Association of CYP11B2 polymorphisms with susceptibility to primary aldosteronism: a meta-analysis

Jia, Minyue; Zhang, Hong; Song, Xiaoxiao; Pang, Xiaomin; Ye, Wan-lan; Miao, Wenying; Gu, Wei

doi:10.1507/endocrj.ej12-0455

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…Nevertheless, previous studies on the CYP11B2 T-344C polymorphism have shown a significant 21 , 39 or lack of association with hypertension and other cardiovascular parameters 40 . Moreover, Jia et al suggested that the -344C allele may be associated with a decreased risk of idiopathic hyperaldosteronism 41 . Further studies are warranted to elucidate the role of CYP11B2 C/C in the development of CAD.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan

Chou¹,

Ueng²,

Yang³

et al. 2016

Int. J. Med. Sci.

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The aldosterone synthase gene, cytochrome P450 11B2 (CYP11B2), and mineralocorticoid receptor (MR) genes have been reported to be associated with coronary artery disease (CAD). In this study, we investigated the association of single nucleotide polymorphisms (SNPs) of CYP11B2 (CYP11B2 T-344C) and MR (MR C3514G and MR C4582A) with CAD in Taiwanese. Six hundred and nine unrelated male and female subjects who received elective coronary angiography were recruited from Chung Shan Medical University Hospital. The enrolled subjects were those who had a positive noninvasive test. CYP11B2 T-344C, MR C3514G and MR C4582A were determined by polymerase chain reaction-restriction fragment length polymorphism. We found that women with CYP11B2 C/C had a higher risk of developing CAD. However, there were no significant differences in the genotype distributions of MR C3514G and MR C4582A between the women with and without CAD. In multivariate analysis, CYP11B2 T-344C was most significantly associated with CAD in Taiwanese women. In conclusions, CYP11B2 C/C was more significantly associated with the development of CAD than diabetes mellitus or hypertension. This implies that CYP11B2 C/C plays a more important role than some conventional risk factors in the development of CAD in Taiwanese women.

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Section: Discussionmentioning

confidence: 99%

Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan

Chou¹,

Ueng²,

Yang³

et al. 2016

Int. J. Med. Sci.

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“…Their study suggests that the -344C allele may be associated with a lower risk of developing idiopathic primary aldosteronism. 54 The association between transcription rate of CYP11B2 gene and its own polymorphism T-1651C was studied. Mc-Manus et al found that the transcriptional repressor − APEX1 binds the -1651T allele stronger than the -1651C allele, which results in reduced CYP11B2 expression and consequently lower aldosterone production.…”

Section: Mutations and Polymorphisms In Aldosterone Synthase Genementioning

confidence: 99%

Genetic aspects of primary hyperaldosteronism

Korzynska¹,

Jodkowska²,

Gosławska³

et al. 2018

Adv Clin Exp Med

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Primary hyperaldosteronism (PHA) is the most common form of secondary hypertension of hormonal origin. It affects about 10% of all hypertensive patients. It is connected with increased morbidity and mortality from cardiovascular diseases (CVD) compared to patients with essential hypertension of a similar age. Usually, it is an effect of bilateral adrenal hyperplasia (BAH) or aldosterone-producing adenoma (APA), more rare causes of PHA are: unilateral adrenal hyperplasia, aldosterone-producing adrenocortical carcinoma, ectopic aldosterone-producing tumors and familial hyperaldosteronism. Recent genetic studies have thrown a new light on the pathogenesis of PHA, classifying it as a channelopathy. Several mutations within the ion channels encoding genes have been identified. A possible link between primary hyperaldosteronism and polymorphism of aldosterone synthase gene and ion channel genes is still being investigated. In this manuscript, we focus on genetic aspects of primary hyperaldosteronism, and present an up-to-date compilation of available data with the widened pathogenetic approach.

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“…The enzyme catalyzes the last step in the synthesis of the hormone aldosterone from deoxycorticosterone. Aldosterone, in turn, plays a role in the regulation of blood pressure by maintaining water-salt balance, is activated by potassium and promotes its excretion according to the principle of feedback (Gomes-Sanches et al, 2017;Jia et al, 2013;MdDonough et al, 2017).…”

mentioning

confidence: 99%

Algorithms For Preventive Measures For Disease Prevention And Antioxidant Protection

Purtskhvanidze¹,

Orlovtseva²,

Tefikova³

et al. 2022

European Proceedings of Life Sciences

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The worsening, every year, the ecological situation in the world leads to the effect of various toxicants on a person, the formation of free radicals in his body and the development of diseases, including cancer. With their high chemical activity, free radicals form oxidative stress, which leads to intoxication, damage and cell death. One of the main tools in removing toxins from the body is not only enzymes of the cytochrome P450 family, but also the human antioxidant system. Various gene polymorphisms responsible for protecting the body from toxins can lead not only to a decrease in the production of enzymes that carry out the oxidative biotransformation of toxins, but also to a decrease in the protective function of antioxidant system. For 30 patients suffering from chronic and dangerous diseases, molecular genetic studies were carried out and gene polymorphisms responsible for antioxidant system. The genetic characteristics of the antioxidant status described in the article, a prophylactic doctor should recommend a detoxification program, individual nutrition, taking into account the necessary nutritional supplements.

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Association of CYP11B2 polymorphisms with susceptibility to primary aldosteronism: a meta-analysis

Cited by 6 publications

References 39 publications

Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan

Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan

Genetic aspects of primary hyperaldosteronism

Algorithms For Preventive Measures For Disease Prevention And Antioxidant Protection

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