Association of dietary inflammatory potential with risk of overall and cause-specific mortality

Li, Xiude; Chen, Bin; Zhang, Jiawei; Li, Meiling; Zhang, Zhuang; Zhu, Yushan; Zeng, Xufen; Li, Hairong; Wang, Yingying; Wang, Sufang; Hu, Anzi; Zhao, Qihong; Yang, Wanshui

doi:10.1017/s0007114521002907

Cited by 8 publications

(13 citation statements)

References 53 publications

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“…In general, diets high in carbohydrates and saturated fats and low in fiber seem to have proinflammatory effects that promote cell proliferation, DNA damage, and immune activation [97], thereby leading to worse cancer outcomes. Within the US National Health and Nutrition Examination Survey (NHANES), a positive association was observed between high vs. low diet inflammation index and overall cancer mortality (n = 490 cancer deaths) [98], further supported by a meta-analysis of six prospective studies on this issue [97]. This association was also strong and consistent for overall cancer mortality in the EPIC study [63], although cancer-specific mortality outcomes have not been examined.…”

Section: Risk Factors For Cancer Mortalitymentioning

confidence: 97%

The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study

et al. 2021

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Evidence on the impact of diet, alcohol, body-mass index (BMI), and physical activity on mortality due to cancer and other cancer-related outcomes is still scarce. Herein, we reviewed the contribution of the European Prospective Investigation into Cancer and Nutrition (EPIC) study to the current state of the art on the role of these factors in cancer mortality. We identified 45 studies using a rapid systematic review methodology. Dietary factors associated with reduced cancer mortality included raw vegetable intake; dietary fiber intake; the Mediterranean diet; other dietary scores; other diet patterns including low meat eaters, vegetarians/vegans, or fish eaters; dietary intake (or biomarkers) of some vitamins (e.g., vitamin D, vitamin K2, or Vitamin C); and intake of lignans. Physical activity and following healthy lifestyle recommendations also reduced cancer mortality risk. In contrast, dietary factors associated with higher cancer mortality risk included poor diet quality, consumption of alcohol and soft drinks including juice, and, to a lesser extent, intake of some fatty acids. Excess weight and obesity also increased the risk of cancer mortality. The EPIC study holds valuable information on diet and lifestyle factors and offers a unique opportunity to identify key diet-related factors for cancer mortality prevention.

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Section: Risk Factors For Cancer Mortalitymentioning

confidence: 97%

The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study

et al. 2021

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“…NHANES is a cross-sectional survey designed to assess the health and nutritional status of the entire US population by enrolling a nationally representative sample of approximately 5000 participants per year. The EDIP and EDIH index have already been developed and validated in the NHANES ( 33 , 34 ).…”

Section: Methodsmentioning

confidence: 99%

Dietary inflammatory and insulinemic potential, risk of hepatocellular carcinoma, and chronic liver disease mortality

Lü

Liu

Petrick

et al. 2023

JNCI Cancer Spectrum

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Background Diet modulates inflammation and insulin response and may be an important modifiable factor in the primary prevention of hepatocellular carcinoma (HCC) and chronic liver disease (CLD). We developed the empirical dietary inflammatory pattern (EDIP) and empirical dietary index for hyperinsulinemia (EDIH) scores to assess the inflammatory and insulinemic potentials of diet. Objective We prospectively examined the associations of EDIP and EDIH at baseline with the following HCC risk and CLD mortality. Design We followed 485,931 individuals in the NIH–AARP Diet and Health Study since 1995. Cox proportional hazards regression was used to calculate multivariable hazard ratios (HRs) and 95% confidence intervals (95%CIs). Results We confirmed 635 incident HCC cases and 993 CLD deaths. Participants in the highest compared to those in the lowest EDIP quartile had 1.35 times higher risk of developing HCC (95% CI: 1.08-1.70, Ptrend =0.0005), and had 1.70 times higher CLD mortality (95% CI: 1.41-2.04, Ptrend <0.0001). For the same comparison, participants with highest EDIH were at increased risk of HCC (HR = 1.53, 95% CI: 1.20-1.95, Ptrend =0.0004), and CLD mortality (HR = 1.72, 95% CI: 1.42-2.01, Ptrend <0.0001). Similar positive associations of scores with HCC risk and CLD mortality were observed for both women and men. Moreover, individuals in both highest EDIP and EDIH tertiles had 92% increased HCC risk (95% CI: 1.43-2.58) and had 98% increased CLD mortality (95% CI: 1.27-3.08), compared with those in both lowest tertiles. Conclusions Our findings suggest that inflammation and hyperinsulinemia are potential mechanisms linking diet to HCC development and CLD mortality.

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“…The state of the evidence with regards to RRR-derived DPs and non-communicable diseases such as CVD and diabetes is gradually growing. A literature search on PubMed and Embase up to May 2022 returned seventeen studies using data from longitudinal cohorts looking at prospective associations between RRR-derived DPs with CVD risk and/or all-cause mortality (11,(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) , and nineteen studies investigating associations with the risk of developing diabetes (12,(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49) . The vast majority of these studies have been published since 2015, and have included samples from a variety of populations including the USA (n 8 (20,24,25,31,39,40,42,45,46) ); Europe (n 11 (16,<...…”

Section: Dietary Patterns Emerging From Longitudinal Cohort Studiesmentioning

confidence: 99%

Dietary patterns derived by reduced rank regression and non-communicable disease risk

2022

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Most current nutrition policies and dietary recommendations still reflect decades of research addressing the mechanism of action or health risks of individual nutrients. Yet, most high-income countries including the UK are far from reaching the dietary intakes which are recommended for good health. Food-based dietary patterns (DPs) can help target specific combinations of foods that are associated with disease risk, recognising the coexistence of multiple nutrients within foods and their potential synergistic effects. Reduced rank regression (RRR) has emerged as a useful exploratory approach which uses a priori knowledge of the pathway from diet to disease to help identify DPs which are associated with disease risk in a particular population. Here we reviewed the literature with a focus on longitudinal cohort studies using RRR to derive DPs and reporting associations with non-communicable disease risk. We also illustrated the application of the RRR approach using data from the UK Biobank study, where we derived DPs that explained high variability in a set of nutrient response variables. The main DP was characterised by high intakes of chocolate and confectionery, butter and low-fibre bread, and low intakes of fresh fruit and vegetables and showed particularly strong associations with CVD, type 2 diabetes and all-cause mortality, which is consistent with previous studies that derived ‘Western’ or unhealthy DPs. These recent studies conducted in the UK Biobank population together with evidence from previous cohort studies contribute to the emerging evidence base to underpin food-based dietary advice for non-communicable disease prevention.

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Association of dietary inflammatory potential with risk of overall and cause-specific mortality

Cited by 8 publications

References 53 publications

The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study

The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study

Dietary inflammatory and insulinemic potential, risk of hepatocellular carcinoma, and chronic liver disease mortality

Dietary patterns derived by reduced rank regression and non-communicable disease risk

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