Association of circulating resistin, leptin, adiponectin and visfatin levels with Behçet disease: a meta-analysis

Lee, Young Ho; Song, Gwan Gyu

doi:10.1111/ced.13383

Cited by 8 publications

(6 citation statements)

References 46 publications

(114 reference statements)

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“…The current results come in accordance with Lee & Song (2018) who has shown that leptin level was increased significantly in the BD group as compared with the healthy control group. Also Nilufer et al (2007) stated that there were higher serum leptin levels in Behcet's disease group distinguished in accordance to age, sex, and BMI versus the controls.…”

Section: Discussionsupporting

confidence: 92%

“…The elevation of leptin serum levels in patients with Behcet's disease compared to healthy subjects in this study and its close link with several pro-inflammatory mediators underlines the ability of this molecule to stimulate or sustain low-grade inflammation that could be recognized to a possible role for leptin in the pathogenesis of Behcet's diseases and might eventually lead to the development of chronic disease (Lee & Song, 2018).…”

Section: Discussionmentioning

confidence: 58%

“…A few genes were appeared to be linked with existence, progress and seriousness of BD. Behcet's disease is known to be interrelated to apoptosis resistance in T cell subsets and linked with the upregulation of antiapoptotic variables, and this relationship is based on the modulation and the expression of antiapoptotic genes by the activation of NF-κB (Lee & Song, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Serum NF-κB, IL-6, IL-8 and their Relation to Leptin in Patients with Active Behcet’s Disease

Marei

Khattab

2021

Egypt. J. Rad.Sci.

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B EHCET'S DISEASE (BD) is a chronic systemic inflammatory autoimmune disease of unknown cause. It is characterized by elevated levels of proinflammatory cytokines that have been previously reported, yet the pathogenesis is still unknown.Nuclear factor kappa B (NF-κB) is a transcription factor that remain latent in the cytoplasm and shuttles to the nucleus whenever activated. On activation, NF-κB regulates the enzymes cytokines (IL-6, IL-8). NF-κB has been contributing to a wide variety of autoimmune diseases amongst which is BD. NF-κB pathways were involved in the anti-apoptotic activity of leptin in neutrophils in vitro. The present study was conducted to determine serum NF-κB levels, and its role in modulating the expression of different cytokines (IL-6, IL-8) in active BD patients. This is in addition to studying the relationship of leptin with NF-κB, IL-6 and IL-8.The current study included 25 patients with active BD and 25 healthy controls. Serum IL-6, IL-8 and NF-κB levels were measured with quantitative sandwich ELISA kit enzyme-linked immunosorbent assay (ELISA) method, while leptin serum levels were measured using specific radioimmunoassay (RIA) kits.IL-6, IL-8, NF-κB and leptin were significantly higher in BD group than in the control group. Also, there was a positive correlation between IL-8, IL-6, NF-κB and leptin. New insights of the role of leptin in the autoimmune pathophysiology was studied, and its relationship with NF-κB, IL-6 and IL-8 in these patients was detected and might help in elucidation of its pathogenesis. Further studies, are required to encourage the use of anti-NF-κB and anti-Leptin as recent treatment modalities in BD.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Serum NF-κB, IL-6, IL-8 and their Relation to Leptin in Patients with Active Behcet’s Disease

Marei

Khattab

2021

Egypt. J. Rad.Sci.

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“…However, it has been found that resistin plays an important role in inflammation by increasing the secretion of several inflammatory cytokines including TNF-α, CXCL8, IL-12, IL-1β, and IL-6 (108, 109). Interestingly, resistin has been shown to be associated with psoriasis, AD, AN, and Behçet disease (100, 110–112). Concerning the role of resistin in psoriasis, in addition to its effect on proinflammatory cytokine production, its connection with proprotein convertase subtilisin/kexin 9 (PCSK9) may represent another key mechanism.…”

Section: Mechanisms Of Mets and Skin Diseasesmentioning

confidence: 99%

Metabolic Syndrome and Skin Diseases

Zhu

Lian

et al. 2019

Front. Endocrinol.

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The increasing prevalence of Metabolic syndrome (MetS) is a worldwide health problem, and the association between MetS and skin diseases has recently attracted growing attention. In this review, we summarize the associations between MetS and skin diseases, such as psoriasis, acne vulgaris, hidradenitis suppurativa, androgenetic alopecia, acanthosis nigricans, and atopic dermatitis. To discuss the potential common mechanisms underlying MetS and skin diseases, we focus on insulin signaling and insulin resistance, as well as chronic inflammation including adipokines and proinflammatory cytokines related to molecular mechanisms. A better understanding of the relationship between MetS and skin diseases contributes to early diagnosis and prevention, as well as providing clues for developing novel therapeutic strategies.

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“…It has anti-inflammatory, vasculoprotective and insulin-sensitizing effects [76]. Adiponectin has been linked to autoimmune and inflammatory conditions including Behcets’ disease [77], systemic sclerosis [78], psoriasis [79] and IBD.…”

Section: Adipose Tissue and The Pathogenesis Of Ibdmentioning

confidence: 99%

The Role of Adipose Tissue in the Pathogenesis and Therapeutic Outcomes of Inflammatory Bowel Disease

Eder

Adler

Dobrowolska

et al. 2019

Cells

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Though historically regarded as an inert energy store, adipose tissue is a complex endocrine organ, which is increasingly implicated in the pathogenesis of inflammatory bowel disease (IBD). Accumulating evidence points to visceral adipose tissue and specifically to its mesenteric component, or “creeping fat” as impacting on the disease course through its immunomodulatory properties. On the one hand, mesenteric fat acts as a physical barrier to inflammation and is involved in controlling host immune response to translocation of gut bacteria. On the other hand, however, there exists a strong link between visceral fat and complicated course of the disease with unfavorable therapeutic outcomes. Furthermore, “creeping fat” appears to play different roles in different IBD phenotypes, with the greatest pathogenetic contribution probably to an ileal form of Crohn’s disease. In this review, we summarize and discuss the existing literature on the subject and identify high-priority areas for future research. It may be that a better understanding of the role of mesenteric fat in IBD will determine new therapeutic targets and translate into improved clinical outcomes.

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Association of circulating resistin, leptin, adiponectin and visfatin levels with Behçet disease: a meta-analysis

Abstract: Our meta-analysis revealed significantly higher circulating resistin, leptin and adiponectin levels and lower visfatin levels in patients with BD than in HCs, indicating that adipokines probably play an important role in BD pathogenesis.

Cited by 8 publications

References 46 publications

Evaluation of Serum NF-κB, IL-6, IL-8 and their Relation to Leptin in Patients with Active Behcet’s Disease

Evaluation of Serum NF-κB, IL-6, IL-8 and their Relation to Leptin in Patients with Active Behcet’s Disease

Metabolic Syndrome and Skin Diseases

The Role of Adipose Tissue in the Pathogenesis and Therapeutic Outcomes of Inflammatory Bowel Disease

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