Association of Corticosteroids and Factor V, Prothrombin, and MTHFR Gene Mutations With Avascular Osteonecrosis in Renal Allograft Recipients

Celik, Ali; Tekis, D.; Sağlam, Funda; Tunali, Sunay; Kabakci, Neslihan; Özaksoy, Dinç; Manisalı, Metin; Özcan, Mehmet Ali; Meral, Murat; Gülay, Hüseyin; Camsari, Taner

doi:10.1016/j.transproceed.2005.12.062

Cited by 35 publications

(22 citation statements)

References 30 publications

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“…Nevertheless, the relatively small study by Celik et al (9) showed no association (OR=0.88). One possible reason for the insignificant effect of the present study was the limited sample size.…”

Section: Discussionmentioning

confidence: 87%

“…The characteristics of the 7 studies included in the present meta-analysis are provided in Table I ( [8][9][10][11][12][13][14]. We reviewed 57 potentially relevant citations and abstracts obtained after a search of PubMed was conducted (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Another such polymorphism is the prothrombin gene G20210A mutation, which is associated with a 20-50% increase in prothrombin plasma levels (31). In addition to the FVL polymorphism, two studies (9,11) investigated the MTHFR C667T polymorphism and five studies (8)(9)(10)13,14) investigated the prothrombin gene G20210A mutation association with ONFH. However, results of most studies indicated a negative conclusion, which reported that MTHFR C667T polymorphism and prothrombin gene G20210A mutation were not risk factors in ONFH.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that FVL was associated with thrombo embolic diseases such as symptomatic pulmonary embolism, deep vein thrombosis and myocardial infarction (6,7). Several case-control studies have been conducted to examine the association between FVL and ONFH (8)(9)(10)(11)(12)(13)(14). However, some studies have shown inconsistent or even contradictory results.…”

Section: Introductionmentioning

confidence: 99%

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Meta-analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility

et al. 2013

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Abstract. Testing for genetic risk associations betweenFactor V Leiden (FVL) and the osteonecrosis of femoral head (ONFH) is common, however, inconsistent results have been previously obtained. To summarize results on the association of FVL mutation polymorphism with ONFH in various populations and to calculate the overall genetic risk factors, we performed a search of electronic databases including PubMed, Elsevier Science Direct, Chinese National Knowledge Infrastructure and the Chinese Biomedical Database to identify published studies correlating the FVL mutation with ONFH. Statistical analysis was performed using Review Manager (RevMan) version 5.0 and Stata statistical software (version 10). We identified 57 titles and included 7 studies comprising 481 cases and 867 controls in this meta-analysis. The groups were pooled, and a significant association between FVL mutation and increased ONFH was found (OR=4.55, 95% CI, 2.75-7.52, P<0.00001). This meta-analysis demonstrated that FVL plays an important role in non-Asian populations. Large sample studies including different ethnic groups and age-and gender-matched groups, as well as multiple gene polymorphism detection should be considered to clarify the association of FVL mutation polymorphism and ONFH susceptibility in the future.

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Section: Discussionmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Meta-analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility

et al. 2013

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“…ON is believed to be a multifactorial disease that is associated in some cases with both a genetic predilection as well as exposure to certain risk factors. These risk factors include corticosteroid use, alcohol intake, smoking and various chronic diseases (renal disease, hematological disease, inflammatory bowel disease, post-organ transplantation and hypertension) [1,7,11,14,19,20,25,26,41].…”

Section: Introductionmentioning

confidence: 99%

Predictive Role of Cytokine Gene Polymorphisms for the Development of Femoral Head Osteonecrosis

Samara¹,

Kollia

Dailiana³

et al. 2012

Disease Markers

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Introduction: Osteonecrosis (ON) is a multifactorial disease that leads to hip destruction. Lately, much focus has been at femoral head preservation with nonsurgical methods. In this study we examined the polymorphisms of IL-1α, IL-1R, IL-1RA, IL-4Rα, IL-1β, IL-12,γIFN, TGF-β, TNF-a, IL-2, IL-4, IL-6 and IL-10 genes for evaluation of their contribution in ON.Material and methods: DNA was extracted from 112 ON patients and 438 healthy donors. Analysis of the polymorphisms was completed using the PCR-SSP method. Statistical analysis was performed using theχ2test to compare the genotype and allelic frequency distribution.Results: The CT and GA genotypes of the IL-1α(-889) and TNF-a (-238) genes were found higher in the patients (51.8% and 10.8%, respectively) compared to the healthy donors (39.7% and 2.1%, respectively). In TGF-βcodon 25, the G to C polymorphism in the homozygous state was found in 1.8% of the patients and the C allele frequency was 8.9%, whereas the G allele frequency was 91.1%. Also, at the IL-10 (-1082) gene the GG genotype was 16.2% in the controls whereas in the patients was 7.2%.Conclusions: Based on the above, we showed that certain genotypes of the IL-1α, TGF-β, IL-10 and TNF-a genes could be related in the pathogenesis of a complicated disease, such as osteonecrosis. The presence of one of the above mentioned polymorphisms or the simultaneous carriage of more than one may further increase the risk for osteonecrosis, especially in those at high risk, such as patients receiving corticosteroids.

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The efficiency of genetically modified mesenchymal stromal cells combined with a functionally graded scaffold for bone regeneration in corticosteroid‐induced osteonecrosis of the femoral head in rabbits

Tsubosaka

Maruyama

Lui

et al. 2023

J Biomedical Materials Res

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Core decompression (CD) with mesenchymal stromal cells (MSCs) is an effective therapy for early-stage osteonecrosis of the femoral head (ONFH). Preconditioning of MSCs, using inflammatory mediators, is widely used in immunology and various cell therapies. We developed a three-dimensional printed functionally graded scaffold (FGS), made of β-TCP and PCL, for cell delivery at a specific location. The present study examined the efficacy of CD treatments with genetically modified (GM) MSCs over-expressing PDGF-BB (PDGF-MSCs) or GM MSCs co-over-expressing IL-4 and PDGF-BB and preconditioned for three days of exposure to lipopolysaccharide and tumor necrosis factor-alpha (IL-4-PDGF-pMSCs) using the FGS for treating steroidinduced ONFH in rabbits. We compared CD without cell-therapy, with IL-4-PDGF-pMSCs alone, and with FGS loaded with PDGF-MSCs or IL-4-PDGF-pMSCs. For the area inside the CD, the bone volume in the CD alone was higher than in both FGS groups. The IL-4-PDGF-pMSCs alone and FGS + PDGF-MSCs reduced the occurrence of empty lacunae and improved osteoclastogenesis. There was no significant difference in angiogenesis among the four groups. The combined effect of GM MSCs or pMSCs and the FGS was not superior to the effect of each alone. To establish an important adjunctive therapy for CD for early ONFH in the future, it is necessary and essential to develop an FGS that delivers biologics appropriately and provides structural and mechanical support.

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Association of Corticosteroids and Factor V, Prothrombin, and MTHFR Gene Mutations With Avascular Osteonecrosis in Renal Allograft Recipients

Cited by 35 publications

References 30 publications

Meta-analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility

Meta-analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility

Predictive Role of Cytokine Gene Polymorphisms for the Development of Femoral Head Osteonecrosis

The efficiency of genetically modified mesenchymal stromal cells combined with a functionally graded scaffold for bone regeneration in corticosteroid‐induced osteonecrosis of the femoral head in rabbits

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