Association of colorectal adenoma with other malignancies in Swedish families

Abstract

Using the Swedish Family-Cancer Database covering over 11.5 million individuals, estimated relative risks (RRs) for colorectal adenoma were using Poisson's regression. The RR of colorectal adenoma was found to be increased among first-degree relatives of patients with colorectal cancer (2.72; 95% confidence interval ¼ 2.46 -3.00) and among the offspring and siblings of patients with endometrial and prostate cancers. We also found an increased risk of colorectal adenoma for the offspring of individuals with stomach cancer and leukaemia, and for siblings of those with pancreatic cancer and multiple myeloma. Our results suggest that colorectal adenoma may share a genetic aetiology with cancer even at extracolorectal sites. Increases of colorectal adenoma in families affected by prostate cancer and acute leukaemia cannot be attributed to known cancer syndromes, although the play of chance cannot be excluded.

Multiple primary cancers among colorectal cancer survivors in Queensland, Australia, 1996–2007

“…The use of registry based data restricted our ability to quantify the independent effects of several additional risk factors given the Queensland Cancer Registry does not record information on receipt and completion of systemic therapies [16], genetic conditions [30], microsatellite instability [31], family history [47], lifestyle [32,48], environmental exposures [49], and surveillance intensity [50]. In particular, we lacked information to determine what effect, if any, radiation treatment for the first cancer had on the risk of subsequent cancers.…”

Common genetic variants (rs4779584 and rs10318) at 15q13.3 contributes to colorectal adenoma and colorectal cancer susceptibility: evidence based on 22 studies

“…However, previous GWA studies mainly focused on patients with CRC, and it is not known whether the functional variants tagged by these SNPs act through increasing the risk of adenomas, carcinomas, or both. The familial risk of colorectal adenomas is estimated as similar to that of CRCs (Hiripi et al 2008), suggesting that some of the common genetic predisposition to CRC may be mediated through increased adenoma risk. Indeed, adenomas can be regarded as an intermediate phenotype between SNP and cancer (Carvajal-Carmona 2010), and under some plausible scenarios CRC predisposition polymorphisms might be associated more strongly with the risk of colorectal adenoma(s) than with CRC.…”

Much of the Genetic Risk of Colorectal Cancer Is Likely to Be Mediated Through Susceptibility to Adenomas

“…However, all these studies have focused on patients with CRC, and it is not known whether the functional variants tagged by these SNPs act through increasing the risk of adenomas, carcinomas or both. The familial risk of colorectal adenomas is estimated as similar to that of CRCs 9 , suggesting that some of the common genetic predisposition to CRC may be mediated through increased adenoma risk. Indeed, adenomas can be regarded as an intermediate phenotype between SNP and cancer 10 , and under some plausible scenarios, CRC predisposition polymorphisms might be more strongly associated with the risk of colorectal adenoma(s) than with CRC.…”