Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid

Li, Hui; Mu, Qingshuang; Kang, Yimin; Yang, Xiaoyu; Shan, Ligang; Wang, Meiling; Li, Cunbao; Liu, Yanlong; Wang, Fan

doi:10.3389/fpsyt.2021.738358

Cited by 8 publications

(4 citation statements)

References 68 publications

(73 reference statements)

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“…Most previous studies have shown a direct relationship between smoking and cognitive impairment and dementia (29), while in the present study, older adults who smoke had less cognitive impairment compared to non-smokers. Functional impairment was also lower in smokers than non-smokers.…”

Section: Characteristicscontrasting

confidence: 57%

Prevalence of geriatric syndromes and associated factors in Iranian older adults with type 2 diabetes: A population-based correlational study

Rahimi,

Poortaghi,

Negarandeh

2024

NPT

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Background & Aim: Geriatric syndromes are known as a major obstacle in the treatment and care of older adults with diabetes. This study aimed to determine the prevalence of geriatric syndromes and associated factors in community-dwelling older adults with diabetes in the south of Tehran, Iran, in 2022. Methods & Materials: A population-based correlational study was conducted among 392 older adults with diabetes, covered by selected health centers in the south of Tehran, Iran, using the multistage sampling method. Persian forms of geriatric assessment tools were used, including Mini-Mental State Examination, Activities of Daily Living, Instrumental Activities of Daily Living, Mini Nutritional Assessment, and Geriatric Depression Scale. The obtained data were analyzed by descriptive and chi-square test in SPSS-26. Results: The mean age of the participants was 69.5±6 years (63% female, 37% male). About 54.6% of the older adults with diabetes studied had three or more Geriatric syndromes. Polypharmacy was the most prevalent geriatric syndrome (76.5%). The number of geriatric syndromes had a significant association with female gender (p<0.001), lower education (p<0.001), loss of the spouse (p= 0.004), and lower-income (p=0.019). Also, with the increase in the number of diabetes comorbidities, the occurrence of all geriatric syndromes increased significantly (p<0.001). Conclusion: The prevalence of geriatric syndromes in older adults with diabetes in the south of Tehran is very high and warning. Due to the increasing population of older adults in Iran, policymakers and healthcare providers should take appropriate actions to confront the issue with a comprehensive understanding of the present condition.

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Section: Characteristicscontrasting

confidence: 57%

Prevalence of geriatric syndromes and associated factors in Iranian older adults with type 2 diabetes: A population-based correlational study

Rahimi,

Poortaghi,

Negarandeh

2024

NPT

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“…Especially in the aspect of early signs of diseases, among which disorders of the neurological system might be the first to appear 38 . Studies of Li et al 39 revealed that cigarette smoking might be associated with male cognitive impairment related to higher levels of iron (Fe), zinc (Zn), Pb, and Al in the human cerebrospinal fluid of active smokers.…”

Section: Discussionmentioning

confidence: 99%

Heavy metal concentrations and clinical symptoms in patients diagnosed with schizophrenia related to cigarette smoking

Ghaderi,

Khoshakhlagh,

Gruszecka-Kosowska

et al. 2024

Sci Rep

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In our study, blood concentrations of lead (Pb), arsenic (As), and cadmium (Cd) and urine concentrations of thallium (Tl) were measured together with related symptoms of heavy metal poisoning in cigarette smoking volunteers diagnosed with schizophrenia, in cigarette smokers not diagnosed with schizophrenia, and in the control group of non-smokers and not diagnosed with schizophrenia volunteers. Our study was performed on 171 volunteers divided into the following subgroups: patients diagnosed with schizophrenia with at least 1 year of continuous cigarette smoking experience (56 participants), cigarette smokers not diagnosed with schizophrenia with at least one year of continuous smoking experience (58), and control group (not diagnosed with schizophrenia and non-smoking volunteers) (57). Smoking durations of cigarette smokers diagnosed with schizophrenia and cigarette smokers not diagnosed with schizophrenia are not similar (p = 0.431). Blood Pb, As, and Cd concentrations and urine Tl concentrations were the highest in the subgroup of cigarette smokers not diagnosed with schizophrenia, followed by the subgroup of cigarette smokers diagnosed with schizophrenia, and the control group. Only blood Pb concentrations were significantly higher (probability value p < 0.05) in the group of cigarette smokers not diagnosed with schizophrenia (5.16 μg/dL), comparing to the group of cigarette smokers diagnosed with schizophrenia (3.83 μg/dL) and to the control group (3.43 μg/dL). Blood Cd and As concentrations and urine Tl concentrations were significantly higher (p < 0.05) in cigarette smokers not diagnosed with schizophrenia than in the control group. The results revealed a statistically significant positive correlation (p < 0.001) in the cigarette smokers in the schizophrenia diagnosed group between blood Pb, blood As, and urine Tl concentrations and the duration of cigarette smoking.

