Association of CDKAL1 gene rs7756992 A/G polymorphism with type 2 diabetes mellitus and diabetic nephropathy in the Egyptian population

El-Husseiny, Ahmed A.; El-Din, Ayman M. Gamal; Mariee, Amr D.; Mohamed, Ragaa R.; Ibrahiem, Amal H.

doi:10.1016/j.genrep.2017.04.003

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…A significant association was observed between the rs7756992 CDKAL1 gene variant and the risk of diabetes. Similar to our finding, individuals with rs7756992 G allele polymorphism were susceptible to diabetes [ 34 , 35 ]. In the Russian population, those who retained G/G allele of rs7756992 had higher OR 1.59 (95% CI 1.10–2.29, p -value < 0.05) compared to those who retained A/A allele [ 17 ].…”

Section: Discussionsupporting

confidence: 91%

Dietary Protein and Fat Intake Affects Diabetes Risk with CDKAL1 Genetic Variants in Korean Adults

Choi

Jin

Kim

et al. 2020

IJMS

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Cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is one of the strongest diabetes loci identified to date; evidence suggests that it plays an important role in insulin secretion. Dietary factors that affect insulin demand might enhance the risk of diabetes associated with CDKAL1 variants. Our aim was to examine the interactions between dietary protein and fat intake and CDKAL1 genetic variants in relation to the risk of diabetes in Korean adults. Single nucleotide polymorphisms (SNPs) were selected with a genome-wide association study (GWAS) for diabetes after adjustment for age, gender, and examination site. Using data from the Health Examinees (HEXA) Study of the Korean Genome and Epidemiology Study (KoGES), 3988 middle-aged Korean adults between 40–76 years of age (2034 men and 1954 women) were included in the study. Finally, rs7756992 located within the CDKAL1 gene region was selected from GWAS (p-value < 5 × 10−8). Multivariable logistic regression models were used to evaluate the interactions between genotypes and dietary protein and fat intake in relation to diabetes risk after adjustment for age, gender, BMI, waist circumference, physical activity, smoking status, drinking habits, and examination site. Significant interactions between CDKAL1 rs7756992 and dietary protein and fat intake for the risk of diabetes were observed in men (p-value < 0.05). In women, significant interactions between dietary protein and fat intake and CDKAL1 variants (rs7756992) were associated with increased risk of diabetes (p-value < 0.05). Dietary protein and fat intake interacted differently with CDKAL1 variants in relation to the risk of diabetes in Korean adults of both genders. These findings indicate that CDKAL1 variants play a significant role in diabetes and that dietary protein and fat intake could affect these associations.

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Section: Discussionsupporting

confidence: 91%