Evaluation of Risk Factors for Laryngeal Squamous Cell Carcinoma: A Single-Center Retrospective Study

Zhang, Qihe; Wang, Huanhuan; Zhao, Qin; Zhang, Yuyu; Zheng, Zhuangzhuang; Liu, Shiyu; Liu, Zijing; Meng, Lingbin; Xin, Ying; Jiang, Xin

doi:10.3389/fonc.2021.606010

Cited by 15 publications

(14 citation statements)

References 36 publications

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“…Laryngeal cancer is a general head and neck malignant tumor with a poor prognosis and survival rate ( 24 ). Lifestyle habits comprising drinking and smoking, biliary tract ailments, and gastroesophageal reflux can elevate the laryngeal cancer risks ( 25 , 26 ). Presently, surgical resection along with radio/chemotherapy is the first-line treatment approach for laryngeal cancer.…”

Section: Discussionmentioning

confidence: 99%

Ononin Shows Anticancer Activity Against Laryngeal Cancer via the Inhibition of ERK/JNK/p38 Signaling Pathway

Ma²,

et al. 2022

Front. Oncol.

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BackgroundLaryngeal cancer is a type of head and neck tumor with a poor prognosis and survival rate. The new cases of laryngeal cancer increased rapidly with a higher mortality rate around the world.ObjectiveThe current research work was focused to unveil the in vitro antitumor effects of ononin against the laryngeal cancer Hep-2 cells.MethodologyThe cytotoxic effects of ononin against the laryngeal cancer Hep-2 cells and normal HuLa-PC laryngeal cells were studied using an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The intracellular Reactive Oxygen Species (ROS) generation, apoptotic cell death, Mitochondrial Membrane Potential (MMP), and cell adhesion on the 25 and 50 µM ononin-treated Hep-2 cells were detected using respective staining assays. The levels of TBARS and antioxidants were assayed using specific kits. The expressions of c-Jun N-terminal kinase 1/2 (JNK1/2), Extracellular Signal-regulated Kinase 1/2 (ERK1/2), p38, Phosphatidylinositol-3 Kinase 1/2 (PI3K1/2), and protein kinase-B (Akt) in the ononin-treated Hep-2 cells were investigated using Reverse Transcription-Polymerase Chain Reaction (RT-PCR) assay.ResultsThe ononin treatment effectively inhibited the Hep-2 cell viability but did not affect the viability of HuLa-PC cells. Furthermore, the ononin treatment effectively improved the intracellular ROS accumulation, depleted the MMP, and triggered apoptosis in Hep-2 cells. The Thiobarbituric acid reactive substances (TBARS) were improved, and Glutathione (GSH) levels and Superoxide dismutase (SOD) were depleted in the ononin-administered Hep-2 cells. The ononin treatment substantially inhibited the JNK/ERK/p38 axis in the Hep-2 cells.ConclusionTogether, the outcomes of this exploration proved that the ononin has remarkable antitumor activity against laryngeal cancer Hep-2 cells.

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Section: Discussionmentioning

confidence: 99%

Ononin Shows Anticancer Activity Against Laryngeal Cancer via the Inhibition of ERK/JNK/p38 Signaling Pathway

Ma²,

et al. 2022

Front. Oncol.

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“…Perinöral invazyon, vasküler invazyon ve histolojik diferansiyasyon artmış nodal yayılım ve nüks oranı ile ilişkili olabilen histopatolojik bulgulardır. [16][17][18][19] Çalışmamızda literatürden farklı olarak perinöral invazyon, vasküler invazyon ve histolojik diferansiyasyonun nüks üzerine etkisi bulunmamıştır. Çalışmamızdaki bulguların farklılığını özellikle T3N0 gibi selektif bir gruba yönelik olması ve çalışmadaki olgu sayısının görece düşük olması ve buna bağlı olarak da nüks olgu sayısının düşük sayıda olmasına bağlayabiliriz.…”

