Association of DNA Methylation Patterns in 7 Novel Genes With Ischemic Stroke in the Northern Chinese Population

Xu, Jia; Hu, Bifeng; Liu, Yue; Zhai, Yun; Sun, Yanyan; Sun, Hongwei; Li, Fang; Wang, Jiamin; Feng, Anqi; Tang, Ying; Zhao, Jingbo

doi:10.3389/fgene.2022.844141

Cited by 7 publications

(4 citation statements)

References 37 publications

(47 reference statements)

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“…Meanwhile, Hongwei Sun reported overexpression of CDH2 in MI vascular smooth muscle cells compared with that in controls 28 . Interestingly, the mesenchymal marker CDH2 was downregulated, while the epithelial marker CDH1 was increased during MI, suggesting that EMT‐related signalling rather than the EMT process is associated with AMI 29 …”

Section: Discussionmentioning

confidence: 99%

Identification of important genes related to anoikis in acute myocardial infarction

Song,

Yakufujiang,

Zhou

et al. 2024

J Cellular Molecular Medi

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Acute myocardial infarction (AMI) increasingly precipitates severe heart failure, with diagnoses now extending to progressively younger demographics. The focus of this study was to pinpoint critical genes linked to both AMI and anoikis, thereby unveiling potential novel biomarkers for AMI detection and intervention. Differential analysis was performed to identify significant differences in expression, and gene functionality was explored. Weighted gene coexpression network analysis (WGCNA) was used to construct gene coexpression networks. Immunoinfiltration analysis quantified immune cell abundance. Protein–protein interaction (PPI) analysis identified the proteins that interact with theanoikis. MCODE identified key functional modules. Drug enrichment analysis identified relevant compounds explored in the DsigDB. Through WGCNA, 13 key genes associated with anoikis and differentially expressed genes were identified. GO and KEGG pathway enrichment revealed the regulation of apoptotic signalling pathways and negative regulation of anoikis. PPI network analysis was also conducted, and 10 hub genes, such as IL1B, ZAP70, LCK, FASLG, CD4, LRP1, CDH2, MERTK, APOE and VTN were identified. IL1B were correlated with macrophages, mast cells, neutrophils and Tcells in MI, and the most common predicted medications were roxithromycin, NSC267099 and alsterpaullone. This study identified key genes associated with AMI and anoikis, highlighting their role in immune infiltration, diagnosis and medication prediction. These findings provide valuable insights into potential biomarkers and therapeutic targets for AMI.

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Section: Discussionmentioning

confidence: 99%

Identification of important genes related to anoikis in acute myocardial infarction

Song,

Yakufujiang,

Zhou

et al. 2024

J Cellular Molecular Medi

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“…The sixth hub Pcdhb10 encodes a calcium-dependent cell–cell adhesion protein of the cadherin superfamily. PCDHs have been reported to be relevant to epilepsy and neurodegenerative diseases 51 . Defective function of cadherin, such as PCDH19, is known to be related to febrile convulsions and most often patients are drug-resistant to treatment 52 .…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic analysis reveals distinct adaptive molecular mechanism in the hippocampal CA3 from rats susceptible or not-susceptible to hyperthermia-induced seizures

Bando

Bertonha

Menezes

et al. 2023

Sci Rep

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Febrile seizures during early childhood are a relevant risk factor for the development of mesial temporal lobe epilepsy. Nevertheless, the molecular mechanism induced by febrile seizures that render the brain susceptible or not-susceptible to epileptogenesis remain poorly understood. Because the temporal investigation of such mechanisms in human patients is impossible, rat models of hyperthermia-induced febrile seizures have been used for that purpose. Here we conducted a temporal analysis of the transcriptomic and microRNA changes in the ventral CA3 of rats that develop (HS group) or not-develop (HNS group) seizures after hyperthermic insult on the eleventh postnatal day. The selected time intervals corresponded to acute, latent, and chronic phases of the disease. We found that the transcriptional differences between the HS and the HNS groups are related to inflammatory pathways, immune response, neurogenesis, and dendritogenesis in the latent and chronic phases. Additionally, the HNS group expressed a greater number of miRNAs (some abundantly expressed) as compared to the HS group. These results indicate that HNS rats were able to modulate their inflammatory response after insult, thus presenting better tissue repair and re-adaptation. Potential therapeutic targets, including genes, miRNAs and signaling pathways involved in epileptogenesis were identified.

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“…Among the identified significant CpG sites differentially associated with changes in both FPG and HbA1c (RYGB vs. IMI), 4 CpG sites including cg18373318 ( SNX18 ), cg26878734 ( LNPK ), cg05994094 ( CCDC178 ) and cg08383526 ( ADAM7 ) showed robust significance after genomic correction. Interestingly, methylation at cg18373318 ( SNX18 ) has been previously shown to be associated with ischemic stroke by a previous EWAS [ 24 ]; ischemic stroke is one of the multiple cardiovascular outcomes observed in individuals with obesity [ 25 ]. The SNX18 gene encodes a member of the sorting nexin family, which are involved in endocytosis and intracellular vesicle trafficking [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

DNA methylation is differentially associated with glycemic outcomes by different types of weight-loss interventions: an epigenome-wide association study

et al. 2023

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Background Alterations in DNA methylation (DNAm) have been reported to be a mechanism by which bariatric surgeries resulted in considerable metabolic improvements. Previous studies have mostly focused on change in DNAm following weight-loss interventions, yet whether DNAm prior to intervention can explain the variability in glycemic outcomes has not been investigated. Here, we aim to examine whether baseline DNAm is differentially associated with glycemic outcomes induced by different types of weight-loss interventions. Methods Participants were 75 adults with severe obesity who underwent non-surgical intensive medical intervention (IMI), adjustable gastric band (BAND) or Roux-en-Y gastric bypass (RYGB) (n = 25 each). Changes in fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) were measured at 1-year after intervention. DNAm was quantified by Illumina 450 K arrays in baseline peripheral blood DNA. Epigenome-wide association studies were performed to identify CpG probes that modify the effects of different weight-loss interventions on glycemic outcomes, i.e., changes in FPG and HbA1c, by including an interaction term between types of intervention and DNAm. Models were adjusted for weight loss and baseline clinical factors. Results Baseline DNAm levels at 3216 and 117 CpGs were differentially associated with changes in FPG and HbA1c, respectively, when comparing RYGB versus IMI. Of these, 79 CpGs were significant for both FPG and HbA1c. The identified genes are enriched in adaptive thermogenesis, temperature homeostasis and regulation of cell population proliferation. Additionally, DNAm at 6 CpGs was differentially associated with changes in HbA1c when comparing RYGB versus BAND. Conclusions Baseline DNAm is differentially associated with glycemic outcomes in response to different types of weight-loss interventions, independent of weight loss and other clinical factors. Such findings provided initial evidence that baseline DNAm levels may serve as potential biomarkers predictive of differential glycemic outcomes in response to different types of weight-loss interventions.

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Association of DNA Methylation Patterns in 7 Novel Genes With Ischemic Stroke in the Northern Chinese Population

Cited by 7 publications

References 37 publications

Identification of important genes related to anoikis in acute myocardial infarction

Identification of important genes related to anoikis in acute myocardial infarction

Transcriptomic analysis reveals distinct adaptive molecular mechanism in the hippocampal CA3 from rats susceptible or not-susceptible to hyperthermia-induced seizures

DNA methylation is differentially associated with glycemic outcomes by different types of weight-loss interventions: an epigenome-wide association study

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