Association of Dopamine Transporter Loss in the Orbitofrontal and Dorsolateral Prefrontal Cortices With Methamphetamine-Related Psychiatric Symptoms

Sekine, Yoshimoto; Minabe, Yoshio; Ouchi, Yasuomi; Takei, Nori; Iyo, Masaomi; Nakamura, Kazuhiko; Suzuki, Katsuaki; Tsukada, Hideo; Okada, Hiroyuki; Yoshikawa, Etsuji; Futatsubashi, Masami; Mori, Norio

doi:10.1176/appi.ajp.160.9.1699

Cited by 222 publications

(170 citation statements)

References 10 publications

Supporting

Mentioning

157

Contrasting

Unclassified

Order By: Relevance

“…Methamphetamine and cocaine abusers show altered function in prefrontal and striatal dopaminergic circuits (Baxter et al, 1988;Chang et al, 2005;Sekine et al, 2003;Volkow et al, 2001a;2001b). Dopaminergic systems in the striatum and prefrontal cortex are also thought to be involved in attention, working memory and impulse control (Arnsten and Li, 2005;Cardinal et al, 2004;Evenden, 1999;Paulus et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Methamphetamine (METH), a compound structurally similar to amphetamine also affects the dopamine system, e.g. it leads to downregulation of striatal D2 dopamine receptors (Chang and Haning, 2006) and dopamine transporters in the striatum (McCann et al, 1998), orbitofrontal cortex, and dorsolateral prefrontal cortex (Sekine et al, 2003). Although cocaine and amphetamines have different pharmacodynamic properties, both substances reduce the availability of D2 receptors, which is thought to alter the individual's ability to perform reward-related behaviors (Volkow et al, 2001a).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impaired time perception and motor timing in stimulant-dependent subjects

Wittmann

Leland

Churan

et al. 2007

Drug and Alcohol Dependence

148

152

View full text Add to dashboard Cite

Stimulant-dependent individuals (SDI) have abnormal brain metabolism and structural changes involving dopaminergic target areas important for the processing of time. These individuals are also more impulsive and impaired in working memory and attention. The current study tested whether SDI show altered temporal processing in relation to impulsivity or impaired prefrontal cortex functioning. We employed a series of timing tasks aimed to examine time processing from the milliseconds to multiple seconds range and assessed cognitive function in 15 male SDI and 15 stimulant-naïve individuals. A mediation analysis determined the degree to which impulsivity or executive dysfunctions contributed to group differences in time processing. SDI showed several abnormal time processing characteristics. SDI needed larger time differences for effective duration discrimination, particularly for intervals of around 1 sec. SDI also accelerated finger tapping during a continuation period after a 1 Hz pacing stimulus was removed. In addition, SDI overestimated the duration of a relatively long time interval, an effect which was attributable to higher impulsivity. Taken together, these data show for the first time that SDI exhibit altered time processing in several domains, one which can be explained by increased impulsivity. Altered time processing in SDI could explain why SDI have difficulty delaying gratification.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impaired time perception and motor timing in stimulant-dependent subjects

Wittmann

Leland

Churan

et al. 2007

Drug and Alcohol Dependence

148

152

View full text Add to dashboard Cite

show abstract

“…has also revealed a reduction of the DAT in MA abusers and in baboons after MA injection [63][64][65][66] .…”

Section: [ 11 C] Win 35428mentioning

confidence: 94%

“…In the PET study with [ 18 F] FCT in the cocaine self-administration model with monkeys, the laterality of DAT function was changed even before enough cocaine was consumed to produce significant overall changes in receptor and transporter availability [58] . has also revealed a reduction of the DAT in MA abusers and in baboons after MA injection [63][64][65][66] .Methylphenidate ( d-threo-MP to the DAT, suggesting that it is a useful PET tracer for imaging presynaptic dopaminergic neurons [67] . A PET imaging study using pretreatment with MP showed a marked decrease of [ 11 C] d-threo-MP binding in the human brain [68] .…”

mentioning

confidence: 99%

Brain dopaminergic system changes in drug addiction: a review of positron emission tomography findings