Section: Discussionunclassified

Our surgical treatment results in pT3N0 laryngeal squamous cell carcinoma

Duymaz¹

2023

KBB Uygulamaları

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Objectives: This study aimed to evaluate the effect of surgical treatment on disease control, survival rates, and prognostic factors in patients with pT3N0 laryngeal squamous cell carcinoma. Patients and Methods: Files of pT3N0 laryngeal squamous cell carcinoma (LSCC) patients who were surgically treated between January 2009 and December 2019 were retrospectively screened. Forty-four patients (42 males, 2 females; mean age: 59.6±9.2 years; range, 44 to 86 years) diagnosed with pT3N0 LSCC who underwent total laryngectomy or partial laryngectomy as primary treatment were included in the study. Results: The mean follow-up period of the patients was 45.8±38.4 months. The tumor was supraglottic in 20 patients, glottic in 21 patients, and transglottic in three patients. Total laryngectomy was performed in 32 patients, and partial laryngectomy was performed in 12 patients. In five (11.3%) of the patients, recurrence occurred. There was no statistically significant link between recurrence and tumor location, surgical technique, or perineural or lymphovascular invasion. The five-year survival rate was 72.7%, with no differences in survival rates based on the type of surgery performed. Conclusion: Surgical treatment is a safe option for pT3N0 squamous cell carcinoma patients. In patients with appropriate criteria, partial laryngectomy has a similar success to total laryngectomy.

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“…Hal ini sesuai dengan penelitian di China pada tahun 2021 menemukan rerata usia yaitu 62,1 dengan standar deviasi ± 8,3 tahun. 12 Pengelompokkan usia pasien yang terbanyak ditemukan adalah usia 61-70 tahun sebanyak 32,8% serta tidak ditemukan penderita kanker dalam kelompok usia ≤ 40 tahun.…”

Section: Pembahasan Distribusi Frekuensi Pasien Karsinoma Laring Berd...unclassified

Gambaran Klinis dan Terapi Pasien Karsinoma Laring di Departemen THT-KL RSUP Dr. M. Djamil Padang Periode 2017-2021

Putri,

Rahman,

Ilmiawati

2023

JOKLI

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Pendahuluan: Karsinoma laring adalah suatu tumor ganas yang berasal dari sel epitel laring. Faktor risiko utama yang berperan dalam perkembangan penyakit karsinoma laring adalah merokok dan alkohol. Penelitian ini bertujuan untuk mengetahui gambaran klinis dan terapi pasien karsinoma laring di departemen THT-KL RSUP Dr. M. Djamil Padang periode 2017-2021. Desain penelitian ini adalah deskriptif retrospektif yang menggunakan data rekam medis pasien karsinoma laring dengan teknik pengambilan sampel yaitu total sampling yang berjumlah 41 orang. Data pasien kemudian diolah dan ditampilkan dalam bentuk tabel distribusi frekuensi. Penelitian ini mendapatkan hasil bahwa kasus pasien karsinoma laring terbanyak terjadi pada tahun 2017 dan 2018 (31,7%), rerata usia 64 tahun dengan kelompok usia terbanyak 51-60 tahun dan 61-70 tahun (31,7%), lebih banyak pada laki-laki (97,6%), dan mayoritas faktor risiko merokok (95,1%) namun tidak memiliki tiwayat alkohol (92,7%). Keluhan utama tersering suara serak (51,2%). Gejala klinis yang muncul terdiri dari suara serak (73,2%), sesak nafas (65,9%), batuk (56,1%), dan sulit menelan (43,9%). Lokasi paling banyak ditemukan glotis (73,2%), stadium yang sering ditemukan stadium IVA (57,9%), dan tipe histopatologi terbanyak karsinoma sel skuamosa (100%). Jenis terapi yang paling sering diberikan kemoterapi (46,3%). Dapat disimpulkan bahwa pasien karsinoma laring memiliki faktor risiko yang umum dan karakteristik klinik yang tipikal serta sebagian besar datang dalam stadium lanjut. Oleh karena itu diperlukan upaya promotif dan preventif yang lebih agresif terhadap penyakit ini

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Evaluation of Risk Factors for Laryngeal Squamous Cell Carcinoma: A Single-Center Retrospective Study

Cited by 15 publications

References 36 publications

Ononin Shows Anticancer Activity Against Laryngeal Cancer via the Inhibition of ERK/JNK/p38 Signaling Pathway

Ononin Shows Anticancer Activity Against Laryngeal Cancer via the Inhibition of ERK/JNK/p38 Signaling Pathway

Our surgical treatment results in pT3N0 laryngeal squamous cell carcinoma

Gambaran Klinis dan Terapi Pasien Karsinoma Laring di Departemen THT-KL RSUP Dr. M. Djamil Padang Periode 2017-2021

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