Association of chronic periodontitis and psoriasis: periodontal status with severity of psoriasis

Sharma, Aditi; Raman, Achala; Pradeep, A.R.

doi:10.1111/odi.12271

Cited by 38 publications

(79 citation statements)

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“…A total of 34 of these 40 articles were excluded because they were descriptive studies without comparison groups or did not report the outcomes of interest. One study was excluded because it compared the risk of periodontitis among subjects with and without psoriasis (and did not compare the risk of psoriasis in subjects with and without periodontitis) . Therefore, five studies (two cohort studies and three case–control studies) met the predefined eligibility criteria and were included in the meta‐analysis .…”

Section: Resultsmentioning

confidence: 99%

“…One study was excluded because it compared the risk of periodontitis among subjects with and without psoriasis (and did not compare the risk of psoriasis in subjects with and without periodontitis). 18 Therefore, five studies (two cohort studies and three case-control studies) met the predefined eligibility criteria and were included in the meta-analysis. [19][20][21][22][23] The bibliographies of these five studies were manually reviewed for additional relevant studies, but no further studies were identified.…”

Section: Resultsmentioning

confidence: 99%

“…Even though the exact mechanism behind the increased risk of psoriasis among patients with periodontitis is unknown, several possible explanations have been proposed. One hypothesis is related to the shared pathology between psoriasis and periodontitis, as exaggerated immune responses to the residing microbiota at the epithelial surface are observed in both conditions, which might suggest a shared genetic predisposition affecting dendritic cells and Toll‐like receptor expression . The other possible explanation involves the activation of Th‐17 cells and the increased expression of interleukin 17 (which is one of the major players in the pathogenesis of both psoriasis and psoriatic arthritis) induced by the bacteria involved in periodontal infection and their products …”

Section: Discussionmentioning

confidence: 99%

“…One hypothesis is related to the shared pathology between psoriasis and periodontitis, as exaggerated immune responses to the residing microbiota at the epithelial surface are observed in both conditions, which might suggest a shared genetic predisposition affecting dendritic cells and Toll-like receptor expression. 18,25,26 The other possible explanation involves the activation of Th-17 cells and the increased expression of interleukin 17 (which is one of the major players in the pathogenesis of both psoriasis and psoriatic arthritis) induced by the bacteria involved in periodontal infection and their products. 25,26 It would be informative to analyse whether patients with psoriasis associated with periodontitis have a higher (or lower) risk of developing psoriatic arthritis compared to the overall psoriatic population.…”

Section: Identification and Verification Of Periodontitismentioning

confidence: 99%

See 3 more Smart Citations

Periodontitis and risk of psoriasis: a systematic review and meta‐analysis

Ungprasert

Wijarnpreecha

Wetter

2016

Acad Dermatol Venereol

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Background The association between periodontitis and systemic diseases has been increasingly recognized. However, the data on the association between periodontitis and psoriasis are still limited. Objectives To summarize all available data on the association between periodontitis and the risk of psoriasis. Methods Two investigators independently searched published studies indexed in MEDLINE and EMBASE databases from inception to July 2016 using a search strategy that included terms for psoriasis and periodontitis. Studies were included if the following criteria were met: (1) Case-control or cohort study comparing the risk of psoriasis in subjects with and without periodontitis ;(2) subjects without periodontitis were used as comparators in cohort studies while participants without psoriasis were used as controls in case-control studies; and (3) effect estimates and 95% confidence intervals (CI) were provided. Point estimates and standard errors from each study were extracted and combined together using the generic inverse variance technique described by DerSimonian and Laird. Results Two cohort studies and three case-control studies met the inclusion criteria and were included in the meta-analysis. The pooled risk ratio of psoriasis in patients with periodontitis versus comparators was 1.55 (95% CI, 1.35–1.77). The statistical heterogeneity was insignificant with an I2 of 18%. Subgroup analysis according to study design revealed a significantly higher risk among patients with periodontitis with a pooled RR of 1.50 (95% CI, 1.37 – 1.64) for cohort studies and a pooled RR of 2.33 (95% CI, 1.51 – 3.60) for case-control studies. Conclusions Patients with periodontitis have a significantly elevated risk of psoriasis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Identification and Verification Of Periodontitismentioning

confidence: 99%

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Periodontitis and risk of psoriasis: a systematic review and meta‐analysis

