Association of CEA, NSE, CYFRA 21-1, SCC-Ag, and ProGRP with Clinicopathological Characteristics and Chemotherapeutic Outcomes of Lung Cancer

Bi, Huijuan; Yin, Li; Fang, Wenhao; Song, Shenglan; Wu, Shan; Shen, Jilu

doi:10.1093/labmed/lmac122

Cited by 16 publications

(9 citation statements)

References 22 publications

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“…However, in the differential diagnosis and efficacy evaluation of malignant tumors, CEA is still important. Increased CEA in non-small cell lung cancer patients indicates that recurrence and metastasis are more likely to occur, and recent studies have shown that CEA is valuable for predicting prognosis in non-small cell lung cancer patients (15)(16)(17)(18). The TNM staging system is used to comprehensively evaluate the stage of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Establishment and validation of a long-term prognosis prediction model for patients with non-small cell lung cancer

Yu¹,

Tan²,

Xu³

2023

J Thorac Dis

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Background: The incidence of non-small cell lung cancer ranks second among malignant tumors, while the mortality rate ranks first. We established a prediction model for the long-term prognosis of lung cancer patients to accurately identify patients with a high risk of postoperative death and provide a theoretical basis for improving the prognosis of patients with non-small cell lung cancer. Methods:The data of 277 non-small cell lung cancer patients who underwent radical lung cancer resection at Shanghai Fengxian District Central Hospital between January 2016 and December 2017 were retrospectively collected. The patients, who were followed up for 5 years, were divided into a deceased group (n=127) and survival group (n=150) according to whether the patients had died 5 years after surgery or not. The clinical characteristics of the two groups were observed, and the risk factors of death within 5 years of surgery in lung cancer patients were analyzed. A nomogram predictive model was then established to analyze the value of the model in predicting the death within 5 years of surgery in patients with non-small cell lung cancer.Results: Multivariate logistics regression analysis showed that carcinoembryonic antigen (CEA) >193.5 ng/mL, stage III lung cancer, peritumor invasion, and vascular tumor thrombus were independent risk factors of tumor-specific death after surgery in patients with non-small cell lung cancer (P<0.05). R 4.0.3 statistical software was used to randomly divide the dataset into a training set and validation set. The sample size of the training set was 194, and the sample size of the validation set was 83. The area under the receiver operating characteristic (ROC) curve was 0.850 [95% confidence interval (CI): 0.796-0.905] in the training set, and it was 0.779 (95% CI: 0.678-0.880) in the validation set. In the validation set, the model was assessed using the Hosmer-Lemeshow goodness-of-fit test, with a chi-square value of 9.270 and a P value of 0.320.Conclusions: Our model could accurately identify high risk of death within 5 years of surgery in nonsmall cell lung cancer patients. Strengthening the management of high-risk patients may help improve the prognosis of these patients.

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Section: Discussionmentioning

confidence: 99%

Establishment and validation of a long-term prognosis prediction model for patients with non-small cell lung cancer

Yu¹,

Tan²,

Xu³

2023

J Thorac Dis

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“…The detection of tumor markers in the blood has certain reference values for tumor screening and diagnosis. Tumor markers in the gastrointestinal tract mainly include CEA, CA19-9, CA125, and CA72-4, of which CEA has the highest sensitivity ( 23 – 26 ), and tumor markers in lung cancer include CEA, CYFRA21-1, SCC, and NSE ( 27 ). In our case, tumor markers were elevated in both the gastrointestinal tract and the lung, indicating that the tumor markers were nonspecific and cannot be relied on alone to determine the origin of the primary tumor.…”

Section: Discussionmentioning

confidence: 99%

Poorly cohesive duodenal carcinoma mixed with signet ring cell carcinoma with systemic metastasis: a case report and literature review

Tang,

Li,

2023

Front. Oncol.

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Poorly cohesive duodenal carcinoma mixed with signet ring cell carcinoma is very rare, and no cases have been reported. When distant metastasis occurs, it is very easy to be misdiagnosed. We report the first case of a 52-year-old man with poorly cohesive carcinoma of the duodenum mixed with signet ring cell carcinoma with systemic metastasis. The process of its diagnosis and differential diagnosis is highlighted.

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“…Their expression has been detected mainly at the tumor level and to a markedly lesser extent as circulating molecules. SCC-A is the most studied biomarker and is overexpressed in distinct squamous cell cancers, including the following: Esophagus, lung, head, neck, and in anal canal, and uterine cervix, as well as in vulvar and penile carcinoma (101)(102)(103)(104)(105). Meanwhile, YKL-40 has demonstrated high tissue levels in anal carcinoma and it has been detected in the plasma of patients with esophageal cancer (106) and CA-125 showed relatively high circulating levels in vulvar carcinoma (107).…”

Section: Expression Of Circulating Biomarkers In Other Hpvrelated Can...mentioning

confidence: 99%

Circulating cervical cancer biomarkers potentially useful in medical attention (Review)

Garrido

Gutiérrez²,

Flores

2023

Mol Clin Oncol

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Cervical cancer (CC) is a public health problem worldwide, including Mexico. This type of cancer is the fourth most frequent in women worldwide; in Mexico it is the second most common type in women after breast cancer. The diagnosis of CC is based mainly on Pap smears and colposcopy and the identification of molecular tools that serve as a support for these methods is urgent. Regarding this, differential expressions of specific circulating biomolecules has been detected and, based on this, they have been postulated as potential biomarkers for CC diagnosis, prognosis, and/or to identify the response to treatments. Importantly, the combined analysis of these molecules considerably improves their efficacy as biomarkers and their potential use in the medical attention is promising. Contents1. Introduction 2. Proteins 3. ncRNAs 4. The estrogen effect on the expression of biomarkers 5. cDNA 6. Putative molecular mechanisms altered by the CC biomarkers 7. Circulating biomarkers expression in other HPV-related cancers 8. How feasible is it to use a test of this type in the heath sector of undeveloped countries? 9. The best biomarkers panel, according to our point of view 10. Conclusions and future directions

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Association of CEA, NSE, CYFRA 21-1, SCC-Ag, and ProGRP with Clinicopathological Characteristics and Chemotherapeutic Outcomes of Lung Cancer

Cited by 16 publications

References 22 publications

Establishment and validation of a long-term prognosis prediction model for patients with non-small cell lung cancer

Establishment and validation of a long-term prognosis prediction model for patients with non-small cell lung cancer

Poorly cohesive duodenal carcinoma mixed with signet ring cell carcinoma with systemic metastasis: a case report and literature review

Circulating cervical cancer biomarkers potentially useful in medical attention (Review)

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