Association of Cytokine and Cytokine Receptor Gene Polymorphisms with the Risk of Chronic Hepatitis B

Sodsai, Pimpayao; Surakiatchanukul, Thamolwan; Kupatawintu, Pawinee; Tangkitvanich, P; Hirankarn, Nattiya

doi:10.12932/ap0284.31.4.2013

Cited by 16 publications

(12 citation statements)

References 36 publications

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“…IFN-γ not only is a cytokine produced by Th1 and NK cells but has a critical role in the suppression of HBV replication [ 50 , 51 ]. Studies have shown that chronic HBV patients have a lower level of IFN-γ; so, patients may fail to develop an efficient anti-viral immune response [ 51 , 52 ]. In this study, the serum level of IFN-γ in the co-infected patient group was significantly lower than in the mono-HBV patients and mono- C .…”

Section: Discussionmentioning

confidence: 99%

Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients

Dong

Huang

et al. 2016

PLoS Negl Trop Dis

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BackgroundClonorchis sinensis (C. sinensis) is considered to be an important parasitic zoonosis because it infects approximately 35 million people, while approximately 15 million were distributed in China. Hepatitis B virus (HBV) infection is a major public health issue. Two types of pathogens have the potential to cause human liver disease and eventually hepatocellular carcinoma. Concurrent infection with HBV and C. sinensis is often observed in some areas where C. sinensis is endemic. However, whether C. sinensis could impact HBV infection or vice versa remains unknown.Principal FindingsCo-infection with C. sinensis and HBV develops predominantly in males. Co-infected C. sinensis and HBV patients presented weaker liver function and higher HBV DNA titers. Combination treatment with antiviral and anti-C. sinensis drugs in co-infected patients could contribute to a reduction in viral load and help with liver function recovery. Excretory-secretory products (ESPs) may, in some ways, increase HBV viral replication in vitro. A mixture of ESP and HBV positive sera could induce peripheral blood mononuclear cells (PBMCs) to produce higher level of Th2 cytokines including IL-4, IL-6 and IL-10 compared to HBV alone, it seems that due to presence of ESP, the cytokine production shift towards Th2. C. sinensis/HBV co-infected patients showed higher serum IL-6 and IL-10 levels and lower serum IFN-γ levels.Conclusions/SignificancePatients with concomitant C. sinensis and HBV infection presented weaker liver function and higher HBV DNA copies. In co-infected patients, the efficacy of anti-viral treatment was better in patients who were prescribed with entecavir and praziquantel than entecavir alone. One possible reason for the weaker response to antiviral therapies in co-infected patients was the shift in cytokine production from Th1 to Th2 that may inhibit viral clearance. C. sinensis/HBV co-infection could exacerbate the imbalance of Th1/Th2 cytokine.

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Section: Discussionmentioning

confidence: 99%

Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients

Dong

Huang

et al. 2016

PLoS Negl Trop Dis

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“…According to the inclusion and exclusion criteria, 22 articles were included in this study, including five articles on TLR3 rs3775291 polymorphism and the risk of HBV [10][11][12][13][14] and 17 articles on IL-10 rs1800871 and susceptibility to HBV [16][17][18][19][25][26][27][28][29][30][31][32][33][34][35][36][37]. The detailed literature screening process was shown in Figure 1.…”

Section: Results Of Literature Retrievalmentioning

confidence: 99%

Association of TLR3 (rs3775291) and IL-10 (rs1800871) gene polymorphisms with susceptibility to Hepatitis B infection: A meta-analysis

Zhang

et al. 2020

Epidemiol. Infect.

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TLR3 and IL-10 play a crucial role in antiviral defence. However, there is a controversy between TLR3 rs3775291 and IL-10 rs1800871 polymorphisms and the risk of hepatitis B virus (HBV) infection. The purpose of this study is to explore the relationship between the two single nucleotide mutations and the risk of HBV infection by meta-analysis. Medline, EMBASE, Web of Science, CNKI, China Wanfang database were searched for the case-control studies on the relationship between TLR3 rs3775291 and IL-10 rs1800871 polymorphism and susceptibility to HBV, updated to June 2020. The data were analysed by Stata 15.0 software. A total of 22 articles were included. The results showed that in the analysis of IL10 rs1800871 polymorphism and the risk of HBV infection, the pooled OR was 1.21 (95% CI 1.06-1.37), 1.28 (95% CI 1.04-1.56) and 1.20 (95% CI 1.06-1.37) and 1.40 (95% CI 1.07-1.83) in the allele model (C vs. T), dominant model (CC+CT vs. TT), recessive model (CC vs. CT+TT) and homozygous model (CC vs. TT), respectively. There was no statistical significance in the heterozygote model. A subgroup analysis of the Asian population showed similar results. The analysis of TLR3 rs3775291 polymorphism and the risk of HBV showed that in the allele model (T vs. C), the pooled OR was 1.30 (95% CI 1.05-1.61). Except for the recessive model, no significances were found in other genetic models. In conclusion, TLR3 rs3775291 and IL-10 rs1800871 polymorphisms are associated with the risk of HBV. Allele C and genotype CC at IL10 rs1800871 loci, as well as allele T and genotype TT at TLR rs3775291 loci, may increase susceptibility to Hepatitis B infection.

