Association of depression and its relation with complications in newly diagnosed type 2 diabetes

Bajaj, Sarita; Agarwal, Shalabh Kumar; Varma, Anurag; Singh, Vineet Kumar

doi:10.4103/2230-8210.100670

Cited by 40 publications

(37 citation statements)

References 11 publications

(14 reference statements)

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“…Though body weight is a stronger predictor of depression than diabetes [33], evidence shows that diabetes, independent of weight status, is linked with higher rates of depression [33, 34]; some studies report a four-fold risk increase in diabetic patients [35] that increases with symptom severity [34, 36, 37]. Interestingly, a recent study indicates that obesity may only be linked to depression in individuals with a higher socioeconomic status, and depressive symptoms were associated with increased BMI only in Hispanic women [38].…”

Section: Metabolic Syndrome and Mental Health Comorbiditymentioning

confidence: 99%

Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders

2013

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The increased prevalence and high comorbidity of metabolic syndrome (MetS) and mental health disorders (MHDs) have prompted investigation into the potential contributing mechanisms. There is a bidirectional association between MetS and MHDs including schizophrenia, bipolar disorder, depression, anxiety, attention-deficit/hyperactivity disorder, and autism spectrum disorders. Medication side effects and social repercussions are contributing environmental factors, but there are a number of shared underlying neurological and physiological mechanisms that explain the high comorbidity between these two disorders. Inflammation is a state shared by both disorders, and it contributes to disruptions of neuroregulatory systems (including the serotonergic, dopaminergic, and neuropeptide Y systems) as well as dysregulation of the hypothalamic-pituitary-adrenal axis. MetS in pregnant women also exposes the developing fetal brain to inflammatory factors that predispose the offspring to MetS and psychopathologies. Due to the shared nature of these conditions, treatment should address aspects of both mental health and metabolic disorders. Additionally, interventions that can interrupt the transfer of increased risk of the disorders to the next generation need to be developed.

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Section: Metabolic Syndrome and Mental Health Comorbiditymentioning

confidence: 99%

Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders

2013

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“…Huang and Lin et al 36 showed that statins use in diabetic patients with preexisting hyperlipidemia could decrease the risk of anxiety/depression, especially for patients older than 65 years and for female patients. Bajaj and Agarwal et al 37 did not find this kind of association as dyslipidemia enable toincrease the risk of macrovascular and microvascular complications. There is a pathogenic pathway between diabetes and depression-like microvascular and microvascular complications, disability and comorbidities, perceived disease burden, diabetes length and treatment, smoking and persistent poor glycemic control 38 .Around 67.2% of the depressed diabetic patients in this study had moderate to severe depression(BDI score ≥ 20) raising a deep concern to the health care providers and its impacts on therapeutic compliance .…”

Section: Prevalence Of Depression Among a Sample Of Patients Withmentioning

confidence: 92%

Prevalence of Depression Among a Sample of Patients With Type Ii Diabetesmellitus

Ali¹,

Sulaiman

Sanaan

2018

DMJ

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Background: Diabetes is one of the largest global health emergencies of the 21st century and depression is commonly found as a co morbid condition in chronic medical illnesses. with diabetes are twice as likely to suffer from depression compared to the general population. The predictors of depression in a sample of Iraqi Patients with type 2 Diabetes were examined and evaluated in the present study. Subject and Methods: In the current cross 2 diabetes were invited from three diabetes June 2017 and February 2018. The presence of depression was measured by Beck Depression Inventory (BDI-II) scale. Results: The agerange of the patients was (33 years The study sample comprised a total of 254 patients with equal number of both genders and had disease forth last 9.96 years. The mean BMI was 27.4. More than 72.4% of the patients had uncontrolled blood glucose. The most prevalent co morbidity in patients hypertension (54.3%), dyslipidemia (61%), overweight and obesity(75.2%). A small percentage of the patients was on insulin (22.8%) and smoker (12.2%). The prevalence of clinical depression (BDI >16 scores study showed that aging,female gender, and having dyslipidemia as predictors of depression in the study sample. Conclusions: The study showed that more than two thirds depression, most of them having mild to moderate level. Being older, female gender, and having dyslipidemia were shown to be predictors of depression in type 2 diabetic patients.

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“…Similar findings were observed in a study done by Bajaj et al in Uttar Pradesh. 28 About 43.5% of the study participants experienced somewhat difficulty in carrying out daily activities as per the PHQ-9 questionnaire. This could have led to poor compliance to medication which could have led to poor outcome of the disease.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of depression in patients with type 2 diabetes mellitus and its association with fasting blood sugar levels, in an urban area of Kancheepuram district, Tamil Nadu

Gopalakrishnan

Umadevi

2017

Int J Community Med Public Health

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INTRODUCTIONDiabetes mellitus is a group of metabolic disorders characterized by chronic hyperglycemia associated with disturbances of carbohydrate, fat and protein metabolism due to absolute or relative deficiency in insulin secretion and/or action.1 It is categorized into type 1 and type 2 diabetes mellitus. Type 1 Diabetes mellitus usually manifests before adulthood and accounts for about 5% of the cases. It arises through the autoimmune destruction of pancreatic beta cells, which leaves the patient with severe insulinopenia and extreme hyperglycemia. Type 2 diabetes mellitus (T2DM usually manifests in later adult life and accounts for about 95% of all cases. It develops mainly through a combination of insulin resistance and defective beta cell function. T2DM if not treated adequately, can lead to micro-vascular complications affecting the retina, renal glomerulus and the peripheral ABSTRACT Background: Type 2 diabetes mellitus (T2DM) and depressive disorders are among the major health problems in our community. Chronic medical conditions, like diabetes are affectively stressful for patients and may influence pathophysiologic mechanisms as well as mood. This can lead to depression and poor prognosis of T2DM. This study was done to assess the prevalence of depression among T2DM patients and its association with glycemic control. Methods: This descriptive cross sectional study was carried out among 300 T2DM patients attending Urban Health Training Center (UHTC), Anakaputhur, which belongs to the urban field practice area of our institution. Fasting Blood Sugar levels (FBS) were assessed retrospectively from their medical records; and they were screened for depression by administering the nine items, "Patient Health Questionnaire -9". Results: Of the 300 T2DM patients, 54% were females. The mean age of the participants was 53±9.7 years. 31% of the study participants had fasting blood sugar (FBS) levels above 125 mg/dl. Depression was present in 39.7% of the individuals, among which, 17.3% had mild depression, 13% had moderate depression, 6.7% had moderately severe depression and 2.7% had severe depression. Depression was found to be significantly associated with increasing fasting blood sugar levels, diabetic complications, female gender and diabetic treatment. Conclusions: This study shows that depression is highly prevalent among T2DM patients and is associated with poor prognosis, as reflected by poor glycemic control (FBS) and the occurrence of diabetic complications. So screening and counselling for depression among T2DM patients have to be carried out for optimum control and treatment of T2DM.

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Association of depression and its relation with complications in newly diagnosed type 2 diabetes

Cited by 40 publications

References 11 publications

Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders

Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders

Prevalence of Depression Among a Sample of Patients With Type Ii Diabetesmellitus

Prevalence of depression in patients with type 2 diabetes mellitus and its association with fasting blood sugar levels, in an urban area of Kancheepuram district, Tamil Nadu

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