Association of contact lens-related allergic conjunctivitis with changes in the morphology of meibomian glands

Arita, Reiko; Itoh, K.; Maeda, Shogo; Maeda, Koshi; Tomidokoro, Atsuo; Amano, Shiro

doi:10.1007/s10384-011-0103-6

Cited by 59 publications

(39 citation statements)

References 12 publications

(18 reference statements)

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“…1, case 2). The authors conclude that the allergic reaction, rather than contact lens wear, appears to be responsible for abnormal configuration of meibomian gland in patients with contact lens-related allergic conjunctivitis (Arita et al, 2012). …”

Section: Contact Lens Wearingmentioning

confidence: 99%

Ocular surface inflammation impairs structure and function of meibomian gland

Mizoguchi

Iwanishi

Arita

et al. 2017

Experimental Eye Research

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Dysfunction of the meibomian glands alters secreted meibum quantitatively and qualitatively that can lead to damage to the ocular surface epithelium. In response to an unstable tear film cause by meibomian gland dysfunction, ocular surface epithelium is damaged and expresses inflammatory cytokines leading to secondary ocular inflammation. In turn, inflammatory disorders of the palpebral conjunctiva and lid margin may affect the structure and function of meibomian gland. The disorders include allergic conjunctivitis, long-term usage of contact lenses, dermatological diseases that affect conjunctival homeostasis, Stevens-Johnson’s syndrome or chemical burning of the ocular surface and lid margin.

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Section: Contact Lens Wearingmentioning

confidence: 99%

Ocular surface inflammation impairs structure and function of meibomian gland

Mizoguchi

Iwanishi

Arita

et al. 2017

Experimental Eye Research

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“…The exclusion criteria were: (1) patients who had undergone trabeculectomy with MMC in the lower area ( Fig. 1), (2) patients who had used or were using contact lenses, and (3) patients with severe allergic conjunctivitis, Stevens-Johnson syndrome, or chronic graft-versus-host disease; any of these conditions can cause obstructive meibomian gland disorder [15][16][17][18][19][20]. Long-term use of antiglaucoma eye drops containing benzalkonium chloride (BAC) reportedly causes dry eye symptoms, meibomian gland loss, tear dysfunction, and ocular surface disease (OSD) [21,22].…”

Section: Patientsmentioning

confidence: 99%

“…This chronic irritation can cause subclinical conjunctival inflammation, meibomian gland loss, damage to the ocular surface epithelium, and contact lens-related dry eye [13][14][15][16]. On the basis of these observations, it has been speculated that after trabeculectomy with MMC, chronic irritation of the meibomian glands caused by friction between the conjunctiva and the bleb wall during blinking may cause subclinical inflammation, meibomian gland loss, tear film abnormalities, and damage to the ocular surface epithelium, including bleb wall damage.…”

Section: Introductionmentioning

confidence: 99%

Meibomian gland loss due to trabeculectomy

et al. 2014

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“…These subjects also had a significantly lower TBUT compared to the non-contact lens-wearing controls [21], suggesting that the loss of meibomian glands resulted in a functional deficit. Further, meibomian gland distortion was seen with an increased frequency in contact lens wearers with perennial allergic conjunctivitis, but this distortion was not attributed to contact lens wear [59].…”

Section: Non-contact Infrared Meibography In Contact Lens Wearersmentioning

confidence: 93%

Objective Metrics of Ocular Surface Disease in Contact Lens Wearers: Meibography

Qazi

Hamrah

2015

Curr Ophthalmol Rep

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Dry eye symptoms are very prevalent in contact lens wearers and are most commonly attributed to evaporative dry eye (EDE) due to alterations in the quality of the pre-lens tear film lipids. Meibomian gland dysfunction (MGD), the most common cause of EDE, may result in contact lens-associated dry eye and ultimately to intolerance to contact lens wear. Thus, a thorough assessment of meibomian glands and the eyelid margin prior to and during contact lens wear may ensure continuous contact lens tolerance and the maintenance of a healthy ocular surface. Since meibomian glands are not overtly visible on slit-lamp biomicroscopy, imaging methods such as infrared meibography could play an important role in the evaluation of meibomian gland health. This review discusses the most pertinent advances in infrared meibography and its application to contact lens wearers, with a focus on the utility of quantitative imaging methods in the evaluation of meibomian glands.

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Association of contact lens-related allergic conjunctivitis with changes in the morphology of meibomian glands

Abstract: CLAC is associated with an increase in meibomian gland distortion. Allergic reaction, rather than CL wear, appears to be responsible for the increase in meibomian gland distortion in patients with CLAC.

Cited by 59 publications

References 12 publications

Ocular surface inflammation impairs structure and function of meibomian gland

Ocular surface inflammation impairs structure and function of meibomian gland

Meibomian gland loss due to trabeculectomy

Objective Metrics of Ocular Surface Disease in Contact Lens Wearers: Meibography

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