Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis

Qin, Xue; Peng, Qiliu; Qin, Aiping; Chen, Zhiping; Lin, Lih‐Chang; Deng, Yan; Xie, Li; Xu, Jing; Li, Haiwei; Li, Taijie; Li, Shan; Zhao, Jinmin

doi:10.1186/1746-1596-7-136

Cited by 34 publications

(30 citation statements)

References 62 publications

(47 reference statements)

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“…There are 19 subtypes of breast carcinoma according to World Health Organization (WHO) 2003 classification [22]. Mechanism of developing breast cancer is still unclear but the contribution of mutation in BRCA1 and BRCA2 have been reported to be associated with a dominantly increased risk of disease [9]. Breast cancer susceptibility gene l (BRCA 1) is involved in inhibition of cell growth, cell cycle regulation, gene transcription, DNA damage repair and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…It is the fifth leading cause of death in both sexes combined [8]. Breast cancer is one of the most frequently occurring cancer and cancer related deaths are highly prevalent worldwide, which has become a major public health challenge [9]. After skin cancer, breast cancer is the most common malignancy in women accounting of 16% cancer in women.…”

Section: Introductionmentioning

confidence: 99%

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Clinico- pathological profile of patients with breast diseases

et al. 2013

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BackgroundTo evaluate the spectrum of breast diseases and their association with presenting complains of patients.MethodologyIt was a cross sectional study conducted from 1st January 2010 – 30th December 2012. A total of 254 breast specimens of patients, who were admitted in Civil Hospital Karachi with breast complaints, were included. Specimens were collected either from mastectomy, lumpectomy or needle biopsy from the admitted patients. Informed written consent was taken from all the patients. All patients with primary breast diseases were included. Patients undergoing chemotherapy or with secondary breast disease and slides with insufficient specimen were excluded. All data was entered and analyzed through SPSS 19.ResultThere were 254 breast lesions, histologically diagnosed in 3 year review period. The overall mean age of patients with breast lesion was 25.18, SD ± 11.73 with a wide age range of 12–74 years. Most common cases identified are benign 191(75.3%), followed by inflammatory 30(11.8%) and malignant lesions 30(11.8%). Most patients presenting with the complain of pain have diagnosis of fibroadenoma 24 (63.2%) while patient with complain of lump also have the most common diagnosis of fibroadenoma 147 (72.8%).ConclusionsStudy shows that in Pakistani females, mostly encountered breast lesion was fibroadenoma. Due to lack of awareness breast diseases present lately. Awareness must be created among women to reduce the mortality and morbidity with breast lesions.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1037059088969395.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinico- pathological profile of patients with breast diseases

et al. 2013

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“…It has been hypothesized that women possessing the low activity COMT genotype (AA or Met/Met) might be at greater risk of breast cancer due to higher concentrations of catechol estrogen intermediates [56–58]. Unexpectedly, results from the most recent meta-analysis [59] of 56 studies including 34,358 breast cancer cases and 45,429 controls show no evidence of significant associations between the COMT Val158Met polymorphism and breast cancer risk in any genetic model (comparing recessive and dominant models with each other). Although these findings did not change in subgroup analyses by ethnicity, source of controls, or menopausal status, they must be interpreted with caution because of the large heterogeneity between studies and lack of data for adjustment of other covariates such as age, body mass index (BMI), lifestyle, and environmental factors.…”

Section: Role Of Genetic Variation In Estrogen Metabolismmentioning

confidence: 99%

Estrogen metabolism and breast cancer

2015

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There is currently accumulating evidence that endogenous estrogens play a critical role in the development of breast cancer. Estrogens and their metabolites have been studied in both pre- and postmenopausal women with more consistent results shown in the latter population, in part because of large hormonal variations during the menstrual cycle and far fewer studies having been performed in premenopausal women. In this review we describe in detail estrogen metabolism and associated genetic variations, and provide a critical review of the current literature regarding the role of estrogens and their metabolites in breast cancer risk.

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“…9 After skin cancer, breast cancer is the most common malignancy in women accounting of 16% cancer in women. It has also been present as unknown origin tumour and also one of the first tumours to be ruled out in the presence of tumour of unknown origin in women.…”

Section: Breast Diseasesmentioning

confidence: 99%

A study on clinical profile and management of lump in breast at tertiary rural hospital, Wardha, Maharashtra, India

Chandak

Tabrez

2017

Int Surg J

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Background: Breast lumps diseases are one of the most common diseases in India which include congenital, traumatic, inflammatory, hormonal mastopathy, benign and malignant neoplastic conditions. Around 200,000 cases of breast diseases are diagnosed annually. In India, as there is no study of breast disease conducted separately in rural India hence studies are required to evaluate the incidence and prevalence of breast lump diseases so that interventions can be done to educate and guide people about the risk factors, importance of screening and management strategies.Methods: We have conducted our study on 50 cases of lump in breast with the objective to know their incidence, clinical, pathological and radiological features of various breast swellings and different investigative approach different treatment modalities and their outcome presenting in rural India.Results: The present study of lump in the breast was based on 50 cases admitted in AVBRH, Wardha, Maharashtra, India. During this period maximum patient were of benign breast lump as compared to malignant. All patients were females with age variation from 15 years to 55 years. Majority of patients had lumps varying from 2 months to more than 12 months.Conclusions: Most of the patients from benign lump were managed with excision of lump and all patient of malignant lump underwent mastectomy.

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Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis

Cited by 34 publications

References 62 publications

Clinico- pathological profile of patients with breast diseases

Clinico- pathological profile of patients with breast diseases

Estrogen metabolism and breast cancer

A study on clinical profile and management of lump in breast at tertiary rural hospital, Wardha, Maharashtra, India

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