Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)

Fong, Pei Yuan; Tan, Sze Huey; Lim, Darren Wan-Teck; Tan, Eng Huat; Ng, Quan Sing; Sommat, Kiattisa; Tan, Daniel S.W.; Ang, Mei‐Kim

doi:10.1371/journal.pone.0224665

Cited by 25 publications

(19 citation statements)

References 44 publications

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“…According to a multi-center study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, tumor stage is a positive predictor of cancer recurrence in HNC patients ( 33 ). Patients with advanced LSCC have an unfavorable prognosis ( 34 ). Most of our patients were stage IV (35.1%), and their 5-yearOS and PFS were 70.2% and 52.1%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Risk Factors for Laryngeal Squamous Cell Carcinoma: A Single-Center Retrospective Study

et al. 2021

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BackgroundThe survival rate of patients with laryngeal squamous cell carcinoma (LSCC) is correlated with several factors. However, the independent prognostic factors of patients with LSCC remain unclear. Thus, we sought to identify prognostic factors affecting LSCC outcomes in the Chinese population.MethodsThe survival and potential prognostic factors of 211 patients with LSCC between April 2011 and July 2019 were retrospectively analyzed. Overall survival (OS) and progression free survival (PFS) were estimated by the Kaplan Meier method, and a log-rank test was used to compare the possible prognostic factors between different groups. The Cox proportional hazard model was used to perform multivariable analysis of significant covariants.ResultsA total of 211 LSCC patients were included, of which 164 (77.7%) were male and 47 (22.3%) were female. Mean age was 62.19 ± 8.328 years. A univariate analysis showed that seven factors including pathological differentiation, clinical stage, tobacco consumption, alcohol consumption, T stage, N stage, and concurrent chemoradiotherapy were correlated with survival (P<0.05). Cox proportional hazards regression analyses revealed that clinic stage (hazard ratio=3.100, p=0.048), pathological differentiation (hazard ratio = 2.538, p=0.015), alcohol consumption (hazard ratio = 8.456, p =0.004) were associated with OS in LSCC. Pathological differentiation (hazard ratio =5.677, p=0.000), alcohol consumption (hazard ratio =6.766, p=0.000) were associated with PFS in LSCC.ConclusionsPathological differentiation, alcohol consumption, are independent prognostic factors and predictors of recurrence in LSCC. These factors could help inform guidelines for clinical treatment and prognosis.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Risk Factors for Laryngeal Squamous Cell Carcinoma: A Single-Center Retrospective Study

et al. 2021

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“…Overall, the 5-year survival rate for patients with HNSCC has remained at 40-60% and is accompanied by a relatively poor prognosis (1,4,5). Laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HPSCC) are two types of HNSCC with high incidence rates and a relatively poor prognosis following treatment (6)(7)(8). Although multiple proteins and pathways have been shown to be associated with the development of LSCC and HPSCC, the exact molecular mechanisms of action and potential therapeutic targets affecting proliferation and migration remain to be elucidated (9).…”

Section: Introductionmentioning

confidence: 99%

The miR‑136‑5p/ROCK1 axis suppresses invasion and migration, and enhances cisplatin sensitivity in head and neck cancer cells

et al. 2021

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Laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HPSCC) are two types of head and neck cancers with high incidence rates and relatively poor prognoses. The aim of the present study was to determine the effects of microRNA (miR/miRNA)-136-5p and its downstream target, Rho-associated coiled-coil containing protein kinase 1 (ROCK1), on LSCC and HPSCC progression and cisplatin sensitivity. The miRNA and protein expression levels in head and neck cancer cell lines were evaluated using reverse transcription-quantitative PCR and western blotting, respectively. MTT, wound healing assays, transwell assays and flow cytometry analysis were performed to measure cell properties. The binding between miR-136-5p and ROCK1 was detected using a dual-luciferase reporter assay. Autophagy double-labeled adenoviral infection assays were used to assess cell autophagy. The results showed that miR-136-5p was expressed in LSCC and HPSCC cells. Functional experiments showed that the expression of miR-136-5p in LSCC and HPSCC cells was negatively correlated with cell viability, invasion and migration. Additionally, miR-136-5p overexpression inhibited epithelial-mesenchymal transition, whereas miR-136-5p knockdown had the opposite effect. Dual-luciferase reporter assays confirmed the targeting relationship between miR-136-5p and ROCK1. miR-136-5p overexpression increased the cisplatin sensitivity of LSCC and HPSCC cells by reducing cell viability, as well as promoting cell apoptosis and autophagy. miR-136-5p overexpression decreased the expression levels of its downstream target ROCK1 and attenuated activity of the Akt/mTOR signaling pathway in cisplatin-treated LSCC and HPSCC cells. Conversely, miR-136-5p knockdown increased ROCK1 levels and decreased cisplatin sensitivity of the LSCC and HPSCC cells by increasing cell viability and inhibiting cell apoptosis, which was reversed by ROCK1 inhibition using the ROCK1 inhibitor, Y27632. Taken together, the results showed that the miR-136-5p/ROCK1 axis inhibits cell invasion and migration, and increases the sensitivity of LSCC and HPSCC cells to cisplatin.

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“…While laryngeal cancer makes up 30-40% of head and neck malignancies and 1-2.5% of all malign cancers [1]. Every year, head and neck cancers are seen in more than half a million people worldwide, and one-fourth of these cases consists of laryngeal squamous cell carcinomas (LSCC) [2]. According to the GLOBOCAN 2018 data, the incidence and mortality rates of laryngeal cancer (100.000 per person, standardized rates according to age) are 3.6/100.000 and 1.9/100.000 in males and; 0.5/100.000 and 0.3/100.000 in females respectively [3].…”

Section: Introductionmentioning

confidence: 99%

The Importance of HSPA-2 Expression in Laryngeal Squamous Cell Carcinomas

Arslan

2021

Preprint

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Objective: Laryngeal Squamous Cell Carcinoma (LSCC) has high recurrence, metastasis and mortality rates, thus determining the markers related to prognosis and the methods that can be effective in its treatment are important. The number of studies on the prognostic role of HSPA in LSCC is very few. We did not find any study investigating the prognostic role of HSPA-2 in LSCC in the literature. The aim of our study was to examine the relationship between HSPA-2 expression and clinicopathological parameters in LSCC.Material and Methods: HSPA-2 was studied on 104 cases who have been diagnosed with LSCC in the last 7 years. The connection between HSPA-2 expression and important prognostic parameters was investigated.Results: In all of the cases, positive immunoreactivity was determined with HSPA-2. A significant relationship was determined between the HSPA-2 expression and important prognostic parameters such as lymphovascular invasion, lymph nodule metastasis, the primary tumor, the TNM stage, recurrence, metastasis and survival rates. Conclusion:Our study supports the link between high HSPA-2 expression levels and poor prognostic parameters. Therefore we think that HSPA-2 can be used as a prognostic marker in laryngeal cancer. Also, we think that HSPA-2 is important in early diagnosis due to its increased expression even in LSCC precursor conditions.

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Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)

Cited by 25 publications

References 44 publications

Evaluation of Risk Factors for Laryngeal Squamous Cell Carcinoma: A Single-Center Retrospective Study

Evaluation of Risk Factors for Laryngeal Squamous Cell Carcinoma: A Single-Center Retrospective Study

The miR‑136‑5p/ROCK1 axis suppresses invasion and migration, and enhances cisplatin sensitivity in head and neck cancer cells

The Importance of HSPA-2 Expression in Laryngeal Squamous Cell Carcinomas

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