Association of CYP1A1 and GSTM1 Polymorphisms With Oral Cancer Susceptibility

Abstract

Our meta-analysis was aimed to evaluate the association of CYP1A1 and glutathione-S-transferase M1 (GSTM1) polymorphisms with oral cancer susceptibility.The related articles were searched in PubMed, Embase, and CNKI databases. Fifty eligible studies were included in our meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the relationship of CYP1A1 (rs4646903 and rs1048943) and GSTM1 polymorphisms with oral cancer risk. A random-effects model or fixed-effects model was employed depending on the heterogeneity.In overall analysis, CYP1A1 rs4646903 polymorphism was associated with the risk of oral cancer (CC vs TT: OR 1.65, 95% CI 1.33–2.05; CC vs TC+TT: OR 1.77, 95% CI 1.48–2.11; C vs T: OR 1.17, 95% CI 1.07–1.28), whereas rs1048943 showed no obvious association with oral cancer susceptibility. Moreover, subgroup analysis by ethnicity demonstrated that rs4646903 and rs1048943 both related with increased risk of oral cancer in Asians. Moreover, the analysis based on source of control suggested that rs4646903 could increase the risk for oral cancer in both population- and hospital-based populations, whereas no remarkable relationship of rs1048943 with oral cancer susceptibility was observed. For GSTM1 gene, null genotype appeared to be a risk factor for oral cancer (null vs present: OR 1.23, 95% CI 1.12–1.34), which was also proved in the subgroup analysis.The results demonstrated that CYP1A1 rs4646903 and null genotype of GSTM1 polymorphisms might serve as risk factors for oral cancer.

Epistasis Test in Meta-Analysis: A Multi-Parameter Markov Chain Monte Carlo Model for Consistency of Evidence

“…We applied ETMA to summary statistics from previous meta-analysis [ 27 , 30 , 35 ] (detailed information is presented in Methods). Table 4 shows the summary results of real data analysis (the detailed calculation process using the etma package is shown in S2 Text ).…”

“…This pathway also involves the GST family. We used the data from a meta-analysis of approximately 50 studies investigating the association between CYP1A1/GSTM1 and oral cancer [ 30 ] and selected the studies describing the genotypes of both GSTM1 and CYP1A1 rs4646903. This filter left 13 studies in our real data analysis (the detailed data are shown in S2 Table ).…”

Association of Glutathione-S-Transferases M1 and T1 Deletional Variants with Development of Oral Squamous Cell Carcinoma: A Study in the South-East of Iran

“…Ethnicity may be important factors in determining susceptibility to oral cancer for M1 and T1 alleles (Zhao et al, 2014;Liu et al, 2015). In a meta-analysis, M1 null genotype was found as risk factor for oral neoplasm in Asian but not Caucasians (Zhao et al, 2014).…”

Familial cancer risk in family members and spouses of patients with early‐onset head and neck cancer

“…[38][39][40][41] Several phenotypes involved in carcinogen metabolism have been linked to HNC risk, though results have not always been in agreement. [42][43][44] As a consequence, extrapolations of results of individual studies to other populations cannot be made without further evaluation.…”