Association of Chemotherapy Timing in Pregnancy With Congenital Malformation

Gerwen, Mathilde van; Maggen, Charlotte; Cardonick, Elyce; Verwaaijen, Emma J.; Heuvel‐Eibrink, Marry van den; Shmakov, Roman; Boere, Ingrid; Gzirí, Mina Mhallem; Ottevanger, Petronella B.; Lok, Christianne; Halaška, Michael; Shao, Long Ting; Struys, Ilana; Dijk-Lokkart, Elisabeth M. van; Calsteren, Kristel Van; Fruscio, Robert; Zola, Paolo; Scarfone, Giovanna; Amant, Frédéric

doi:10.1097/01.ogx.0000802680.45004.84

Cited by 8 publications

(14 citation statements)

References 5 publications

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“…A study of 755 pregnant women with cancer found that the occurrence of major congenital malformations was highest when the first chemotherapy cycle was initiated before 12 weeks of gestation. 29 In our study, women hospitalised for cancer treatment in the first trimester tended to have a greater risk of birth defects than patients treated for malignancies later on.…”

Section: Discussionmentioning

confidence: 54%

“…Findings for prepregnancy cancer contrast with the more apparent association between cancer during pregnancy and birth defects. The literature remains mixed on these associations 24–30 . A registry of 231 women with cancer during pregnancy found that 3.8% of patients had offspring with birth defects, essentially equivalent to the rate in the general population 24 .…”

Section: Discussionmentioning

confidence: 99%

“…The literature remains mixed on these associations. [24][25][26][27][28][29][30] A registry of 231 women with cancer during pregnancy found that 3.8% of patients had offspring with birth defects, essentially equivalent to the rate in the general population. 24 Several studies have found no difference in the incidence of congenital malformations in women with cancer during pregnancy compared with no cancer.…”

Section: Discussionmentioning

confidence: 99%

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Association of maternal cancer with congenital anomalies in offspring

Auger,

Maniraho,

Ayoub

et al. 2023

Paediatric Perinatal Epid

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BackgroundCongenital anomalies are common, but the possibility that maternal cancer increases the chance of having a child with a birth defect is not fully understood.ObjectivesTo examine the association between maternal cancer before or during pregnancy and the risk of birth defects in offspring.MethodsWe conducted a retrospective cohort study of live births in Quebec, Canada, between 1989 and 2022 using hospital data. The main exposure measure was maternal cancer before or during pregnancy. The outcome included birth defects detected in offspring during gestation or at birth. We estimated risk ratios (RR) and 95% confidence intervals (CI) for the association of maternal cancer with birth defects using log‐binomial regression models adjusted for potential confounders.ResultsIn this study of 2,568,120 newborns, birth defects were present in 6.0% and 6.7% of infants whose mothers had cancer before or during pregnancy, respectively, compared with 5.7% of infants whose mothers never had cancer. Cancer during pregnancy was associated with heart (RR 1.58, 95% CI 1.03, 2.44), nervous system (RR 4.05, 95% CI 2.20, 7.46) and urinary defects (RR 1.72, 95% CI 1.01, 2.95). Among specific types of malignancies during pregnancy, breast cancer was the most prominent risk factor for birth defects (RR 1.55, 95% CI 1.02, 2.37). Cancer before pregnancy was not associated with any type of birth defect or with defects overall (RR 1.01, 95% CI 0.92, 1.11). Moreover, no specific type of cancer before pregnancy was associated with an increased risk of birth defects.ConclusionsMaternal cancer during pregnancy is associated with the risk of congenital anomalies in offspring, however, cancer before pregnancy is not associated with this outcome.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association of maternal cancer with congenital anomalies in offspring

Auger,

Maniraho,

Ayoub

et al. 2023

Paediatric Perinatal Epid

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“…Chemotherapy and resulting metabolites may be detected in semen and vaginal secretions after administration [48–52]. Moreover, a recent study found that chemotherapy was associated with an increased risk of major congenital malformations in the first 12 weeks of pregnancy [53 ▪▪ ].…”

Section: Addressing Sexual Dysfunction In Adolescent and Young Adult ...mentioning

confidence: 99%

Sexual dysfunction among adolescent and young adult cancer patients: diagnostic and therapeutic approach

Nesher

Luria

Shachar

et al. 2022

Current Opinion in Supportive &Amp; Palliative Care

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Purpose of reviewWe present a review for healthcare professionals, formulated by a multidisciplinary team, for screening and interventions, describing common sexual impairments encountered by adolescent and young adult cancer patients (AYACP), and suggest a comprehensive evidence-based assessment approach and interventions for treatment of sexual dysfunction (SD).Recent findingsWe discuss the various aspects of SD in AYACP, including causes, challenges and etiologies, and then go on to recommend increased awareness and guidance in healthcare workers, in order to optimize diagnosis and treatment of SD.SummaryAlthough the extent of SD among AYACP is widely recognized, oncological clinicians rarely address SD in their routine practice, lacking a clear approach of interdisciplinary diagnostic and therapeutic interventions. Here, we suggest guiding clinical management to optimize treatment quality.

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“…In addition, her physicians have counseled her that she would most likely require postoperative chemotherapy, which is associated with an increased risk of induced congenital malformations. 1 The first decision she makes is to end the pregnancy. The patient's grief related to the cancer diagnosis and the decision to end the pregnancy is incalculable.…”

mentioning

confidence: 99%