Multiple primary cancers among colorectal cancer survivors in Queensland, Australia, 1996–2007

Dasgupta, Paramita; Youlden, Danny R.; Baade, Peter D.

doi:10.1007/s10552-012-9990-1

Cited by 12 publications

(12 citation statements)

References 39 publications

(70 reference statements)

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“…In the present study, we demonstrated that the incidence of SPMs is higher in patients with CRC than in the general population (SIR = 1.13). In addition to the SPMs previously reported, 7 , 9 , 10 we found an increased risk for bone and soft tissue cancers in patients with CRC. Of note, opposite risks for a second liver cancer were observed in subgroup analysis.…”

Section: Discussionsupporting

confidence: 68%

“…Stratified age analysis demonstrated that the relative risk for SPMs in patients with CRC decreased progressively with increasing age at the time of initial diagnosis in earlier studies 9 , 11 and the present study. Age is the strongest risk factor for cancer.…”

Section: Discussionsupporting

confidence: 66%

“…A recent study in Australia conducted by Dasgupta et al demonstrated a significant risk of developing non-CRC (SIR = 1.24). 9 Phipps et al used SEER registries and reported a slight but significantly increased risk of sequential non-CRC (SIR = 1.04). 10 Among CRC survivors, an increased risk for bladder, kidney, prostate, stomach, lung, ovarian, breast, and thyroid cancers, as well as melanoma, have been well described in previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that CRC from different primary locations may have SPMs with distinct patterns. 9 , 10 Phipps et al has shown that the incidence of endometrial cancer is elevated in patients with a proximal colon cancer, but not rectal cancer. 10 In the present study, we also found an increased incidence of thyroid and prostate cancers, and hematologic malignancies in patients with colon cancer, whereas subsequent bone and soft tissue cancers occurred more frequently among the rectal cancer group.…”

Section: Discussionmentioning

confidence: 99%

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Incidence of Second Primary Malignancies Following Colorectal Cancer

Lee

Liu

et al. 2015

Medicine

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The purpose of this study is to determine the features of second primary malignancies (SPMs) among patients with prior colorectal cancer (CRC) using a nationwide population-based dataset.Patients with CRC newly diagnosed between 1996 and 2011, and >1 year of follow-up were recruited from the Taiwan National Health Insurance database. Standardized incidence ratios (SIRs) of SPMs in patients with CRC were calculated.During the 16-year study period, 4259 SPMs developed among 98,876 CRC patients. The median duration of follow-up was 4.03 years. The SIR for all SPMs was 1.13 (95% confidence interval = 1.10–1.17). Compared with the general population, a higher incidence of thyroid, prostate, ovarian, and hematologic malignancies developed among patients with colon cancer, whereas the risk for bone and soft tissue cancers increased among patients with rectal cancer. The risk for breast, bladder, kidney, lung, and uterine cancers was significantly higher in patients with colon and rectal cancers than the general population. The risk for liver and biliary tract cancers declined in patients with rectal cancer. Based on multivariate analysis among patients with CRC, age ≥70 years, men, chronic obstructive pulmonary disease (COPD), cirrhosis, and dyslipidemia were independent predictors of an SPM.In conclusion, patients with CRC were at increased risk for a second cancer. The pattern of SPMs was distinct between patients with colon and rectal cancer. Age, men, COPD, cirrhosis, and dyslipidemia were independent risk factors for SPMs. Surveillance and education should be provided for survivors with respect to risk for SPMs.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Incidence of Second Primary Malignancies Following Colorectal Cancer

Lee

Liu

et al. 2015

Medicine

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“…The survival of CRC patients has improved gradually with the widespread use of advanced diagnostic and therapeutic methods, including fecal occult bleeding tests, colonoscopy screening, targeted treatments, and multidisciplinary team therapy approaches. The increased survival rate has resulted in increased risks of developing subsequent primary malignancies, among which the subsequent primary colorectal cancer (SPCRC) was the most commonly observed form of cancer [ 1 , 2 ]. Synchronous colorectal adenoma and family history of CRC are indicators for SPCRC [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

