Association of Cardiovascular Risk Factors and Endothelial Dysfunction in Japanese Hypertensive Patients: Implications for Early Atherosclerosis.

Furumoto, Tomoo; Saito, Naotaka; Dong, Jie; Mikami, Taisiei; Fujii, Satoshi; Kitabatake, Akira

doi:10.1291/hypres.25.475

Cited by 73 publications

(51 citation statements)

References 27 publications

(22 reference statements)

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“…Type 2 diabetes may cause endothelial dysfunction through hyperglycemia, hyperinsulinemia and lipid disorders (24). Traditional coronary risk factors such as hypertension, hypercholesterolemia, diabetes, increased age, obesity, and cigarette smoking have been shown to contribute to endothelial dysfunction in coronary and peripheral vessels (25,26), but, except for diabetes, these effects were not observed in this study population. In the present study, many risk factors were not simply present or absent, treated or untreated, but rather were present to a greater or lesser degree.…”

Section: Fmd In the Brachial Arteries And Coronary Vasomotor Responsementioning

confidence: 63%

Brachial Artery Flow-Mediated Vasodilation Is Correlated with Coronary Vasomotor and Fibrinolytic Responses Induced by Bradykinin

et al. 2005

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Section: Fmd In the Brachial Arteries And Coronary Vasomotor Responsementioning

confidence: 63%

Brachial Artery Flow-Mediated Vasodilation Is Correlated with Coronary Vasomotor and Fibrinolytic Responses Induced by Bradykinin

et al. 2005

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“…Previous studies have reported conflicting results about the relationship between IL-6 and HBP. 3,5,9,10,12,13,21,22 With one exception, 10 these studies were not designed to test the association between IL-6 and HBP, and failed to control for other cardiovascular risk factors. In fact, our results are consistent with those from the study of Chae et al, 10 the only other study in which appropriate control of confounding factors has been conducted.…”

Section: Discussionmentioning

confidence: 99%

“…30 Therefore, IL-6 may result in elevated BP by inducing endothelial dysfunction and increasing peripheral vascular resistance. 31,32 Some reports of studies in human subjects have shown a significant association between TNF-a and elevated BP, 11,12,21 but others have failed to show such an association. 13,14 Unfortunately, none of these studies has been designed to test this hypothesis and all have failed to control for other risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8] On the other hand, results from studies on the association between interleukin-6 (IL-6) and HBP have been contradictory. 9,10 Similarly, some studies in human subjects have shown a positive association between tumour necrosis factor alpha (TNF-a) level and HBP, 11,12 but others have not. 13,14 However, most of these studies were not designed to test the association between inflammation markers and HBP and have failed to control for other risk factors for HBP and for other inflammatory markers.…”

Section: Introductionmentioning

confidence: 99%

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Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-α) and essential hypertension

et al. 2004

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High blood pressure (HBP) has been associated with elevated C-reactive protein (CRP), a marker of chronic mild inflammation. However, the association between HBP and other inflammatory markers, particularly interleukin 6 (IL-6) and tumour necrosis alpha (TNF-a), has not been evaluated in well-controlled studies. We examined the cross-sectional relationship between IL-6, TNF-a, and CRP and HBP in a random sample of 196 healthy subjects. All markers were measured in duplicate with high-sensitivity ELISA tests. Three blood pressure (BP) measurments were averaged for the analysis, and subjects with systolic BP X140 and/or diastolic BP X90 mmHg were considered hypertensive. Log binomial regression was used to estimate multivariate-adjusted prevalence ratios (PR) of HBP. Of the subjects, 40% (79) were hypertensive (mean age: 44 years; range 30-64). After adjustment for age, sex, body mass index, family history of HBP, and the level of the other inflammatory markers, subjects in the second (PR: 3.10, P ¼ 0.003), third (PR: 2.32; P ¼ 0.031), and fourth quartiles (PR: 2.30; P ¼ 0.036) of IL-6 were more than twice as likely to be hypertensive than those in the first quartile. Corresponding PR estimates for TNF-a levels were 1.41 (P ¼ 0.014) for the second; 1.59 (P ¼ 0.001) for the third; and 1.61 (P ¼ 0.025) for the fourth quartile. The CRP-HBP association was not statistically significant. Our results suggest that TNF-a and IL-6 could be independent risk factors for HBP in apparently healthy subjects. Nevertheless, the temporal relationship between elevated inflammation markers and HBP should be ascertained in prospective cohort studies.

