Increased erythrocyte aggregation in men with coronary artery disease and erectile dysfunction

Justo, Dan; Mashav, Noa; Arbel, Yaron; Kinori, Michael; Steinvil, Arie; Swartzon, Michael; Molat, B; Halkin, Amir; Finkelstein, Ariel; Heruti, Rafi; Banai, Shmuel

doi:10.1038/ijir.2009.6

Cited by 13 publications

(7 citation statements)

References 31 publications

(38 reference statements)

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“…9 Alterations in erythrocyte aggregation have been reported in several clinical conditions including sepsis, [16][17][18] cardiac ischemia and infarction, [19][20][21] and diabetes mellitus. 22 Further research in the area of microvascular erythrocyte aggregation is needed to fully elucidate its impact on blood flow and tissue oxygenation, as the mechanisms involved in erythrocyte aggregation have not been fully defined.…”

Section: Erythrocyte Deformabilitymentioning

confidence: 99%

Basic Concepts of Hemorheology in Microvascular Hemodynamics

Hamlin¹,

Benedik²

2014

Critical Care Nursing Clinics of North America

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Section: Erythrocyte Deformabilitymentioning

confidence: 99%

Basic Concepts of Hemorheology in Microvascular Hemodynamics

Hamlin¹,

Benedik²

2014

Critical Care Nursing Clinics of North America

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“…Acute circulatory problems of various organs have been reported to be characterized by increased RBC aggregation. These conditions include myocardial ischemia and infarction [30,68,78,133], cerebral ischemia and infarction [37,120] and peripheral vascular diseases [73,75]. The enhancement of RBC aggregation is more prominent in cases of infarction compared to ischemia [30] and during the acute phase of the pathophysiological process [119].…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Erythrocyte aggregation: Basic aspects and clinical importance

Başkurt

Meiselman

2013

Clinical Hemorheology and Microcirculation

166

130

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Red blood cells (RBC) aggregate to form two-and three-dimensional structures when suspended in aqueous solutions containing large plasma proteins or polymers; this aggregation is reversible and shear dependent (i.e., dispersed at high shear and reformed at low or stasis). The extent of aggregation is the main determinant of low shear blood viscosity, thus predicting an inverse relationship between aggregation and in vivo blood flow. However, the effects of aggregation on hemodynamic mechanisms (e.g., plasma skimming, Fåhraeus Effect, microvascular hematocrit) may promote rather than impede vascular blood flow. The impact of enhanced RBC aggregation on endothelial function and hemostatic mechanisms adds further complexity, thereby requiring specific attention to the nature, extent and time course of aggregation when considering its overall influence on tissue perfusion. A detailed understanding of aggregation effects is important from a clinical point of view since it may be enhanced during a variety of pathophysiological processes, including infections, circulatory and metabolic disorders, hematological pathologies and several other disease states. Altered RBC aggregation may be an indicator of disease as well as a factor affecting the course of the clinical condition; the prognostic value of RBC aggregation indices has been demonstrated in various diseases. Currently, RBC aggregation is an easily and accurately measurable parameter, and therefore may be expected to have broader clinical usage in the future.

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“…CRP levels have also been found to be inversely related to NO bioavailability and to have direct effects on the vessel wall, which contributes to atherosclerosis [77]. Increased erythrocyte aggregation, which increases blood viscosity and affects the microcirculation, has also been put forth as a link between obesity, ED, and coronary artery disease [78].…”

Section: Obesity and Endothelial Dysfunctionmentioning

confidence: 99%

Obesity and Erectile Dysfunction: Is Androgen Deficiency the Common Link?

Feeley

Traish

2009

The Scientific World JOURNAL

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Obesity is associated with increased risk of erectile dysfunction (ED); however, the underlying causes of ED in obese individuals remain poorly defined. The aim of this review is to discuss the evidence available on the relationship between obesity and ED. A search of published studies in PubMed from 1970 through 2009 was conducted, and relevant articles were evaluated and discussed.Visceral obesity is a public health threat, and is associated with increased risk of diabetes, vascular disease, endothelial dysfunction, and ED. Plasma testosterone levels are reduced in obesity, further contributing to an increased risk of vascular pathology in obesity. The recognition of the relationship between obesity, reduced testosterone levels, and ED has paved the way for new approaches to manage and treat obese, hypogonadal patients with ED. Obesity profoundly and adversely impacts overall health and, in particular, vascular health, by increasing proinflammatory factors, altering endothelial function and the androgen endocrine milieu, thus increasing the risk of ED.

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Increased erythrocyte aggregation in men with coronary artery disease and erectile dysfunction

Cited by 13 publications

References 31 publications

Basic Concepts of Hemorheology in Microvascular Hemodynamics

Basic Concepts of Hemorheology in Microvascular Hemodynamics

Erythrocyte aggregation: Basic aspects and clinical importance

Obesity and Erectile Dysfunction: Is Androgen Deficiency the Common Link?

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