генов Ренин-Ангиотензинальдостероновой Системы

Contact Info

Product

Resources

About