Ungprasert

Wijarnpreecha

Wetter

2016

Acad Dermatol Venereol

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“…Eight of these, with between 33 and 115,365 cases, found measures of periodontitis including probing depth and CAL were increased in those with psoriasis compared to controls [95,[100][101][102][103][104][105][106]. A large population cohort study concluded that self-reported alveolar bone loss and loss of teeth increased risk of subsequent psoriasis [104].…”

Section: Periodontitis and Psoriatic Arthritismentioning

confidence: 99%

Periodontal Disease and Autoimmunity: What We Have Learned from Microbiome Studies in Rheumatology

Rutter-Locher¹,

Fuggle²,

Orlandi³

et al. 2017

Periodontitis - A Useful Reference

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The oral cavity is home to vast populations of commensal microbial organisms which constitute the 'healthy oral microbiome.' Periodontitis is a destructive, infectious, inflammatory condition affecting the gums. Initially, a biofilm structure develops, causing localized inflammation. This biofilm is then colonized by certain anaerobic bacteria, including the 'red complex' organisms. There is an increasing interest in the communication between these organisms and host immune surveillance, a dialog which may plays an important role in the development of autoimmune diseases. Studies have shown an association between periodontitis and other inflammatory conditions including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and systemic lupus. The advent of accessible 16S ribosomal sequencing has led to exciting developments in the characterization of the human microbiome and the ability to study this interaction in more detail. The transmucosal communication between periodontitis and host immunity may provide avenues of discovery regarding the etiology and progression of rheumatic diseases.

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Oral health in patients with severe inflammatory dermatologic and rheumatologic disease

Kiernan

O’Connor

Ryan

et al. 2022

Skin Health and Disease

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Background Poor oral health (OH) is a risk factor for systemic disease and lower quality of life (QoL). Patients with inflammatory dermatologic/rheumatologic diseases report more oral discomfort, dry mouth, and periodontal disease than controls. Medications used to treat these conditions can also adversely affect OH. Objectives The aim was to assess the OH of patients with chronic inflammatory dermatologic/rheumatologic diseases treated with systemic/biologic therapy, compared to controls. Methods Patients with chronic inflammatory dermatologic/rheumatologic diseases treated with systemic/biologic therapy were recruited from outpatient clinics across two university hospitals. All patients had a standardized World Health Organisation OH assessment performed consisting of an OH exam and questionnaire. Age‐ and sex‐matched controls without chronic inflammatory disease were recruited from a pigmented lesion clinic. Charts of patients with chronic inflammatory dermatologic/rheumatologic diseases were reviewed to assess OH documentation. Results One hundred patients were examined (50 cases and 50 controls). Patients with inflammatory dermatologic/rheumatologic diseases (cases) had poorer periodontal status (mean loss of attachment 6.9 mm vs. 1.9 mm controls, p = 0.01), more missing teeth (mean 7.7 vs. 4.4 controls, p = 0.029), more dry mouth (82% vs. 20% controls, p = 0.001), and less frequent tooth brushing (60% vs. 80% controls, p = 0.037). Of 250 patient charts which were reviewed, 98.4% (n = 246) had no documentation of OH. Conclusion Patients with severe inflammatory dermatologic/rheumatologic conditions have poorer OH and OH‐related QoL. Clinicians should appreciate the risk of poor OH in this cohort and have a low threshold for involving OH professionals in care pathways for severe inflammatory disease.

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Association of chronic periodontitis and psoriasis: periodontal status with severity of psoriasis

Abstract: The results showed a link between CP and psoriasis. This suggests the need for a multidisciplinary approach to manage psoriasis patients with chronic periodontitis, especially in relation to current and future treatment.

Cited by 38 publications

References 50 publications

Periodontitis and risk of psoriasis: a systematic review and meta‐analysis

Periodontitis and risk of psoriasis: a systematic review and meta‐analysis

Periodontal Disease and Autoimmunity: What We Have Learned from Microbiome Studies in Rheumatology

Oral health in patients with severe inflammatory dermatologic and rheumatologic disease

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