Association of chronic hepatitis B virus infection with age‐related macular degeneration

Abstract

PurposeTo study the association between chronic hepatitis B virus (HBV) and age‐related macular degeneration (AMD).MethodsData used in this retrospective, frequency‐matched cohort study were acquired from the Longitudinal Health Insurance Database 2000, which includes medical claims and registration files for 1 000 000 enrolees in the Taiwan National Health Insurance programme. The HBV cohort contained 17 796 patients who received a diagnosis of chronic HBV infection between January 1, 2000 and December 31, 2012. The non‐HBV cohort contained 71 184 participants who were frequency‐matched by age, sex and year of index date for comparison. Participants were followed until the end of 2013, and those who developed AMD during the study period were identified. A Cox proportional hazards regression model was used to compare the risk of AMD between cohorts.ResultsThe incidence of any type of AMD in all participants was 3.88 per 1000 person‐years (PY; 2.27 per 1000 PY in the HBV cohort; 1.61 per 1000 PY in the non‐HBV cohort). Compared with the non‐HBV cohort, the adjusted hazard ratio (HR) for any type of AMD in the HBV cohort was 1.41 [95% confidence interval (CI) 1.23–1.63; p < 0.001]. This significant positive association was stronger among patients who exhibited disease progression from nonexudative to exudative AMD (adjusted HR = 1.74, 95% CI: 1.01–2.99).ConclusionOur results suggest that patients with chronic HBV infection in Taiwan have a significantly elevated risk of developing any type of AMD and that HBV infection may accelerate the progression of AMD.

The Use of Electronic Medical Records-Based Big-Data Informatics to Describe ALT Elevations Higher than 1000 IU/L in Patients with or without Hepatitis B Virus Infection

“…Several studies demonstrated that daily aspirin treatment may be associated with a reduced risk of HBV-related HCC occurrence and recurrence, and liver-related mortality [22,23]. Thus, it is useful to use big data in the analysis HBV infection to establish new findings regarding the association between HBV infection and other diseases [24,25].…”

Association between age‐related macular degeneration and periodontal and peri‐implant diseases: a systematic review

“…Similarly, Gemmy Cheung et al (2013) reported that an increased body mass index (BMI) and state of hypertension are risk factors for AMD. Moreover, the prevalence of hepatitis‐B is significantly higher in the Korean population compared with other Asian countries (Cho et al 2014; La et al 2014), and hepatitis‐B is by itself a risk factor of AMD (Wu et al 2019). Here, it is pertinent to mention that systemic diseases including DM, hepatitis‐B and increased BMI are also risk factors of periodontal and peri‐implant diseases (Javed et al 2007; Javed et al 2015; Vohra et al 2018; Javed & Romanos 2019).…”

Increased incidence of age-related macular degeneration in sensorineural hearing loss: A population-based cohort study

“…Moreover, the incidence of AMD in the study group is also numerically higher than the general incidence of AMD from the same population. [32] Since both SNHL and AMD affect a large percentage of population, a routinely ophthalmic examination can be recommended for patients that diagnosed with SNHL.…”