Association of coffee consumption and non-motor symptoms in drug-naïve, early-stage Parkinson's disease

Cho, Bang‐Hoon; Choi, Seong-Min; Kim, Joon‐Tae; Kim, Byeong C.

doi:10.1016/j.parkreldis.2018.02.016

Cited by 29 publications

(17 citation statements)

References 29 publications

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“…In addition to green tea, coffee is also a popular beverage worldwide. Epidemiological studies have shown the lifespan-extending benefits of coffee-consuming habits [78] and the potential of coffee consumption in alleviating the severity of PD [79]. Chlorogenic acid largely presents in both caffeinated and decaffeinated coffee, with a potent free radical scavenging activity and antioxidant effects [80].…”

Section: Polyphenols In Neurodegenerative Diseasesmentioning

confidence: 99%

Dietary Anti-Aging Polyphenols and Potential Mechanisms

Luo

Jia

et al. 2021

Antioxidants

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For years, the consumption of a diet rich in fruits and vegetables has been considered healthy, increasing longevity, and decreasing morbidities. With the assistance of basic research investigating the potential mechanisms, it has become clear that the beneficial effects of plant-based foods are mainly due to the large amount of bioactive phenolic compounds contained. Indeed, substantial dietary intervention studies in humans have supported that the supplementation of polyphenols have various health-promoting effects, especially in the elderly population. In vitro examinations on the anti-aging mechanisms of polyphenols have been widely performed, using different types of natural and synthetic phenolic compounds. The aim of this review is to critically evaluate the experimental evidence demonstrating the beneficial effects of polyphenols on aging-related diseases. We highlight the potential anti-aging mechanisms of polyphenols, including antioxidant signaling, preventing cellular senescence, targeting microRNA, influencing NO bioavailability, and promoting mitochondrial function. While the trends on utilizing polyphenols in preventing aging-related disorders are getting growing attention, we suggest the exploration of the beneficial effects of the combination of multiple polyphenols or polyphenol-rich foods, as this would be more physiologically relevant to daily life.

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Section: Polyphenols In Neurodegenerative Diseasesmentioning

confidence: 99%

Dietary Anti-Aging Polyphenols and Potential Mechanisms

Luo

Jia

et al. 2021

Antioxidants

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“…Coffee has been inversely associated with PD risk [ 180 ]. A cross-sectional study involving treatment-naïve PD patients showed that coffee drinking was significantly associated with a reduced severity in the cognitive domain of the non-motor symptom assessment scale [ 181 ]. In the Parkinson’s Environment and Gene study PD patients also reported on their average caffeinated beverage consumption and ever coffee consumption was associated with less decline in MMSE [ 138 ].…”

Section: Protective Factorsmentioning

confidence: 99%

Cognitive Impairment in Parkinson’s Disease: Epidemiology, Clinical Profile, Protective and Risk Factors

Gonzàlez‐Latapi

Bayram

Litvan

et al. 2021

Behavioral Sciences

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Cognitive impairment is a common non-motor symptom in Parkinson’s Disease (PD) and an important source of patient disability and caregiver burden. The timing, profile and rate of cognitive decline varies widely among individuals with PD and can range from normal cognition to mild cognitive impairment (PD-MCI) and dementia (PDD). Beta-amyloid and tau brain accumulation, oxidative stress and neuroinflammation are reported risk factors for cognitive impairment. Traumatic brain injury and pesticide and tobacco exposure have also been described. Genetic risk factors including genes such as COMT, APOE, MAPT and BDNF may also play a role. Less is known about protective factors, although the Mediterranean diet and exercise may fall in this category. Nonetheless, there is conflicting evidence for most of the factors that have been studied. The use of inconsistent criteria and lack of comprehensive assessment in many studies are important methodological issues. Timing of exposure also plays a crucial role, although identification of the correct time window has been historically difficult in PD. Our understanding of the mechanism behind these factors, as well as the interactions between gene and environment as determinants of disease phenotype and the identification of modifiable risk factors will be paramount, as this will allow for potential interventions even in established PD.

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“…Further research is needed to make specific recommendations about coffee, but preliminary data shows beneficial microbial changes and neuroprotection from coffee consumption. 86 -88…”

Section: Treatment Optionsmentioning

confidence: 99%

The Role of The Gut Microbiome in Parkinson’s Disease

Gallop

Weagley

Paracha

et al. 2021

J Geriatr Psychiatry Neurol

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The gut microbiota is known to play a role in various disease states through inflammatory, immune and endocrinologic response. Parkinson’s Disease is of particular interest as gastrointestinal involvement is one of the earlier features seen in this disease. This paper examines the relationship between gut microbiota and Parkinson’s Disease, which has a growing body of literature. Inflammation caused by gut dysbiosis is thought to increase a-synuclein aggregation and worsen motor and neurologic symptoms of Parkinson’s disease. We discuss potential treatment and supplementation to modify the microbiota. Some of these treatments require further research before recommendations can be made, such as cord blood transplant, antibiotic use, immunomodulation and fecal microbiota transplant. Other interventions, such as increasing dietary fiber, polyphenol and fermented food intake, can be made with few risks and may have some benefit for symptom relief and speed of disease progression.

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Association of coffee consumption and non-motor symptoms in drug-naïve, early-stage Parkinson's disease

Cited by 29 publications

References 29 publications

Dietary Anti-Aging Polyphenols and Potential Mechanisms

Dietary Anti-Aging Polyphenols and Potential Mechanisms

Cognitive Impairment in Parkinson’s Disease: Epidemiology, Clinical Profile, Protective and Risk Factors

The Role of The Gut Microbiome in Parkinson’s Disease

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