Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer’s Disease. The Alzheimer’s Disease DREAM Challenge was designed as a computational crowdsourced project to benchmark the current state-of-the-art in predicting cognitive outcomes in Alzheimer’s Disease based on high-dimensional, publicly available genetic and structural imaging data. This meta-analysis failed to identify a meaningful predictor developed from either data modality, suggesting that alternate approaches should be considered for to prediction of cognitive performance.
Superbasic sites have been generated on the mesoporous silica materials for the first time, through a
new strategy to prepare the MgO-modified SBA-15 in one-pot synthesis and then to disperse KNO3,
possessing the good textural structure of the host and the high basic strength (H
-) of 27.0. The in situ
coated Mg species passivated the silanol groups on the surface of siliceous SBA-15 so that the
mesostructure of SBA-15 could be reserved after the composite was loaded with KNO3 and activated at
high temperature. Existence of the special protection layer of MgO on the surface of SBA-15 was also
beneficial for decomposition of KNO3 to form superbasic sites on the mesoporous silica. The influence
of coating amount of MgO on the protection of the textural properties of SBA-15 is examined and discussed
in terms of consuming surface silanol groups. Dispersion and decomposition of KNO3 on the MgO layer
is also explored. Other metal oxides such as CaO, ZnO, and Al2O3 are in situ coated on the surface of
SBA-15 through one-pot synthesis and their function of protecting SBA-15 is evaluated for comparison
with MgO.
Developing earth-abundant, highly active, and durable electrocatalysts for the oxygen evolution reaction (OER) is very important for many renewable energy conversion processes. Herein, we report a novel OER electrocatalyst of NiCo layered double hydroxide@NiCo-hydroxysulfide (NiCo-LDH@HOS) nanosheet arrays, which are prepared by a rapid room-temperature sulfurization of the surface of NiCo-LDH nanosheets grown on Ni foam. The surface sulfurization exerts important influences/changes on the structure, composition, surface properties and chemistry of NiCo-LDH. After surface sulfurization, the resulted NiCohydroxysulfide layer armor improved electrical conductivity and chemical resistance to alkaline electrolyte, delivers a stable current density of 10.0 mA cm −2 at a low overpotential of 293 mV in 0.1 M KOH solution, maintaining high stability during a 62 h test. The achieved enhanced oxygen evolution activity and improved durability are superior to those of NiCo-LDH nanosheets and benchmark commercial RuO 2 . This example of NiCo-LDH@HOS obtained via surface sulfurization with enhanced OER electrocatalysis performance, highlights an important strategy to fabricate high-performance metal hydroxide/hydroxysulfides heterostructured catalysts for OER and other electrochemical storage and conversion progress.
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