Trends in prevalence and the effects on hospital outcomes of dementia in patients hospitalized with acute COPD exacerbation

Miguel-Díez, Javier de; López‐de‐Andrés, Ana; Jiménez‐García, Rodrigo; Hernández-Barrera, Valentín; Carabantes-Alarcón, David; Zamorano-León, José J.; Omaña-Palanco, Ricardo; Barcala, Francisco Javier González; Cuadrado-Corrales, Natividad

doi:10.1016/j.rmed.2023.107223

Cited by 4 publications

(11 citation statements)

References 48 publications

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“…The studies included eleven with the outcome of mortality [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ] and eleven with the outcome of hospitalization for AECOPD [ 22 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Dang et al reported the outcomes of mortality and hospitalization rates for AECOPD [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…Dang et al reported the outcomes of mortality and hospitalization rates for AECOPD [ 22 ]. Twelve studies had a European research region, including France, Germany, Hungary, Malta, Portugal, Slovenia, Spain, Türkiye, and the United Kingdom [ 23 , 24 , 25 , 28 , 29 , 30 , 32 , 33 , 34 , 35 , 36 , 37 ]. There were eleven multicenter [ 22 , 23 , 25 , 26 , 28 , 29 , 30 , 32 , 35 , 39 , 40 ] and ten single-center studies.…”

Section: Resultsmentioning

confidence: 99%

“…Twelve studies had a European research region, including France, Germany, Hungary, Malta, Portugal, Slovenia, Spain, Türkiye, and the United Kingdom [ 23 , 24 , 25 , 28 , 29 , 30 , 32 , 33 , 34 , 35 , 36 , 37 ]. There were eleven multicenter [ 22 , 23 , 25 , 26 , 28 , 29 , 30 , 32 , 35 , 39 , 40 ] and ten single-center studies. Fifteen studies were observational cohort studies [ 21 , 22 , 23 , 24 , 25 , 26 , 28 , 29 , 32 , 34 , 35 , 37 , 38 , 39 ], and six studies were letters or conference abstracts [ 20 , 27 , 30 , 34 , 37 , 40 ] ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…There were eleven multicenter [ 22 , 23 , 25 , 26 , 28 , 29 , 30 , 32 , 35 , 39 , 40 ] and ten single-center studies. Fifteen studies were observational cohort studies [ 21 , 22 , 23 , 24 , 25 , 26 , 28 , 29 , 32 , 34 , 35 , 37 , 38 , 39 ], and six studies were letters or conference abstracts [ 20 , 27 , 30 , 34 , 37 , 40 ] ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

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Chronic Obstructive Pulmonary Disease Mortality and Hospitalization during the COVID-19 Pandemic Compared with before the Pandemic: A Systematic Review and Meta-Analysis

Ahn,

Park

2024

JPM

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This study aimed to assess the impact of the pandemic on hospitalization and mortality rates among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We conducted a systematic search across three medical databases for studies comparing the AECOPD mortality and hospitalization rates during the COVID-19 pandemic with those before the pandemic, up until December 2023. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Meta-analysis of Observational Studies in Epidemiology guidelines, we performed a meta-analysis with a random-effects model to pool odds ratios (ORs), 95% confidence intervals (CIs), and heterogeneity (I2). From 4689 records, 21 studies met our inclusion criteria. Our analysis revealed a significant increase in in-hospital mortality during the pandemic (pooled OR = 1.27, 95% CI = 1.17–1.39, I2 = 50%). Subgroup analysis highlighted a more pronounced mortality risk in single-center studies and smaller populations. Conversely, hospitalization rates for AECOPD significantly declined during the pandemic (pooled OR = 0.39, 95% CI = 0.18–0.85, I2 = 99%). The study demonstrates that during the COVID-19 pandemic, there was a substantial decrease in hospital admissions for AECOPD and an increase in in-hospital deaths. This shows that better healthcare plans and pandemic preparedness are needed to help people with chronic conditions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Chronic Obstructive Pulmonary Disease Mortality and Hospitalization during the COVID-19 Pandemic Compared with before the Pandemic: A Systematic Review and Meta-Analysis

