The ANKK1 Kinase Gene and Psychiatric Disorders

Ponce, G.; Pérez‐González, Rocío; Aragüés, Marı́a; Palomo, Tomás; Rodríguez‐Jiménez, Roberto; Jiménez‐Arriero, Miguel Ángel; Hoenicka, Janet

doi:10.1007/s12640-009-9046-9

Cited by 78 publications

(69 citation statements)

References 96 publications

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“…Tables 2 and 3 below provide brief overviews of studies reported recently at these sites. Regarding the phenotype of psychopathy, Ponce and colleagues reported on polymorphisms at TaqIA of ANKK1, near DRD2, finding an association between the Aþ genotype and elevated factor I scores on the PCL-R (Ponce et al, 2008(Ponce et al, , 2003(Ponce et al, , 2009). Fowler and colleagues used the PCL-YV in a sample of ADHD affected subjects aged 12-19 years and looked at correlations with MAOA, 5HTTLPR, and COMT (Fowler et al, 2009).…”

Section: Candidate Gene Studiesmentioning

confidence: 99%

Behavioral genetics in antisocial spectrum disorders and psychopathy: A review of the recent literature

Gunter

Vaughn

Philibert

2010

Behavioral Sci & The Law

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Behavioral geneticists are increasingly using the tools of molecular genetics to extend upon discoveries from twin, family, and adoption studies concerning the heritability of antisocial spectrum disorders and psychopathy. While there is a substantial body of research concerning antisocial spectrum disorders in the behavioral genetics literature, only a few studies could be located using the phenotype of psychopathy. In this report we summarize some of the recent molecular genetics work concerning antisocial spectrum disorders and psychopathy, with a focus on genes involved in the serotonergic and dopaminergic pathways, while also mentioning some of the novel genetic factors being considered. Monoamine oxidase (MAOA) and the serotonin transporter (5HTT) are reviewed at length, as these genes have received significant scientific attention in recent years and are sites of high biological plausibility in antisocial spectrum disorders and psychopathy.

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Section: Candidate Gene Studiesmentioning

confidence: 99%

Behavioral genetics in antisocial spectrum disorders and psychopathy: A review of the recent literature

Gunter

Vaughn

Philibert

2010

Behavioral Sci & The Law

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“…For a long time, Taq1A was thought to belong to the DRD2 gene and it was studied that way [8-11]. Taq1A is one of the most studied genetic variations in a wide range of psychiatric disorders and it is also linked to alcoholism and antisocial traits [20]. However, today it is well known that Taq1A belongs to the ANKK1 gene, located in exon 8, adjacent to DRD2 [14].…”

Section: Introductionmentioning

confidence: 99%

Association between Polymorphisms of the DRD2 and ANKK1 Genes and Suicide Attempt: A Preliminary Case-Control Study in a Mexican Population

Genis‐Mendoza¹,

López‐Narváez²,

Tovilla-Zárate³

et al. 2017

Neuropsychobiology

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Background: The aim of this study was to analyze the possible association of polymorphic variants of the DRD2 and ANKK1 genes with suicide attempt in a Mexican population. Methods: We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of DRD2 (rs6275 and rs1799978) and 1 polymorphism of ANKK1 (rs1800497); then we analyzed the association between suicide attempt and these polymorphisms through genotypes, alleles, and inheritance models. Results: Individuals who carried the TT genotype of the rs1800497 showed a 3-fold risk of attempting suicide (OR = 3.01; 95% CI 1.56–5.81, p = 0.001) when evaluated through the recessive model. In an analysis stratified by gender, this risk factor remained present among females (OR = 2.81; 95% CI 1.37–5.75) as well as males (OR = 3.3; 95% CI 1.01–10.77). Conclusion: Our results suggest that the rs1800497 variant of the ANKK1 gene could increase the risk of suicide attempt in a Mexican population. However, further studies using larger samples are necessary to obtain more conclusive results.

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“…Taken together, there are several avenues implicating epigenetic mechanisms in pathological impulsive behavior found in neuropsychiatric disorders that link not only serotonergic and dopaminergic (Ponce et al, 2009) systems, but also MAO-activity and COMT (Hoenicka et al, 2010) genes and even Neuropeptide Y gene (Lesch et al, 2011) in the disease etiopathogenesis. As yet, one may only assume that the relative 'weakness' or 'strength' of the forces inducing epigenetic modulations of future genomes that influence impulsiveness may regulate outcomes of linkage studies.…”

Section: Epigenetic Implications Modulating Impulsiveness: a Case Formentioning

confidence: 99%

Neuroquantum Theories of Psychiatric Genetics: Can Physical Forces Induce Epigenetic Influence on Future Genomes?

Blum

Braverman

Waite³

et al. 2015

Neuroquantology

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This paper serves to encourage quantum physicists to engage in psychiatric based research on the brain and its functions (i.e., consciousness, memory, attention). By using physics theorems such as Einstein's theory of relativity and the string theory, both physicists and geneticists alike may be able to elucidate potential links between components of the universe and their effects on the human brain. We have outlined some interesting posits including the cosmos' role in evolutionary biology, alpha bonding in biological molecules, and environmentally induced epigenetic effects on genetics. We also explore how physical forces can influence human memory, behavioral traits, and rates of addiction. Impulsiveness is used to exemplify how environmental changes can contribute to epigenetics and its hereditary alterations. We propose the idea of the presence of a "mental universe," where brain functionality like consciousness is a continuum of physically altered pathways. The realization that the universe and all of its precepts remains a mystery is reflected in the lack of a standardized "unified" physics theorem and mathematical equation that can explain universal dimensions (physical and mental), and as such, so is the complex nature of the functionality of the human brain. We provide herein a suggestion to remedy possible confusion, whereby we attempt to show the relationship of brain as a complex quantum-like organ and the impact of epigenetics on behavioral expression.

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The ANKK1 Kinase Gene and Psychiatric Disorders

Cited by 78 publications

References 96 publications

Behavioral genetics in antisocial spectrum disorders and psychopathy: A review of the recent literature

Behavioral genetics in antisocial spectrum disorders and psychopathy: A review of the recent literature

Association between Polymorphisms of the DRD2 and ANKK1 Genes and Suicide Attempt: A Preliminary Case-Control Study in a Mexican Population

Neuroquantum Theories of Psychiatric Genetics: Can Physical Forces Induce Epigenetic Influence on Future Genomes?

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