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“…Consequently, a total of 16 relevant studies, of which 14 were in English and 2 in Chinese, were finally included in the meta-analysis. 9 , 15 – 21 , 24 – 30 , 36 Of the selected studies, 2 contained data on both the -590C/T and -33T/C polymorphisms 9 , 27 and 4 evaluated the association in different types of liver diseases 9 , 15 , 24 , 26 ; therefore, these were treated independently. Thus, 15 studies consisting of 3206 controls and 2441 cases (including 1106 HBV patients, 184 HCV patients, 98 HBV–HCV patients, 248 LC patients, 583 HCC patients, 169 drug-induced liver injury patients, and 53 biliary atresia patients) assessed the association in the -590C/T SNP, 9 , 15 – 21 , 24 – 29 , 36 and 3 studies consisting of 413 controls and 734 cases (including 260 HBV patients, 62 LC patients, 154 HCC patients, and 258 alcoholic liver disease patients) assessed the association in the -33T/C SNP.…”

Section: Resultsmentioning

confidence: 99%

“… 9 , 26 – 29 Moreover, we also found several studies investigating the relationship between the -33T/C SNP and liver diseases in which the results were also inconsistent. 9 , 27 , 30 Thus, we performed a meta-analysis pooling all eligible studies published to date to derive a more precise estimation of the association between the -590C/T SNP and liver diseases. We also explored the potential role that the -33T/C SNP plays in liver diseases by performing the first such meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

Association Between IL-4 Polymorphisms and Risk of Liver Disease

Qin

Zeng

et al. 2015

Medicine

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Interleukin-4 (IL-4) polymorphisms have been reported to influence an individual's susceptibility to liver disease as it is a central anti-inflammatory Th2 cytokine; however, these results remain controversial.A comprehensive meta-analysis of the relevant literature was thus performed to better estimate the relationship between IL-4 polymorphisms and liver disease.Systematic searches of various databases (PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure) for studies published before July 5, 2015 were performed. Odds ratios (ORs) with 95% confidence intervals (CIs) calculated in fixed or random-effects models were used to estimate the strength of the association. Subgroup analyses, meta-regression, Galbraith plots, and sensitivity analyses were also performed.A total of 16 case–control studies, of which 15 involved the -590C/T polymorphism and 3 involved the -33T/C polymorphism, were included in the study. With respect to the -590C/T polymorphism, a significantly increased risk of liver diseases was found in the overall population (TT + CT vs CC: OR = 1.25, 95% CI = 1.06–1.49, P = 0.009 and CT vs CC: OR = 1.22, 95% CI = 1.00–1.48, P = 0.048) and the Asian population (TT + CT vs CC: OR = 1.28, 95% CI = 1.04–1.57, P = 0.020). Further subgroup analyses also showed significant associations between the -590C > T polymorphism and the risk of hepatitis C infection and hepatocellular carcinoma. However, no association was found between the -33T/C polymorphism and risk of liver diseases in all comparison models.This meta-analysis suggested that the IL-4 -590C > T polymorphism is associated with an increased risk of hepatitis C infection and hepatocellular carcinoma, especially among the Asian population.

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Association of Cytokine and Cytokine Receptor Gene Polymorphisms with the Risk of Chronic Hepatitis B

Abstract: These preliminary results suggest that polymorphisms in some cytokine genes, particularly the Th2 cytokine, influence persistence of HBV infection.

Cited by 16 publications

References 36 publications

Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients

Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients

Association of TLR3 (rs3775291) and IL-10 (rs1800871) gene polymorphisms with susceptibility to Hepatitis B infection: A meta-analysis

Association Between IL-4 Polymorphisms and Risk of Liver Disease

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