The risk and survival outcome of subsequent primary colorectal cancer after the first primary colorectal cancer: cases from 1973 to 2012

Jiao

et al. 2017

BMC Cancer

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BackgroundAmong colorectal cancer (CRC) survivors, how the prior tumor location affects the risk of subsequent primary colorectal cancer (SPCRC) and the outcome of those suffering from SPCRC remain unknown.MethodsCRC cases diagnosed from 1973 to 2012 were screened for SPCRC development using the Surveillance, Epidemiology, and End Results database. The relative risk of SPCRC was estimated using the standardized incidence ratio. Survivals were analyzed using the Kaplan–Meier and Cox regression model.ResultsThe overall risk of SPCRC increased by 27% in CRC survivors compared to that of the general population. The risk increased in patients with both prior right colon cancer (RCC) and left colon cancer (LCC), and was concentrated in the first 5 years after the prior diagnosis, and among young patients. Among the 6701 SPCRC patients identified, patients with prior RCC were more likely to be elderly, female, and with more low or undifferentiated disease than those with prior LCC or rectal cancer (ReC). The overall survivals differed by both prior tumor location (P < 0.0001) and age (P < 0.0001), and the difference by tumor location remained significant when adjusted or stratified by any other potential prognostic factor except age. The cancer specific survivals differed by age (P < 0.0001) rather than by prior tumor location (P = 0.455).ConclusionsThe overall risk of SPCRC increased among patients with both prior RCC and LCC, but not among those with ReC. The different survival outcomes in CRC survivors suffering from SPCRC were largely explained by the patient age but not by the prior tumor location.Electronic supplementary materialThe online version of this article (10.1186/s12885-017-3765-8) contains supplementary material, which is available to authorized users.

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Risk of extracolonic second primary cancers following a primary colorectal cancer: a systematic review and meta-analysis

Robertson

Baade

et al. 2022

Int J Colorectal Dis

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Purpose The purpose of the study is to assess the global risk of extracolonic secondary primary cancers (SPCs) in patients with colorectal cancer (CRC). Methods Studies of SPC in patients with CRC were included if they reported the standardised incidence ratio (SIR) for extracolonic SPCs in patients with CRC compared with the general population. Pooled summary estimates were calculated using a random-effects model. Results A total of 7,716,750 patients with CRC from 13 retrospective cohort studies that reported extracolonic SPC incidence were included. The overall risk of several SPCs was significantly higher in patients with CRC compared with the general population, including cancers of the urinary bladder (pooled SIR 1.19, 95% confidence interval (CI) 1.06–1.33; p = 0.003), female genital tract (1.88, 1.07–3.31; p = 0.03), kidney (1.50, 1.19–1.89; p = 0.0007), thorax (lung, bronchus and mediastinum) (1.16, 1.01–1.32; p = 0.03), small intestine (4.26, 2.58–7.01; p < 0.0001), stomach (1.22, 1.07–1.39; p = 0.003), and thyroid (1.40, 1.28–1.53; p < 0.0001), as well as melanoma (1.28, 1.01–1.62; p = 0.04). There was also a decreased risk of developing cancer of the gall bladder (0.75, 0.60–0.94; p = 0.01). Conclusion Patients with CRC had a significantly increased risk of extracolonic SPCs compared with the general population. These findings highlight the need to develop research strategies for the management of second primary cancer in patients with CRC.

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Multiple primary cancers among colorectal cancer survivors in Queensland, Australia, 1996–2007

Abstract: While these population-based results do not incorporate all possible risk factors, they form an important foundation from which to further investigate the etiological causes that result in the development of MPCs among colorectal cancer survivors.

Cited by 12 publications

References 39 publications

Incidence of Second Primary Malignancies Following Colorectal Cancer

Incidence of Second Primary Malignancies Following Colorectal Cancer

The risk and survival outcome of subsequent primary colorectal cancer after the first primary colorectal cancer: cases from 1973 to 2012

Risk of extracolonic second primary cancers following a primary colorectal cancer: a systematic review and meta-analysis

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