Association of chronic obstructive pulmonary disease with mild cognitive impairment and dementia risk: A systematic review and meta-analysis

Abstract

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a common public health issue that has been linked to cognitive dysfunction. AIM To investigate the relationship between COPD and a risk of mild cognitive impairment (MCI) and dementia. METHODS A comprehensive literature search of the PubMed, Embase, Google Scholar, and Cochrane Library electronic databases was conducted. Pooled odds ratios (OR) and mean differences (MD) with 95% confidence intervals (CIs) were calculated using a random or fixed effects model. Studies that met the inclusion criteria were assessed for quality using the Newcastle Ottawa Scale. RESULTS Twenty-seven studies met all the inclusion criteria. Meta-analysis yielded a strong association between COPD and increased risk of MCI incidence (OR = 2.11, 95%CI: 1.32-3.38). It also revealed a borderline trend for an increased dementia risk in COPD patients (OR = 1.16, 95%CI: 0.98-1.37). Pooled hazard ratios (HR) using adjusted confounders also showed a higher incidence of MCI (HR = 1.22, 95%CI: -1.18 to -1.27) and dementia (HR = 1.32, 95%CI: -1.22 to -1.43) in COPD patients. A significant lower mini-mental state examination score in COPD patients was noted (MD = -1.68, 95%CI: -2.66 to -0.71). CONCLUSION Our findings revealed an elevated risk for the occurrence of MCI and dementia in COPD patients. Proper clinical management and attention are required to prevent and control MCI and dementia incidence in COPD patients.

review of variable risk factors affecting the development of mild cognitive impairment in older adults

“…COPD is expected to be the third leading cause of death by 2030 [82]. A recent systematic review and meta-analysis found a strong correlation between COPD and increased incidence of MCI (OR = 2.11, 95%CI: 1.32-3.38) [83]. Other researchers have suggested that the prevalence of cognitive dysfunction in COPD patients is about 56.7%, four times higher than in non-COPD patients, including attention, learning, processing speed, visuospatial memory, language, and executive functioning [84].…”

Acceptance and adherence to non-invasive positive pressure ventilation in people with chronic obstructive pulmonary disease: a grounded theory study

“…functions (Simargi et al, 2022;Zhao and Zhou, 2022), anxiety (Martínez-Gestoso et al, 2022), and depression (Peiffer et al, 2021;Martínez-Gestoso et al, 2022). Long-term Oxygen Therapy (LTOT) has been found to improve the quality of life (Pavlov et al, 2018).…”