Association of dopamine receptor polymorphisms with schizophrenia and antipsychotic response in a South Indian population

Vijayan, Neetha N; Bhaskaran, Sujatha; Koshy, Linda; Natarajan, Chandrasekhar; Srinivas, Lekshmy; Nair, Chandrasekharan M.; Allencherry, Priya M; Banerjee, Moinak

doi:10.1186/1744-9081-3-34

Cited by 47 publications

(37 citation statements)

References 52 publications

(49 reference statements)

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“…A more recent study of a Caucasian population from the north of Spain reported a lower frequency of the A1 allele in schizophrenic patients than in controls (Parsons et al 2007). The A2 homozygous genotype also appeared to be overrepresented in schizophrenic patients from South India (Vijayan et al 2007). In summary, the A2 allele of TaqIA appears to be predominant in different samples of patients with schizophrenia.…”

Section: Schizophreniamentioning

confidence: 93%

The ANKK1 Kinase Gene and Psychiatric Disorders

et al. 2009

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The TaqIA single nucleotide polymorphism (SNP, rs1800497), which is located in the gene that codes for the putative kinase ANKK1 (ANKK1) near the termination codon of the D2 dopamine receptor gene (DRD2; chromosome 11q22-q23), is the most studied genetic variation in a broad range of psychiatric disorders and personality traits. A large number of individual genetic association studies have found that the TaqIA SNP is linked to alcoholism and antisocial traits. In addition, it has also been related to other conditions such as schizophrenia, eating disorders, and some behavioral childhood disorders. The TaqIA A1 allele is mainly associated with addictions, antisocial disorders, eating disorders, and attention-deficit/hyperactivity disorders, while the A2 allele occurs more frequently in schizophrenic and obsessive-compulsive patients. Current data show that the TaqIA polymorphism may be a marker of both DRD2 and ANKK1 genetic variants. ANKK1 would belong to a family of kinases involved in signal transduction. This raises the question of whether signaling players intervene in the pathophysiology of psychiatric disorders. Basic research on the ANKK1 protein and its putative interaction with the D2 dopamine receptor could shed light on this issue.

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Section: Schizophreniamentioning

confidence: 93%

The ANKK1 Kinase Gene and Psychiatric Disorders

et al. 2009

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“…For example, several studies found no association with schizophrenia in an Indian population for several polymorphisms, such as RS12808482, RS11608185, and the Taq1D (Caprini, et al, 2011;, although one earlier study had found a moderate association between the Taq1D genotype and treatment success in schizophrenia (Vijayan, et al, 2007). One study revealed no link for the Taq1D SNP with reward sensitivity in binge eating disorders (Davis, et al, 2008), another found no link with sensation-seeking for any of 40 SNPs in the DRD2 gene (Derringer, et al, 2010), and still another found no link with ADHD symptomatology among ADHD children and their families (Kollins, et al, 2008).…”

Section: Snp Proxy Search For Rs1116313 Snpmentioning

confidence: 99%

Socioeconomic stress by dopamine receptor 2 gene interactions in the development of obesity

Stanton¹

2013

PsycEXTRA Dataset

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Background: Previous research suggests that early life socioeconomic stress and certain genetic polymorphisms may be partly associated with increased adiposity; however, research on both genetic and environmental predictors fail to account for the dramatic increase in obesity over that last several decades. Hypothesis: It was hypothesized that a GxE interaction between DRD2-related SNPs and parental education would predict trunk and total fat mass. This same interaction would also predict total calories from a 24-hour diet recall, which would mediate its effect on trunk and total fat mass. Sample:The current study analyzed genetic and psychosocial data from 697 participants collected for the Family Heart Study, an investigation examining the relationship between psychosocial behaviors and cardiovascular risk factors. Methods: Interactions were assessed between four single nucleotide polymorphisms (SNPs) in the D2 receptor and ANKK1 genes and tertiles of parental education predicting DXA-scan-measured trunk and total body fat mass. A measure of total calories, as assessed by a 24-hour diet recall, was tested as a mediator of this effect. Results: An interaction between mother's education and RS1116313 SNP predicted trunk fat (F(4,191)=2.94, p=0.022) and total body fat (F(4, 191)=3.94, p=0.004). The effects were driven by a reduction in trunk and total fat mass among C/C or T/T homozygotes with a high mother's education, which was not observed among C/T heterozygotes. Father's education was neither an interactive nor a main effect predictor in any models. Interactions predicting total calories were also non-significant, and no support for mediation was found. Post-hoc analyses revealed that leisure activity was also not a mediator. Alternatively, certain dietary components were predicted by the interactions between mother's education and RS1124492 and between mother's education and RS1800498. Conclusions: Trunk and v total body fat composition are predicted by an interaction between mother's education and the RS1116313 SNP. This effect does not appear to be mediated by total calories or leisure activity. Other SNPs associated with the D2 receptor gene interact with mother's education to predict dietary components.vi

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“…Pharmacogenomics: With increasing interest in the role of genetic factors in the treatment response and side effects of medications, studies from India have tried to address the genetic links of tardive dyskinesia, treatment response and severity of psychopathology (Tiwari et al 2005;Vijayan et al 2007;Thomas et al 2008;Gupta et al 2009Gupta et al , 2013. However, the findings are preliminary and inconclusive.…”

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confidence: 98%

“…Tiwari et al (2005) evaluated the role of six single nucleotide polymorphisms (SNP) in tardive dyskinesia and showed that CYP1A2 1545 C > T SNP was associated with tardive dyskinesia and schizophrenia, but the association was rendered insignificant after corrections for multiple comparisons. Vijayan et al (2007) studied various alleles, genotypes, haplotypes and their linkage disequilibrium and observed that H313HTT genotype was associated with schizophrenia and TaqIB1B1 genotype was significantly associated with higher psychopathology scores. Subjects with H313HCC, TaqIA2A2 and Taq1D1D1 had higher mean improvement scores.…”

mentioning

confidence: 99%