Association of chairside salivary aMMP-8 findings with periodontal risk assessment parameters in patients receiving supportive periodontal therapy

Abstract

PurposeThe aim of this retrospective cross-sectional study was to evaluate whether salivary findings of active matrix-metalloproteinase 8 (aMMP-8) chairside (point of care; POC) tests were associated with periodontal risk assessment parameters in patients receiving supportive periodontal therapy (SPT).MethodsA total of 125 patients receiving regular SPT were included, and their records were examined. The following inclusion criteria were used: a diagnosis of chronic periodontitis, at least 1 non-surgical periodontal treatment (scaling and root planning) with following regular SPT (minimum once a year), at least 6 remaining teeth, and clinical and aMMP-8 findings that were obtained at the same appointment. In addition to anamnestic factors (e.g., smoking and diabetes), oral hygiene indices (modified sulcus bleeding index [mSBI] and approximal plaque index), periodontal probing depth simultaneously with bleeding on probing, and dental findings (number of decayed, missing, and filled teeth) were recorded. Salivary aMMP-8 levels were tested using a commercial POC test system (Periomarker, Hager & Werken, Duisburg, Germany). Statistical analysis was performed using the t-test, Mann-Whitney U test, Fisher's exact test, and χ2 test, as appropriate (P<0.05).ResultsOnly the mSBI was significantly associated with positive salivary aMMP-8 findings (aMMP-8 positive: 27.8%±20.9% vs. aMMP-8 negative: 18.0%±14.5%; P=0.017). No significant associations were found between aMMP-8 and smoking, diabetes, periodontal parameters, or parameters related to the maintenance interval (P>0.05).ConclusionsSalivary aMMP-8 chairside findings were not associated with common parameters used for periodontal risk assessment in patients receiving SPT. The diagnostic benefit of POC salivary aMMP-8 testing in risk assessment and maintenance interval adjustment during SPT remains unclear.

Changing the Focus to the Whole Patient instead of One Oral Disease: The Concept of Individualized Prevention

“…Additionally, epigenetic markers, such as noncoding RNAs, would be a potential future perspective [78]. Furthermore, although their recent diagnostic benefit for prevention has not been completely clarified, matrix metalloproteinase in gingival crevicular fluid or in saliva could be promising [79,80]. e consideration of an individual needs profile, with a differentiation between the risk of pathogenesis and…”

Diagnostic ability of salivary matrix metalloproteinase‐9 lateral flow test point‐of‐care test for periodontitis

“…However, in terms of inflammation, it could be more critical to control both pro-and active form of MMP-9 for the prevention of periodontitis. Further studies clarify the diagnostic, predictive and prognostic ability of pro (Schmalz et al, 2018). Hence, we considered these factors as covariates and developed an algorithm with higher diagnostic ability for periodontitis using a multivariable logistic regression model.…”

“…Moreover, periodontitis and periodontitis‐related systemic diseases have common risk factors encompassing age, sex smoking and obesity in patients (Schmalz et al., 2018). Hence, we considered these factors as covariates and developed an algorithm with higher diagnostic ability for periodontitis using a multivariable logistic regression model.…”

Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic

“…The lower sensitivity (35%) assessed by Deng et al [ 18 ] was eventually due to their periodontally healthier patient cohort with lesser clinical disease activity in comparison to cohort with enhanced clinical disease activities by Lähteenmäki et al [ 10 ] and Sorsa et al [ 4 , 6 ]. Thus in patients on maintenance therapy or in those with low disease activity, aMMP-8 values are known to be lower [ 15 , 16 , 18 ] than those in patients with more enhanced periodontal clinical disease activity [ 4 , 6 , 10 , 22 , 24 ].…”