et al. 2014

View full text Add to dashboard Cite

Dopamine (DA) is considered crucial for the rewarding effects of drugs of abuse, but its role in addiction remains unclear. Positron emission tomography (PET) is the fi rst technology used for in vivo measurement of components of the dopaminergic system in the human brain. In this article, we review the major fi ndings from PET imaging studies on the involvement of DA in drug addiction, including presynaptic DA synthesis, vesicular monoamine transporter 2, the DA transporter, and postsynaptic DA receptors. These results have corroborated the role of DA in addiction and increased the understanding of its underlying mechanisms.Keywords: dopamine; dopaminergic system; drug addiction; positron emission tomography ·Review· Brain Dopaminergic System Dopamine (DA) is a catecholamine neurotransmitter in the nervous system. It has many functions in the brain, including punishment, reward, voluntary movement, mood, attention, motivation, sleep, working memory, and learning [1] .DA is synthesized by the hydroxylation and decarboxylation of L-tyrosine in DA neurons and, before being released into the synapse in response to an action potential, it is stored within presynaptic vesicles (Fig. 1). The action of DA occurs by binding to postsynaptic DA receptors, resulting in the formation of second messengers. There are fi ve subtypes of DA receptors, which can be grouped into two classes or families: D1-like and D-2 like [1,2] . The D1-like receptor family comprises the D1 and D5 receptors, encoded by genes with no introns, acting by way of Gs-proteins and activating adenylyl cyclase, thus increasing cAMP production [3,4] .The D2-like receptor family comprises the D2, D3, and D4 receptors, encoded by genes containing introns. D2-like receptors act via Gi-proteins, inhibit adenylyl cyclase activity, and thus decrease cAMP activity [3,5] .The action of DA in the synapse is terminated primarily by reuptake to the presynaptic membrane through the dopamine transporter (DAT) [6] . Otherwise, DA is partially removed by oxidation by monoamine oxidase orcatechol-O-methyltransferase in the synaptic cleft (Fig. 1).T h e d o p a m i n e r g i c n e u r o n s , w h o s e p r i m a r y neurotransmitter is DA, interconnect many areas of the brain to form a system which originates in the substantia nigra (SN) pars compacta, ventral tegmental area (VTA), and hypothalamus. The dopaminergic system is typically divided into four major pathways: mesocortical (from the VTA to the frontal cortex), mesolimbic (from the VTA to the nucleus accumbens), nigrostriatal (from the SN to the striatum), and tuberoinfundibular (from the hypothalamus to the pituitary gland). The mesostriatal and mesocortical pathways are currently recognized to contribute most to drug addiction [7] . Neurosci Bull October 1, 2014, 30(5): 765-776 766 Drug AddictionThe term addiction is derived from the Latin verb addicere, which referred to the Roman court action of binding a person to another. From the 17th century, addiction has been used to refer to psychoactive substances (...

show abstract

“…In view of research which has demonstrated ecstasy-related degradation in regions of the PFC (Sekine et al 2003) and hippocampus (Thompson et al 2004), and research showing ecstasy-related impairment within the working memory system Montgomery et al 2005b;Wareing et al 2004), it is not surprising that ecstasy users have poorer memory for associative information relative to nonusers (Croft et al 2001b;Gouzoulis-Mayfrank et al 2003;Montgomery et al 2005a). Using a paired associated learning (PAL) task, Croft et al (2001b) asked a sample of ecstasy and cannabis users, cannabis only users and drug naive counterparts to learn associations between six spatially defined stimulus pairs ("spatial") or six colour pairings ("non-spatial").…”

mentioning

confidence: 99%

Effects of ecstasy/polydrug use on memory for associative information

et al. 2012

View full text Add to dashboard Cite

Rationale. Associative learning underpins behaviours that are fundamental to the everyday functioning of the individual. Evidence pointing to learning deficits in recreational drug users merits further examination. Objectives. A word pair learning task was administered to examine associative learning processes in ecstasy/polydrug users. Methods. Conclusions. Overall, the results suggest that long-term ecstasy exposure may induce a deficit in associative learning and this may be in part a consequence of users adopting a more liberal decision criterion value.

show abstract

Association of Dopamine Transporter Loss in the Orbitofrontal and Dorsolateral Prefrontal Cortices With Methamphetamine-Related Psychiatric Symptoms

Cited by 222 publications

References 10 publications

Impaired time perception and motor timing in stimulant-dependent subjects

Impaired time perception and motor timing in stimulant-dependent subjects

Brain dopaminergic system changes in drug addiction: a review of positron emission tomography findings

Effects of ecstasy/polydrug use on memory for associative information

Contact Info

Product

Resources

About