Association of Glutathione-S-Transferases M1 and T1 Deletional Variants with Development of Oral Squamous Cell Carcinoma: A Study in the South-East of Iran

“…[ 44 ] Moreover, several reports showed that GSTT1 gene increased the risk of certain types of cancer. [ 32 – 34 , 45 ] However, there is not a common rule, the disease protection effect of GSTT1 null genotype has also been found. [ 29 , 46 ] GSTT1 is associated with the metabolism of detoxification.…”

Section: Discussionmentioning

confidence: 99%

“…GSTT1 null genotype and GSTM1 null genotype could lead to complete absence of the enzyme, [ 28 ] further increasing the risks of various diseases, such as diabetes, [ 29 ] male infertility, [ 30 ] hypertension, [ 31 ] and some types of cancer. [ 22 – 34 ] To date, many researches have indicated the correlation between SCZ and gene polymorphisms of GSTT1, GSTM1. [ 35 – 38 ] However, the results were inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Glutathione S-transferase gene polymorphisms (GSTT1 and GSTM1) and risk of schizophrenia

Zhang¹,

Yang²,

Liu³

et al. 2020

Medicine

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Schizophrenia (SCZ) is a chronic disability disorder related to oxidative stress. Glutathione S-transferase (GST) is a group enzyme that protects cells and tissues from oxidative stress damage. Among GSTs, GSTT1 and GSTM1 have well defined genetic polymorphisms. The purpose of our research was to explore the correlation between GSTT1 and GSTM1 polymorphism and SCZ risk in Chinese Han population. A total of 650 subjects (386 SCZ patients and 264 healthy individuals) were included in this case–control designed study. The GSTT1 and GSTM1 polymorphisms were analyzed by multiplex polymerase chain reaction (PCR). We explored the relationship between these 2 polymorphisms and the risk of SCZ. We found that the GSTT1 null genotype had a protective effect on the development of SCZ [odds ratio (OR) = 0.601, 95% confidence interval (95% CI) = 0.412–0.986, P = .031]. We also found that the combination of null genotypes of the GSTT1 and GSTM1 genes was made at a lower risk of SCZ (OR = 0.452, 95% CI = 0.238–0.845, P = .028). However, we found no correction between Positive and Negative Syndrome Scale score (PANSS) and GSTM1, GSST1 genotypes in SCZ patients. Our finding revealed that GSTT1 null polymorphisms may be related to the reduced risk of SCZ in Chinese Han population, and this risk was further reduced with the combination of GSTT1 null polymorphisms and GSTM1 null polymorphisms.

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“…Deletion polymorphism in GST genes (non-functional alleles) has been found to be associated with the development of certain types of cancer, such as oral cancer (Saravani et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Association of Metabolic and DNA-repair gene polymorphisms with Longevity: a role forGSTT1, GSTPandXPCgenes

Scarfò

Sciandra

Santovito

2020

Preprint

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Aging and longevity are complex processes controlled at different levels, including genetic level. We evaluated the association of seven drug and DNA-repair gene polymorphisms with longevity in an Italian cohort. A sample of 756 subjects aged 18-98 was genotyped for CYP1A1 exon 7 A>G, GSTT1 null, GSTM1 null, GSTP A>G, XRCC1 exon 6 C>T, XRCC1 exon 9 A> G and XPC exon 15 A>C gene polymorphisms. The association between the analyzed gene polymorphisms and longevity was evaluated by dividing the sample into three age groups: 10-50, 51-85, and 86-98.We observed a significant decrease in the frequency of the GSTT1 null, GSTP G and XPC C alleles in the oldest group with respect to the youngest one and with respect to 51-85 age group. We obtained the same results also subdividing the sample into 1-85 and 86-98 age groups. The general linear model analyses confirmed a significant decreasing trend of the above mentioned alleles with age. We hypothesized that these minor alleles, being important in the sensitivity against the development of different types of cancer, may reflect a reduced life-expectancy in carrier subjects and may explain their significantly lower frequency observed among subjects belonging to oldest age group.

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Association of Glutathione-S-Transferases M1 and T1 Deletional Variants with Development of Oral Squamous Cell Carcinoma: A Study in the South-East of Iran

Cited by 9 publications

References 28 publications

Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis

Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis

Glutathione S-transferase gene polymorphisms (GSTT1 and GSTM1) and risk of schizophrenia

Association of Metabolic and DNA-repair gene polymorphisms with Longevity: a role forGSTT1, GSTPandXPCgenes

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