Association of cattle growth hormone gene polymorphism with milk productivity

Dolmatova, I. Yu.; Ilyasov, I. G.

doi:10.1134/s1022795411060081

Cited by 10 publications

(7 citation statements)

References 5 publications

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“…Studies in other poultries reported the associations of the GH gene with growth and carcass traits in Pitalah and Kumbang Janti Indonesian ducks (Yurnalis et al, 2017), Huoyan Chinese native goose , and Japanese quail (Johari et al, 2013). In other farm animals, the GH gene was reported in cattle breeds (Dolmatova & Ilyasov, 2011), pig (Ashok et al, 2014), salmonids fish (Kamenskaya et al, 2015), sheep (Jia et al, 2014), goat , camel (Shawki et al, 2015), and passerine bird (Arai & Iigo, 2010). The effect of GH and GHR gene polymorphisms on carcass component in Kampung and broiler chicken cross has not been examined yet.…”

Section: Introductionmentioning

confidence: 99%

The Associations of GH and GHR Genes with Carcass Components in Indonesian Kampung and Broiler Chicken Cross

Khaerunnisa

Jakaria

Arief

et al. 2017

Med Pet

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The chicken growth hormone (GH) and its receptor (growth hormone receptor, GHR) play important roles in chicken performances due to their crucial functions in growth. The variations of GH and GHR genes were then thought to be associated with the variations of the performances. This experiment was designed to identify the g.2248G>A GH and the g.565G>A GHR loci polymorphisms and to evaluate their associations with carcass components in Kampung and broiler chicken cross. A total of 215 chickens including 4 chicken populations (Kampung, Cobb broiler, F1, and F2 Kampung x broiler chicken cross) were screened to identify polymorphism using PCR-RFLP technique with EcoRV and Eco72I restriction enzyme for GH and GHR loci, respectively. The carcass components were recorded at 26 weeks of age on F2 Kampung and broiler chicken cross (42 chickens) for association study. Both the g.2248G>A GH and the g.565G>A GHR loci were polymorphic with two alleles (G and A) and three genotypes (GG, AG, and AA). The GG genotype and the G allele of GH locus were predominant in all chicken populations. While in GHR locus, the AA genotype and the A allele were found to be higher in all chicken populations. The association study showed that the g.565G>A GHR locus polymorphism had significant effect on carcass components, including live weight, carcass weight, breast weight, thighs weight, breast muscle weight, and thighs muscle weight. There was no significant association was found between the g.2248G>A GH genotype and carcass components. It could be concluded that the g.2248G>A GH and the g.565G>A GHR loci were polymorphic in Kampung and broiler chicken cross and the g.565G>A GHR locus was accosiated with carcass components. This g.565G>A GHR SNP might be an important candidate marker for chicken growth and muscle mass improvement. Keywords: Kampung chicken cross, growth hormone, growth hormone receptor, gene polymorphisms, carcass ABSTRAKHormon pertumbuhan dan reseptor hormon pertumbuhan memiliki peran penting dalam performa pertumbuhan ayam. Tujuan penelitian ini adalah mengidentifikasi keragaman gen hormon pertumbuhan (lokus g.2248G>A GH) dan gen reseptor hormon pertumbuhan (lokus g.565G>A GHR) dan mengevaluasi pengaruhnya pada komponen karkas pada ayam silangan Kampung dan broiler. Penentuan genotipe dilakukan pada 215 ekor ayam, yang terdiri atas 4 populasi (Kampung, ras pedaging strain Cobb, silangan F1 dan F2 Kampung x ras pedaging strain Cobb) menggunakan enzim pemotong EcoRV dan Eco72I masing-masing untuk fragmen lokus g.2248G>A GH dan lokus g.565G>A GHR. Analisis asosiasi dengan komponen karkas dilakukan pada populasi ayam silangan F2 Kampung x ras pedaging strain Cobb umur 26 minggu. Kedua lokus tersebut bersifat polimorfik dengan dua alel yang ditemukan (alel A dan G) dan tiga genotipe (genotipe GG, AG, dan AA). Genotipe GG dan alel G pada lokus g.2248G>A GH ditemukan dalam frekuensi tertinggi di semua populasi yang diuji. Sementara pada lokus g.565G>A GHR, genotipe AA dan alel A ditemukan paling dominan. Analisis asosiasi...

