Association of diamine oxidase and histamine N-methyltransferase polymorphisms with presence of migraine in a group of Mexican mothers of children with allergies

Meza‐Velázquez, Rocío; López-Márquez, Francisco Carlos; Espinosa-Padilla, S; Rivera-Guillén, Mario Alberto; Ávila-Hernández, J.; Rosales-González, Manuel

doi:10.1016/j.nrleng.2016.02.012

Cited by 14 publications

(15 citation statements)

References 41 publications

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“…They focused on the possible association between 2 functional single‐nucleotide polymorphisms (SNPs) in DAO with the severity of allergic rhinitis and the number of allergic diseases. Patients possessing the mutant allele developed more allergic diseases and were at higher risk for severe rhinitis despite low IgE levels . Also Khalifa et al .…”

Section: Discussionmentioning

confidence: 98%

Diamine oxidase enzyme: a novel biomarker in respiratory allergy

Refaat

Abdel-Rehim

Elmahdi

et al. 2019

Int Forum Allergy Rhinol

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Background: Well-known allergy tests are used to evaluate and diagnose allergic diseases. The aim of this study was to assess the role of serum level diamine oxidase (DAO) enzyme as a diagnostic marker in respiratory allergy.Methods: This case-control study included 40 patients with respiratory allergies (atopic asthma and allergic rhinitis) as well as 40 age-and sex-matched controls. A detailed past medical history of allergy was collected from each participant including family history of allergy. Physical examination, pulmonary function test (PFT) and measurement of serum levels of total immunoglobulin E (IgE) and DAO were performed. Skin-prick test and specific IgE to common aeroallergens were also carried out.Results: DAO levels were higher in patients than controls. There was a positive correlation between severity of disease and DAO. No significant association was found between DAO level and age, type of respiratory allergy, duration of disease, PFT, eosinophilia, and total IgE. DAO had a high negative predictive value (94.7%) and high sensitivity (97.5%). Conclusion: DAO may be helpful in the assessment of severity and in ruling out respiratory allergy. C 2019 ARS-AAOA, LLC.R espiratory allergy is growing significantly. Estimations worldwide reveal that 5% to 12% of the population are asthmatic, whereas 20% have allergic rhinitis, which is the leading cause of decreased individual productivity. One study showed that around 45% of patients had not yet been diagnosed and that respiratory allergies were underdetermined. 1 Accurate screening and early diagnosis are crucial in the management of respiratory allergy.Mast cells are the main contributor of a typical allergic inflammatory reaction. These cells are activated by exposure to allergens, which, in turn, results in the release of many mediators including histamine, leukotrienes, and specific cytokines. 2 Histamine is the main biomarker of the

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Section: Discussionmentioning

confidence: 98%

Diamine oxidase enzyme: a novel biomarker in respiratory allergy

Refaat

Abdel-Rehim

Elmahdi

et al. 2019

Int Forum Allergy Rhinol

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“…70 Polymorphisms in DAO that decrease enzyme activity have also been associated with an increased prevalence and disability of migraine headache. 71,72 Therefore, decreased activity and/or certain polymorphisms of the DAO enzyme may identify persons that are predisposed to develop histamine intolerance and migraine.…”

Section: Biogenic Aminesmentioning

confidence: 99%

Diet and Headache: Part 1

Martin

Vij

2016

Headache

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“… - no association between functional SNPs in the estrogen metabolism genes COMT, CYP1A1 or CYP19A1 and menstrual related migraine. CYP1A1 (rs4646903) rs1048943) CYP19A1 (rs700519) Meza-Velázquez, R., et al (2017) [49] Case-control study 162 mothers with allergic children (80 with migraine) C314T HNMT - increased frequency of C2029G DAO SNP in disease women than in controls; - both mutated alleles were associated with migraine-related disability; - haplotypes containing both mutated alleles showed a strong association with migraine. - possible synergistic association between HNMT and DAO functional SNPs and migraine.…”

Section: Methodsmentioning

confidence: 99%