Association of components of the metabolic syndrome with the appearance of aggregated red blood cells in the peripheral blood. An unfavorable hemorheological finding

Toker, Sharon; Rogowski, Ori; Melamed, Samuel; Shirom, Arie; Shapira, Itzhak; Berliner, Shlomo; Zeltser, David

doi:10.1002/dmrr.502

Cited by 26 publications

(20 citation statements)

References 49 publications

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“…36 (2) Associated cardiovascular risk factors. Our findings complement earlier studies showing increased EA in obesity, diabetes mellitus, sleep apnea, metabolic syndrome and high levels of serum lipids [11][12][13][14][15] -all of these conditions being associated with both CAD and ED. [16][17][18][19] (3) Stunning of blood.…”

Section: Discussionsupporting

confidence: 91%

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Increased erythrocyte aggregation in men with coronary artery disease and erectile dysfunction

et al. 2009

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We studied the association between erythrocyte aggregation (EA) and erectile dysfunction (ED) in men with coronary artery disease (CAD). Men with CAD documented by coronary angiography filled the Sexual Health Inventory for Males questionnaire to detect ED and assess its severity. EA was evaluated by filming slides of blood smear. Low percentage of slide field covered by erythrocytes represented increased EA. Overall, 133 men with CAD, mean ages 62.4 ± 12.2 years, were included: 100 (75.2%) with ED and 33 (24.8%) without ED. EA was increased among men with ED compared with men without ED (percentage of slide field covered by erythrocytes 66.7 ± 14.7 vs 73.1 ± 14.5%; P ¼ 0.03). After adjustment for age, diabetes mellitus, hemoglobin and hematocrit levels, EA was associated with ED severity (r ¼ 0.18; P ¼ 0.038). We conclude that EA is increased in men with CAD and ED. This finding may be relevant to the pathophysiology of ED in men with CAD.

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Section: Discussionsupporting

confidence: 91%

“…10 Inflammation-associated EA is observed in patients with obesity, diabetes mellitus, sleep apnea, metabolic syndrome and hyperlipidemia. [11][12][13][14][15] All of these conditions are also associated with both CAD and ED. [16][17][18][19] Hence, inflammation-associated EA may contribute to ED in patients with CAD.…”

Section: Introductionmentioning

confidence: 99%

Increased erythrocyte aggregation in men with coronary artery disease and erectile dysfunction

et al. 2009

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“…Hemorheological changes are currently investigated as one of the risk factors of pathologies which are associated with metabolic syndrome. Toker et al indicated an association of components of metabolic syndrome with enhanced erythrocyte aggregation [23]. Other authors found elevated blood viscosity, plasma viscosity and erythrocyte aggregation in metabolic syndrome patients compared to control without metabolic syndrome [27].…”

Section: Discussionmentioning

confidence: 99%

Association between hemorheological alteration and clinical diagnosis of metabolic syndrome among patients qualified for bariatric surgery

Wiewióra

Słowińska-Łożyńska

Glück

et al. 2014

Clinical Hemorheology and Microcirculation

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This study presents the association between metabolic syndrome and hemorheological parameters among obese patients qualified for bariatric surgery.We studied 73 morbidly obese patients who were qualified for bariatric surgery. Blood and plasma viscosity measurements were performed using a cone-plate viscometer (Brookfield DV-II). RBC aggregation was measured using the Laser-assisted Optical Rotational Cell Analyser (LORCA). The following parameters for the aggregation process were estimated: aggregation index (AI), amplitude (AMP), aggregation half-time (t 1/2 ), threshold shear rate (␥ thr ), the fast (T fast ) and the slow (T slow ) component. Metabolic syndrome was defined according to the Adult Treatment Panel III and International Diabetes Federation criteria.The obese presented differences in all rheological properties compared to control, regardless of clinical diagnosis of metabolic syndrome, except that whole blood viscosity was higher only in the obese metabolic syndrome group. No differences among the obese with and without metabolic syndrome were observed except in hematocrit. Whole blood viscosity and corrected blood viscosity correlated positively with WHR and BMI. AI, ␥ thr , T slow correlated positively with BMI, WHR, total cholesterol level and low-density lipoproteins. Negative correlation presented t 1/2 with BMI, WHR, fibrinogen, total cholesterol level and low-density lipoproteins. The study showed that morbid obesity is associated with hemorheological disturbances independently of clinical diagnosis of metabolic syndrome.

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“…Erythrocyte deformability and/or aggregation is an important determinant of passage of blood through capillaries. The degree of erythrocyte aggregation is correlated with the IR index HOMA [ 189 , 405 ]. High hematocrit is inversely related to small vessel endothelial‐dependent vasodilatation [ 280 ].…”

Section: Microcirculation and The Metabolic Syndromementioning

confidence: 99%

Microcirculation and the Metabolic Syndrome

et al. 2007

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The present review, to the authors' knowledge, is the first to specifically address the relationships between microcirculation and metabolic syndrome, a cluster of metabolic and cardiovascular modifications highly prevalent in the general population. Its close link to overweight and insulin resistance makes it the main cause of the worldwide burden of type 2 diabetes. However, metabolic syndrome is also observed in many other diseases, particularly, but not exclusively, those where insulin resistance is a main feature. Analysis of the literature reveals that this clinical situation is invariably linked to microvascular disturbances, such as abnormalities in arteriolar reactivity, capillary recruitment, permeability, and hemorheology. A particularly interesting observation is that these defects in small vessel structure and function are seen very early in life or disease. Very importantly, they further suggest that microcirculatory abnormalities may be not only secondary but also causal to the development and/or aggravation of insulin resistance and metabolic syndrome. Mechanisms responsible for these modifications remain largely unknown, but insulin's vascular effects in the microvascular network, detailed in this review, are at least one example of such connections. The existing data point to a clear, at least bidirectional, relationship between microcirculation and metabolic syndrome. Additional studies should determine the level of reciprocal causality.

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Association of components of the metabolic syndrome with the appearance of aggregated red blood cells in the peripheral blood. An unfavorable hemorheological finding

Cited by 26 publications

References 49 publications

Increased erythrocyte aggregation in men with coronary artery disease and erectile dysfunction

Increased erythrocyte aggregation in men with coronary artery disease and erectile dysfunction

Association between hemorheological alteration and clinical diagnosis of metabolic syndrome among patients qualified for bariatric surgery

Microcirculation and the Metabolic Syndrome

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