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“…Previous studies by Durazzo et al and Pirpamer et al established that former smoking significantly increased the risk for AD from the damage caused by smoking-related cerebral oxidative stress, and identified this as a significant risk factor for cerebral iron accumulation, a habit that is also known to initiate endothelial dysfunction [ 47 , 48 ]. Another cross-sectional study by Li et al found significantly higher cerebrospinal fluid (CSF) iron concentration in active smokers than in non-smokers, suggesting that smoking may accelerate cognitive impairment [ 49 ]. The present study further propagates this knowledge by providing insight into how smoking alters the relationship between dietary iron intake and the incidence of dementia.…”

Section: Discussionmentioning

confidence: 99%

The Association between Dietary Iron Intake and Incidence of Dementia in Adults Aged 60 Years or over in the UK Biobank

et al. 2023

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Background Several studies have investigated the association between dietary iron intake and cognitive impairment, but little is known about the relationship between iron intake and dementia incidence. Objectives This study explored the association between dietary iron intake and incident dementia in males and females. Whether this association was modified by factors such as age and medical diseases was also examined. Methods We included 41,213 males and 48,892 females aged 60 years or over, from the UK-Biobank cohort. Dietary iron intake was measured using a web-based 24-h dietary recall questionnaire from between 2009 and 2012. Incident dementia was ascertained using hospital inpatient records and death registers until April 2021. Cox proportional regression models examined the association between iron intake and incident dementia, and hazard ratio curves were constructed with knots from the analysis indicating insufficient or excessive iron intake. Results During a mean follow-up of 11.8 years, 560 males and 492 females developed dementia. A non-linear relationship between iron intake and incident dementia was observed in both males and females. The lowest incidence rates were observed in the higher iron intake quintile (Q4: ≥15.73, <17.57 mg/day) for males, and the intermediate iron intake quintile (Q3: ≥12.4, <13.71 mg/day) for females. Among those aged 60 and above, all-cause dementia in males was associated with deficient iron intake (Q1 versus Q4: Hazard ratio [HR]: 1.37, 95% Confidence interval [95%CI]: 1.01–1.86, p = 0.042) and excessive iron intake (Q5 versus Q4: HR: 1.49, 95%CI: 1.14–1.96, p = 0.003), whilst significant associations between all-cause dementia and deficient iron intake were only observed in females without hypertension. Smoking status was a significant moderator (p-value for trend = 0.017) for dementia in males only. Conclusions Excessive iron intake (≥17.57 mg/day) is associated with a higher incidence of all-cause dementia in males and smoking status modified this association amongst males. Deficient iron intake (<10.93 mg/day) was associated with a higher incidence of all-cause dementia in females without a history of hypertension.

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Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid

Cited by 8 publications

References 68 publications

Prevalence of geriatric syndromes and associated factors in Iranian older adults with type 2 diabetes: A population-based correlational study

Prevalence of geriatric syndromes and associated factors in Iranian older adults with type 2 diabetes: A population-based correlational study

Heavy metal concentrations and clinical symptoms in patients diagnosed with schizophrenia related to cigarette smoking

The Association between Dietary Iron Intake and Incidence of Dementia in Adults Aged 60 Years or over in the UK Biobank

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