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“…8,16 All of the patients in this study had endothelial cell dysfunction at baseline as a result of hypertension, as has been demonstrated in previous reports. 6,7 However, endothelial cell dysfunction significantly improved in approximately half of the patients after treatment. Moreover, the low-dose perindopril-indapamide combination improved left ventricular diastolic function parameters (ie, IVRT and EDT).…”

Section: Discussionmentioning

confidence: 99%

Effects of low-dose combination therapy with an angiotensin-converting enzyme inhibitor and a diuretic on flow-mediated vasodilation in hypertensive patients: a 6-month, single-center study

Seküri

Bayturan

Göçer

et al. 2003

Current Therapeutic Research

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Background: Combination therapy with an angiotensin-converting enzyme (ACE) inhibitor and a diuretic has been shown to be highly effective in hypertension. Clinical trials have demonstrated that ACE inhibitors may improve endothelial cell dysfunction in hypertension. However, the effectiveness of the combination treatment in endothelial cell dysfunction is unknown.Objective: This study investigated the effects of a new low-dose combination, perindopril 2 mg plus indapamide 0.625 mg, on brachial artery flow-mediated vasodilation (FMD) and left ventricular diastolic function in hypertension.Methods: Patients aged 18 to 75 with newly diagnosed stage I or II hypertension were eligible. Endothelium-dependent brachial artery FMD and endotheliumindependent vasodilation were assessed at baseline. Patients were treated with oral perindopril 2 mg plus indapamide 0.625-mg tablets once daily for 6 months. FMD measurements were then repeated. Percentage changes in FMD from baseline to 6 months, as well as left ventricular diastolic function parameters (isovolumic relaxation time [IVRT] and mitral diastolic E-wave deceleration time [EDT]), indicated the effectiveness of the intervention.Results: Twenty-nine Turkish patients were enrolled (17 women, 12 men; mean [SD] age, 54.5 [9.5] years [range, 38-75 years]). The mean (SD) baseline FMD was 7.00% (2.39%) (endothelial cell dysfunction) and increased significantly to 8.68% (2.78%) at 6 months (P ϭ 0.02); FMD improved in 15 patients (51.7%). At baseline and 6 months of therapy, mean (SD) IVRT was 101.7 (12.4) ms and 95.5 (7.7) ms, respectively (P Ͻ 0.001), and EDT was 234.7 (33.9) ms and 217.9 (25.6) ms, respectively (P Ͻ 0.001).Conclusions: In this small sample of hypertensive patients, a low-dose combination ACE inhibitor and diuretic significantly improved brachial artery FMD Accepted for publication October 16, 2003October 16, . doi:10.1016October 16, /j.curtheres.2003.005 Reproduction in whole or part is not permitted.0011-393X/03/$19.00Copyright ą 2003 Excerpta Medica, Inc. CURRENT THERAPEUTIC RESEARCHand left ventricular diastolic function. The improvement in FMD values was independent of the stage of hypertension. These findings suggest a relationship between improvement in endothelial cell function and diastolic function. (Curr Ther Res Clin Exp. 2003;64:715-724)

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Association of Cardiovascular Risk Factors and Endothelial Dysfunction in Japanese Hypertensive Patients: Implications for Early Atherosclerosis.

Cited by 73 publications

References 27 publications

Brachial Artery Flow-Mediated Vasodilation Is Correlated with Coronary Vasomotor and Fibrinolytic Responses Induced by Bradykinin

Brachial Artery Flow-Mediated Vasodilation Is Correlated with Coronary Vasomotor and Fibrinolytic Responses Induced by Bradykinin

Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-α) and essential hypertension

Effects of low-dose combination therapy with an angiotensin-converting enzyme inhibitor and a diuretic on flow-mediated vasodilation in hypertensive patients: a 6-month, single-center study

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