Association Between IL-4 Polymorphisms and Risk of Liver Disease

Wu, Zhitong; Qin, Wenzhou; Zeng, Jie; Huang, Chuan; Yu, Lu; Li, Shan

doi:10.1097/md.0000000000001435

Cited by 13 publications

(8 citation statements)

References 48 publications

(82 reference statements)

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“…Thirdly, we did not search for grey literatures. Therefore, despite that funnel plots of pooled analyses were overall symmetrical, potential publication biases still might influence the robustness of our pooled results [21].…”

Section: Discussionmentioning

confidence: 89%

CTLA-4 polymorphisms and predisposition to digestive system malignancies: a meta-analysis of 31 published studies

Wang

Sun

et al. 2020

World J Surg Onc

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Background The results of genetic association studies regarding cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) polymorphisms and digestive system malignancies were controversial. The authors designed this meta-analysis to more precisely estimate relationships between CTLA-4 polymorphisms and digestive system malignancies by pooling the results of related studies. Methods The authors searched PubMed, Embase, Web of Science, and CNKI for eligible studies. Thirty-one eligible studies were pooled analyzed in this meta-analysis. Results The pooled meta-analysis results showed that genetic distributions of rs231775, rs4553808, and rs733618 polymorphisms among patients with digestive system malignancies and controls differed significantly. Moreover, genotypic distribution differences were also observed for rs231775 polymorphism among patients with colorectal cancer/pancreatic cancer and controls, for rs4553808 and rs5742909 polymorphisms among patients with gastric cancer and controls, for rs3087243 polymorphism among patients with liver cancer and controls, and for rs733618 polymorphism among patients with colorectal cancer and controls in pooled meta-analyses. Conclusions This meta-analysis suggested that rs231775 polymorphism was associated with predisposition to colorectal cancer and pancreatic cancer, rs4553808 and rs5742909 polymorphisms were associated with predisposition to gastric cancer, rs3087243 polymorphism was associated with predisposition to liver cancer, and rs733618 polymorphism was associated with predisposition to colorectal cancer.

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Section: Discussionmentioning

confidence: 89%

CTLA-4 polymorphisms and predisposition to digestive system malignancies: a meta-analysis of 31 published studies

Wang

Sun

et al. 2020

World J Surg Onc

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“…Among the ten IL-37 SNPs analyzed in the Saudi population, three SNPs, rs2723176, rs2723186, rs3811047, have been reported to have a genetic predisposition for auto-immune thyroid disease in the Chinese population 28 . Polymorphisms of other anti-inflammatory cytokines such as IL-10 and IL-4 are also reported to be strongly associated with the outcome of HBV infection 43,44 .…”

Section: Discussionmentioning

confidence: 99%

Association between IL-37 gene polymorphisms and risk of HBV-related liver disease in a Saudi Arabian population

Al-Anazi

Matou‐Nasri

Al-Qahtani

et al. 2019

Sci Rep

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Interleukin-37 (IL-37) has recently been recognized as a strong anti-inflammatory cytokine having anti-tumor activity against hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-infected patients. HCC is a typical inflammation-related cancer, and genetic variations within the IL-37 gene may be associated with the risk of HBV infection. Identification of the allelic patterns that genetically have a high disease risk is essential for the development of preventive diagnostics for HBV-mediated liver disease pathogenesis. In this study, we aimed to investigate the association between single nucleotide polymorphisms (SNPs) within the IL-37 gene and disease sequelae associated with HBV infection. We genotyped ten IL-37 SNPs in 1274 patients infected with HBV and 599 healthy controls from a Saudi Arabian population. Among the selected SNPs, two SNPs (rs2723175 and rs2708973) were strongly associated with HBV infection, and six SNPs (rs2723176, rs2723175, rs2723186, rs364030, rs28947200, rs4392270) were associated with HBV clearance, comparing healthy controls and HBV infected-patients respectively. A suggestive association of rs4849133 was identified with active HBV surface antigen (HBsAg) carrier and HBV-related liver disease progression. In conclusion, our findings suggest that variations at the IL-37 gene may be useful as genetic predictive risk factors for HBV infection and HBV-mediated liver disease progression in the Saudi Arabian population.

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“…For example, IL-4 could signal through IL-4Rα to trigger specialized macrophage activation, promoting the mitigation of helminthic infection and tissue repair in the liver and lung (21), or reduce the production of C-reactive protein (CRP) by human primary hepatocytes (22). Furthermore, IL-4 polymorphism has also been associated with an increased risk of liver disease (23) and severe respiratory syncytial virus (RSV) infection (24). All things considered, it is reasonable to postulate that an increase of IL-4 levels may play an important role in the convalescence of COVID-19 through either T cells, B cells, or other type 2 immunity-associated cells, such as macrophages.…”

Section: Discussionmentioning

confidence: 99%

Elevation of Serum Cytokine Profiles and Liver Metabolomic Normalization in Early Convalescence of COVID-19 Patients

Lou

Deng

et al. 2021

Front. Med.

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Coronavirus disease 2019 (COVID-19) has become a global public health concern. We aimed to study the cytokine profile during the convalescent phase and its association with liver functions. We performed a retrospective study to investigate the longitudinal dynamic serum cytokine, liver function, and metabolomic profiles, as well as their potential correlations, from the viral replication phase to early convalescence. Our results demonstrated that liver injury was common. Liver injury was significantly associated with higher levels of interleukin (IL)-6 and IL-10 (p < 0.05). However, alanine aminotransferase levels decreased during the first week after hospital discharge (p < 0.01). In parallel, T-cell and B-cell immune response-stimulating cytokine IL-4, but not IL-2, was significantly elevated (p < 0.05). Furthermore, interferon-γ (IFN-γ) and tumor necrosis factor-α (TFN-α) levels increased, in contrast to the decrease in IL-6 and IL-10 levels; liver function returned to normal. The metabolomic analysis supported active recovery during early convalescence of COVID-19 patients that had distinct metabolic profiles associated with the hepatic tricarboxylic acid cycle, amino acid metabolism, and lipid metabolism. In addition, we identified a metabolomic association of IL-4 with liver repair. Our findings suggest that discharged patients continue to recover from the physiological effects of COVID-19, and the association of IL-4, IL-6, and IL-10 levels with metabolic changes and liver function repair may have important implications for clinical manifestations and treatment of COVID-19.

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Association Between IL-4 Polymorphisms and Risk of Liver Disease

Cited by 13 publications

References 48 publications

CTLA-4 polymorphisms and predisposition to digestive system malignancies: a meta-analysis of 31 published studies

CTLA-4 polymorphisms and predisposition to digestive system malignancies: a meta-analysis of 31 published studies

Association between IL-37 gene polymorphisms and risk of HBV-related liver disease in a Saudi Arabian population

Elevation of Serum Cytokine Profiles and Liver Metabolomic Normalization in Early Convalescence of COVID-19 Patients

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