Association of cadmium with renal cancer

Kolonel, Laurence N.

doi:10.1002/1097-0142(197604)37:4<1782::aid-cncr2820370424>3.0.co;2-f

Cited by 199 publications

(64 citation statements)

References 17 publications

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“…Coke oven workers have also been reported to be at increased risk (20). Cadmium has been linked to an increased risk of renal cell cancer in one early study (21), but has not been associated in later, larger case-control studies or in occupational cohort investigations (1). Inorganic lead has induced renal tumors in laboratory animals, although there is no epidemiologic support for an association in humans (22).…”

Section: Risk Factorsmentioning

confidence: 99%

Renal cell cancer and exposure to gasoline: a review.

McLaughlin

1993

Environ Health Perspect

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A review of the epidemiology of renal cell cancer is presented. Risk factors for renal cell cancer such as cigarette smoking, obesity, diet, and use of analgesics and prescription diuretics are examined. Although uncommon, occupational risk factors are also reviewed. Studies examining gasoline exposure and renal cell cancer are evaluated, including investigations recently presented at a meeting on this topic. Overall, most studies find no link between gasoline exposure and renal cell cancer; moreover, the experimental evidence that initiated the health concern is no longer considered relevant to humans. Positive associations, however, reported in two recent studies prevent a firm conclusion of no risk for this exposure.

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Section: Risk Factorsmentioning

confidence: 99%

Renal cell cancer and exposure to gasoline: a review.

McLaughlin

1993

Environ Health Perspect

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“…In rats, the number of tumors induced by dimethylnitrosamine was enhanced by subsequent treatment with CdCl2 (13). Several epidemiological studies point toward a higher frequency of tumors of exposed humans (14)(15)(16) and an increased incidence of renal cancer in smokers (17). A recent follow up of one of the studies (14) in a cadmium smelter in the United States confirmed a statistically significant excess in mortality from lung cancer (18,19).…”

Section: Introductionmentioning

confidence: 99%

Role of DNA Repair Inhibition in Lead- and Cadmium-Induced Genotoxicity: A Review

Hartwig¹

1994

Environmental Health Perspectives

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Compounds of lead and cadmium have been shown to be carcinogenic to humans and experimental animals. However, the underlying mechanisms are still not understood. In mammalian cells in culture, lead(lIl) is weakly mutagenic after long incubation times and generates DNA strand breaks only after treatment with high, toxic doses. Cadmium(ll) induces DNA strand breaks and chromosomal aberrations, but its mutagenic potential is rather weak. However, both metals exert pronounced indirect genotoxic effects. Lead(ll) is comutagenic towards UV and N-methyl-N-nitro-Nnitrosoguanidine (MNNG) and enhances the number of UV-induced sister chromatid exchanges in V79 Chinese hamster cells. With regard to DNA repair, lead(ll) causes an accumulation of DNA strand breaks after UV-irradiation in HeLa cells, indicating an interference with the polymerization or ligation step in excision repair. Cadmium(ll) enhances the mutagenicity of UV light in V79 Chinese hamster cells and an increased sensitivity toward UV light is observed in various rodent and human cell lines. Furthermore, an inhibition of unscheduled DNA synthesis after UV-irradiation and a partial inhibition of the removal of UV-induced DNA lesions has been shown. For both metals, the indirect genotoxic effects are observed at low, nontoxic concentrations, suggesting that an interference with DNA repair processes may be predominant at biologically relevant concentrations. This might also explain the conflicting results of epidemiological studies obtained for both metals. Possible mechanisms of repair inhibiton are discussed.-Environ Health Perspect 102(Suppl 3): 45-50 (1994).

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“…Epidemiologic and experimental evidence has brought forth hypotheses on pr esumed work-related determinants of renal cell cancer. Those of primary concern are various hydrocarbon derivatives (24)(25)(26), petrochemical s and gasoline, jet fuel and other products of petroleum refining (16,(27)(28)(29); gasoline exhaust (18,30); cadmium (31); inorganic lead compounds (10,32); and asbestos (21,22,33).…”

mentioning

confidence: 99%

Renal cell cancer and occupational exposure to chemical agents.

Partanen¹,

Heikkilä²,

Hernberg³

et al. 1991

Scand J Work Environ Health

150

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PARTANEN T, HEIKKILA P, HERNBERG S, KAUPPINEN T, MONETA G, OJAJARVI A. Renal cell cancer and occupational exposure to chemical agents. Scand J Work En viron Health 1991; 17:231-9. A case-referent study of occupational risk indicators of renal cell adenocarcinoma was conducted. Each incident case in Finland in 1977-1978 was matched with two population referents. Lifelongjob histories were collected and translated into indicators of industry, occupation, and occupational exposures. The analyses of 338 sets of cases and referents revealed elevated risks for a history of employment in whitecollar occupations; the printing industry; the chemical industry; the manufacturing of metal products; mail, telephone, and telegraph services; and iron and metalware work. A decreased risk was observed for male farmers. An elevated risk and an exposure-response relationship were found for gasoline exposure. The excess risk was highest at a latency period of approximately 30 years. The findings support the hypothesisthat exposureto some constituent(s) of gasolineincreases the incidenceof renal adenocarcinoma in humans. Suggestions of elevated risks appeared for exposures to inorganic lead, cadmium, and nonchlorinated solvents.

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Association of cadmium with renal cancer

Cited by 199 publications

References 17 publications

Renal cell cancer and exposure to gasoline: a review.

Renal cell cancer and exposure to gasoline: a review.

Role of DNA Repair Inhibition in Lead- and Cadmium-Induced Genotoxicity: A Review

Renal cell cancer and occupational exposure to chemical agents.

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