Association of cystic fibrosis transmembrane-conductance regulator gene mutation with negative outcome of intracytoplasmic sperm injection pregnancy in cases of congenital bilateral absence of vas deferens

Female cystic fibrosis mutation carriers and assisted reproductive technology: does carrier status affect reproductive outcomes?

“…Twenty-five percent of men with CBAVD only have one CFTR mutation, and there is an increased CFTR mutation frequency in groups of men with non-CBAVD infertility such as those with nonobstructive azoospermia, oligospermia, and asthenospermia (16,17,32,33). Most recently, a study by Lu et al in 2014 demonstrated an increase in the frequency of miscarriages/still births and prevalence of CBAVD in male CF carriers (34). Furthermore, research suggests that the CFTR protein plays a critical role in spermatogenesis.…”

Do assisted reproduction outcomes differ according to aetiology of obstructive azoospermia?

“…According to Buffat et al () and Pasqualotto et al (), ICSI outcomes are poorer in groups of patients with obstruction of inflammatory or infectious aetiology. Recently, Lu et al () detected higher live birth rates in vasectomy group (41.4% vs. 35%, p = .019) and higher miscarriage rates in CBAVD group (11.9% vs. 6.1%, p < .001) opposite results compared to previous Yamamoto's study (Yamamoto et al, ). In contrast, Esteves et al () and Kamal et al () failed to detect differences in fertilisation, pregnancy or live birth rates.…”

“…Condition and outcomes of FIV/ICSI in patients suffering from OA have been investigated in previous studies, albeit with conflicting and disputable results (Buffat et al, ; Esteves et al, ; Kamal et al, ; Lu et al, ; Nicopoullos, Gilling‐Smith, & Ramsay, ; Pasqualotto, Rossi‐Ferragut, Rocha, Iaconelli, & Borges, ).…”

Absence bilatérale des canaux déférents : du diagnostic à l’assistance médicale à la procréation. Expérience de 3 centres

“…Ré cemment, Lu et al ont publié une é tude é valuant les ré sultats en AMP de patients pré sentant une azoospermie obstructive (AO) en diffé renciant deux causes ABCD et non ABCD [30]. Ils relatent pour le premier groupe un taux de grossesse é volutive par transfert d'embryons de 35 % (n = 531) alors que nos ré sultats sont pré senté s en grossesse é volutive par ponction d'ovocytes.…”