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Section: Introductionmentioning

confidence: 99%

The Associations of GH and GHR Genes with Carcass Components in Indonesian Kampung and Broiler Chicken Cross

Khaerunnisa

Jakaria

Arief

et al. 2017

Med Pet

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“…In bovine breeds, GH polymorphisms were extensively studied and some associations between production traits and polymorphism have been established (9). An association between the polymorphism observed in the exon 4 of the GH gene using the restriction enzyme Alu I and milk traits Black Pied, Bestuzhevskaya, and Simmental cattle breeds were reported (9). A positive association of polymorphism in exon 5 with selection for milk yield in Holstein cows (10).…”

mentioning

confidence: 97%

“…The polymorphisms in GH gene (exon 5 by RFLP) were also reported in the dairy cattle (8). In bovine breeds, GH polymorphisms were extensively studied and some associations between production traits and polymorphism have been established (9). An association between the polymorphism observed in the exon 4 of the GH gene using the restriction enzyme Alu I and milk traits Black Pied, Bestuzhevskaya, and Simmental cattle breeds were reported (9).…”

mentioning

confidence: 98%

Comparative Sequence Analysis in the Exon 5 of Growth Hormone Gene in the Various Livestock Species of India

Singh

Sharma

Kumari

et al. 2013

Animal Biotechnology

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The aim of the study was to identify genetic polymorphism in growth hormone (GH) gene locus of six different livestock species using PCR-Direct DNA sequencing method. In exon 5 of GH gene, 10 SNPs variants were identified in all livestock species studied, namely Bubalus bubalis, Bos indicus, Bos frontalis, Bos grunniens, Ovis aries, and Capra hircus. Four SNPs were observed in Bubalus bubalis, two SNPs in Bos indicus, one SNP in Ovis aries, and three SNPs in Capra hircus. No changes were observed in Bos grunniens and Bos frontalis when compared with the template sequence and the SNPs observed in the present investigation may be useful in the marker assisted selection.

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“…Associated with milk, fat and protein yields, and fat percentage [35][36][37] Heat shock protein 70 (Hsp70)…”

Section: Microsatellite Marker Inra111mentioning

confidence: 99%

“…The milk yield per 305 days in Holstein cows with the AA genotype was significantly higher than in cows with the GA and GG genotypes [34]. Another polymorphism associated with milk yield and milk fat and protein yields, as well as the per centage of milk fat, is located in the gene for the growth hormone GH [35][36][37]. This polymorphism is due to C>G transversion at position 2141 in GH gene, which leads to an amino acid substitution of valine to leucine at position 127 of the polypeptide and a disap pearance of the restriction site for AluI endonuclease in GH nucleotide sequence.…”

Section: A>g 17266indelcctmentioning

confidence: 99%

Molecular genetic markers of economically important traits in dairy cattle

Yudin

Воевода

2015

Russ J Genet

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The authors advise that during the study period the definition (not the evaluation) of reported udder health (UDH) changed and the scale was reversed (i.e. the negative (-) associated with UDH should be positive (+) and vice versa). However, this correction was omitted in a few places in the published paper. Therefore, the correct text in the 'Expected genetic changes under selection scenarios' section should read: A relative weight of 25% of PME (selection scenario IV) generated a response of PME

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Association of cattle growth hormone gene polymorphism with milk productivity

Cited by 10 publications

References 5 publications

The Associations of GH and GHR Genes with Carcass Components in Indonesian Kampung and Broiler Chicken Cross

The Associations of GH and GHR Genes with Carcass Components in Indonesian Kampung and Broiler Chicken Cross

Comparative Sequence Analysis in the Exon 5 of Growth Hormone Gene in the Various Livestock Species of India

Molecular genetic markers of economically important traits in dairy cattle

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