Ahn,

Park

2024

JPM

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“… 4 While the incidence of cardiovascular disease and emphysema tends to be lower in women compared to men, the incidence of lung cancer is lower in women, and the mortality rate among exacerbation patients is also lower compared to men. 19 , 20 …”

Section: Introductionmentioning

confidence: 99%

Management Reality of Female Patients with COPD: A Multicenter Cross-Sectional CAP Study in Japan

Yamamoto,

Oishi,

Ohata

et al. 2024

COPD

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Background Reports from Europe and North America suggest that female chronic obstructive pulmonary disease (COPD) patients have a higher symptom burden and mortality than male patients. However, little is known about the management reality of female patients with COPD in Japan. Patients and Methods We compared the clinical characteristics of female COPD patients with those of male using the cohort of the COPD Assessment in Practice study, which is a cross-sectional multicenter observational study. Results Of the 1168 patients, 133 (11.4%) were female. A history of never smoking was higher in females than males (p<0.01). Although there was no difference in age or forced expiratory volume in one second (FEV 1 ) % predicted between the groups, modified medical research council dyspnea scale (mMRC) and number of frequent exacerbators were higher in females (mMRC≥2: p<0.01; number of exacerbations≥2: p=0.011). The mean forced vital capacity and FEV 1 values in females were lower than those in males (p<0.0001 and p<0.0001, respectively). Females were more likely to use long-term oxygen therapy and inhaled corticosteroids than males (p=0.016 and p<0.01, respectively). The prevalence of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups B, C, D (ABCD GOLD 2017 classification), and E (ABE GOLD 2023 classification) was higher in females than in males. Conclusion The disease burden of female patients with COPD is higher than that of male patients in Japan, suggesting the importance of interventions considering female-dominant features such as lower absolute FVC and FEV 1 , respiratory failure, and asthma-like conditions.

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COVID-19 Hospitalization Outcomes for Long-Term Care Facility Residents With Dementia: Mediation by Pre-existing Health Conditions

Yin,

Mpofu,

Brock

et al. 2024

Gerontology and Geriatric Medicine

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Background: This study explores COVID-19 emergency admission and length of hospital stay hospitalization outcomes for Long-Term Care Facility (LTCF) residents with dementia. Methods: Utilizing a cross-sectional case control design, we employed logistic regression to analyze Texas Inpatient Public Use Data File (PUDF) for 1,413 dementia patients and 1,674 non-dementia patients (>60 years) to predict emergency admission and length of hospital stay with mediation by pre-existing conditions. Results: LTCF residents with dementia have a higher likelihood of COVID-19 emergency admission and shorter hospital stays. Adjusting for confounders of demographics, health insurance, and lifestyle, dementia diagnosis remained significantly associated with emergency admission and shorter hospital stays with preexisting conditions. Conclusion: Findings underscore the heightened risk for adverse COVID-19 hospitalization care disparities with dementia. Targeted health support programs for LTCF residents with dementia should aim to improve their COVID19 hospitalization outcomes, treating pre-existing health conditions and reducing their risk for excess mortality.

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Trends in prevalence and the effects on hospital outcomes of dementia in patients hospitalized with acute COPD exacerbation

Cited by 4 publications

References 48 publications

Chronic Obstructive Pulmonary Disease Mortality and Hospitalization during the COVID-19 Pandemic Compared with before the Pandemic: A Systematic Review and Meta-Analysis

Chronic Obstructive Pulmonary Disease Mortality and Hospitalization during the COVID-19 Pandemic Compared with before the Pandemic: A Systematic Review and Meta-Analysis

Management Reality of Female Patients with COPD: A Multicenter Cross-Sectional CAP Study in Japan

COVID-19 Hospitalization Outcomes for Long-Term Care Facility Residents With Dementia: Mediation by Pre-existing Health Conditions

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