Absence bilatérale des canaux déférents : du diagnostic à l’assistance médicale à la procréation. Expérience de 3 centres

Beauvillard, Damien; Perrin, A.; Drapier, Hortense; Ravel, Célia; Fréour, Thomas; Férec, Claude; Braekeleer, Marc De; Amice, V.

doi:10.1016/j.gyobfe.2015.03.009

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Low sperm motility has been observed in CF males in mice and human. 24 It is known that the CFTR protein influences lipid metabolism, but its regulation in spermatogenic cells and underlying mechanisms are currently poorly understood. 25 In human and bovine spermatozoa, the highest concentrations of polyunsaturated fatty acids (PUFA), particularly docosahexaenoic acid (DHA), have been found in the head and tail.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive semen examination in patients with pancreatic-sufficient and pancreatic-insufficient cystic fibrosis

Shtaut

Брагина

et al. 2023

Asian Journal of Andrology

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We examined a cohort of 93 cystic fibrosis (CF) male patients who were pancreatic-sufficient (PS-CF; n=40) or pancreatic-insufficient (PI-CF; n = 53). Complex semen examination was performed, including standard semen analysis, quantitative karyological analysis (QKA) of immature germ cells (IGCs), transmission electronic microscopy (TEM), biochemical analysis, and sperm DNA fragmentation by terminal deoxynucleotidyl transferase-mediated dUTP nickend labeling (TUNEL) assay. Azoospermia was diagnosed in 83 (89.2%) patients. The other 10 (10.8%) patients were found to be nonazoospermic and showed various spermatological diagnoses (asthenozoospermia, n = 2; asthenoteratozoospermia, n = 3; oligoasthenozoospermia, n = 1; oligoasthenoteratozoospermia, n = 3; and normozoospermia, n = 1) with no specific morphological abnormalities. Oligospermia was detected in 89.2% azoospermic and 30.0% nonazoospermic patients. Low seminal pH (<7.0) was found in 74 (89.2%) of 83 azoospermic patients. Moderate leukocytospermia (2.0 × 106–2.2 × 106 ml−1) was revealed in 2.4% azoospermic and 40.0% nonazoospermic semen samples. The signs of partial meiotic arrest at prophase I were found in 4 of 6 nonazoospermic patients examined by QKA of IGCs. The content of fructose and citrate was low in oligospermic and normal in nonoligospermic semen samples. An increased percentage (>30%) of spermatozoa with noncondensed (“immature”) chromatin was revealed in 2 of 6 nonazoospermic semen samples analyzed by TEM.

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Section: Discussionmentioning

confidence: 99%

Comprehensive semen examination in patients with pancreatic-sufficient and pancreatic-insufficient cystic fibrosis

Shtaut

Брагина

et al. 2023

Asian Journal of Andrology

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Implications of Sperm Source on ICSI Outcome: Assessment of TESE and Other Surgical Sperm Retrieval Methods

Abhyankar

Ohlander

Kathrins

2018

Intracytoplasmic Sperm Injection

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Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility

et al. 2019

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CFTR protein regulates electrolyte and fluid transport in almost all tissues with exocrine function, including male reproductive tract. Mutation of CFTR gene causes cystic fibrosis (CF), which affects the function of several organs, and impairs male fertility. The role of CFTR protein in different compartments of male reproductive tract (testis, epididymis, sperm) as well as an impact of CFTR mutation(s) on male fertility phenotype is discussed in relation with the choice of optimal technique for Assisted Reproductive Techniques (ART) management. RésuméLa protéine CFTR est un canal chlore régulant le transport de fluides et d'électrolytes dans presque tous les tissus ayant une fonction exocrine, y compris les voies génitales masculines.Des mutations du gène codant pour cette protéine sont responsables de la mucoviscidose, maladie génétique la plus fréquente en Europe, et de l'aplasie congénitale des canaux déférents. Le rôle joué par la protéine CFTR dans les différents compartiments de l'appareil génital mâle (testicule, épididyme, gamète) ainsi que l'impact d'une mutation CFTR sur le phénotype de fertilité masculine et sa prise en charge thérapeutique sont discutés dans cette revue.

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Absence bilatérale des canaux déférents : du diagnostic à l’assistance médicale à la procréation. Expérience de 3 centres

Cited by 3 publications

References 28 publications

Comprehensive semen examination in patients with pancreatic-sufficient and pancreatic-insufficient cystic fibrosis

Comprehensive semen examination in patients with pancreatic-sufficient and pancreatic-insufficient cystic fibrosis

Implications of Sperm Source on ICSI Outcome: Assessment of TESE and Other Surgical Sperm Retrieval Methods

Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility

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