Association of COL4A3 (rs55703767), MMP-9 (rs17576)and TIMP-1 (rs6609533) gene polymorphisms with susceptibility to type 2 diabetes

Abstract

Abstract. Type 2 diabetes (T2D) is defined by high levels of glucose in the blood. The collagen IV level is associated with conditions of hyperglycemia and insulin resistance. Collagen type IV α3 chain (COL4A3) is a structural protein of the extracellular matrix (ECM). Matrix metallopeptidase 9 (MMP-9) is an enzyme that degrades the extracellular matrix and its activity is moderated by TIMP metallopeptidase inhibitor 1 (TIMP-1). The aim of the current study was to examine the association between genetic polymorphisms of COL4A3 (rs55703767), MMP-9 (rs17576) and TIMP-1 (rs6609533) in patients with T2D. This case-control study was performed on 120 Iranian patients with T2D and 120 healthy individuals. Genotypes were analyzed using the amplification refractory mutation system-polymerase chain reaction technique. The findings demonstrated significant differences between genotypic and allelic distributions of COL4A3 (G/T) and MMP-9 (A/G) polymorphisms as follows: COL4A3 (G/T); TT vs. GG, odds ratio (OR)= 0.235, 95% confidence interval (CI)=0.063-0.0802 (P=0.013) and T vs. G, OR=0.592, 95% CI= 0.371-0.943 (P= 0.026);

Repairing effects of glucosamine sulfate in combination with etoricoxib on articular cartilages of patients with knee osteoarthritis

“…TNF-α can activate and aggregate leukocytes, inhibit the synthesis of type II collagen and proteoglycan, inhibit the self-repair of cartilage, and promote cartilage degradation. MMPs can degrade extracellular matrix of articular cartilage [23,24]. MMP-3 secreted by synovial cells and chondrocytes can not only degrade matrix protein substrates in a variety of extracellular matrix but also activate enzymes such as MMP-9 and MMP-13 to produce a cascade amplification reaction.…”

Repairing effects of glucosamine sulfate in combination with etoricoxib on articular cartilages of patients with knee osteoarthritis

“…TNF-α can activate and aggregate leukocytes, inhibit the synthesis of type II collagen and proteoglycan, inhibit the self repair of cartilage, and promote cartilage degradation. MMPs can degrade extracellular matrix of articular cartilage [18,19]. directly damage the integrity of articular cartilage.…”

Transcriptomic Analysis of the Association Between Diabetes Mellitus and Myocardial Infarction

“…MMP9 (Matrix metalloproteinase 9), belongs to the MMPs family, is involved in matrix degradation and leads to fibrosis and myocyte uncoupling [22]. The A allele of MMP9 (rs17576, A/G) is suggested as a risk factor for T2D [32]. In addition, the rs3918242 polymorphism of MMP9 plays an important role in the development of MI [33].…”