Meta-analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility

Abstract

Abstract. Testing for genetic risk associations betweenFactor V Leiden (FVL) and the osteonecrosis of femoral head (ONFH) is common, however, inconsistent results have been previously obtained. To summarize results on the association of FVL mutation polymorphism with ONFH in various populations and to calculate the overall genetic risk factors, we performed a search of electronic databases including PubMed, Elsevier Science Direct, Chinese National Knowledge Infrastructure and the Chinese Biomedical Database to identify published studies correlating the FVL mutation with ONFH. Statistical analysis was performed using Review Manager (RevMan) version 5.0 and Stata statistical software (version 10). We identified 57 titles and included 7 studies comprising 481 cases and 867 controls in this meta-analysis. The groups were pooled, and a significant association between FVL mutation and increased ONFH was found (OR=4.55, 95% CI, 2.75-7.52, P<0.00001). This meta-analysis demonstrated that FVL plays an important role in non-Asian populations. Large sample studies including different ethnic groups and age-and gender-matched groups, as well as multiple gene polymorphism detection should be considered to clarify the association of FVL mutation polymorphism and ONFH susceptibility in the future.

Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today?

“…Corticosteroids and alcohol lead to cell apoptosis along with precursor cell suppression 25,26 . In addition, there have been reports of several biomarkers and genes that may play a role in osteonecrosis development (see Appendix) [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] .…”