The worsening, every year, the ecological situation in the world leads to the effect of various toxicants on a person, the formation of free radicals in his body and the development of diseases, including cancer. With their high chemical activity, free radicals form oxidative stress, which leads to intoxication, damage and cell death. One of the main tools in removing toxins from the body is not only enzymes of the cytochrome P450 family, but also the human antioxidant system. Various gene polymorphisms responsible for protecting the body from toxins can lead not only to a decrease in the production of enzymes that carry out the oxidative biotransformation of toxins, but also to a decrease in the protective function of antioxidant system. For 30 patients suffering from chronic and dangerous diseases, molecular genetic studies were carried out and gene polymorphisms responsible for antioxidant system. The genetic characteristics of the antioxidant status described in the article, a prophylactic doctor should recommend a detoxification program, individual nutrition, taking into account the necessary nutritional supplements.
Regeneration of the upper lobe of the caudal fin in juvenile Danio rerio fish after experimental amputation under the toxic effect of potassium dichromate and the addition of fermented milk product "Chigyany ROZ" to granulated fish feed was studied. The obtained results allowed us to establish that the product "Chigyany ROZ" has protective properties and protects the regenerating organ from the effects of the gnotoxicant. Regeneration of the zebrafish fin blade under study in a toxicant solution without adding Chigyany ROZ to the fish feed was suppressed, and on day 9 of the experiment it was approximately 2 times behind regeneration b compared to the control. Luminescent analysis of the regenerating fin blade under a microscope, after staining with acridine orange, he showed that fish fed with addition of the lactic acid product "Chigyany ROZ" in blastem contained more RNA, which apparently contributes to the regeneration of the amputated zebrafish fin blade.
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