Association of C-Reactive Protein-to-Albumin Ratio With the Presence and Progression of Abdominal Aortic Aneurysm

Abstract

Aortic dilatation due to inflammation may lead to an increase in C-reactive protein (CRP) levels. We investigated the possible relationship between CRP-to-albumin ratio (CAR) and presence and progression of abdominal aortic aneurysms (AAAs). The study included 150 patients previously diagnosed with AAA (diameter 40-54 mm) and 100 normal controls. Clinical and laboratory parameters and maximal cross-sectional AAA diameters (measured by computed tomography angiography) were obtained from all participants at baseline assessment as well as after 1 year for those with an AAA. The patients with AAA had significantly higher serum CAR compared with controls at baseline (P < .001). Increased serum CAR was found to be an independent predictor of the presence of AAA (odds ratio: 3.162, 95% CI: 1.690-5.126, P = .001) after multivariate logistic regression analysis. There was a significant increase in aortic diameter and CAR after 1 year in the patients with AAA ( P < .001; P = .003); a significant correlation was found between changes in the diameter of AAAs and CAR ( r = 0.414; P = .005). Serum CAR may be useful as an inflammatory biomarker for the presence and progression of AAA.

Reply to the Letter to the Editor Entitled “C-Reactive Protein-to-Albumin Ratio and Progression of Abdominal Aortic Aneurysm”

“…Additionally, they 1 mention that there is no information about medication in our study. 2 As noted in the results section of our study, 2 statin use was similar between the 2 groups.…”

C-Reactive Protein-to-Albumin Ratio and Progression of Abdominal Aortic Aneurysm

“…Statins can reduce CRP levels by up to 60% 10 and decrease inflammatory markers such as NLR. 2 These effects could affect the results of the study by Cersit et al 1…”

“…We read the article “Association of C-Reactive Protein-to-Albumin Ratio With the Presence and Progression of Abdominal Aortic Aneurysm” by Cersit et al with interest. 1 They found a significant correlation between changes in the diameter of abdominal aortic aneurysms (AAAs) and C-reactive protein-to-albumin ratio (CAR).…”

“…2 –6 In this study, these markers did not show significant relationships between changes in the diameter of AAAs. 1 However, Vuruskan et al showed that white blood cells (WBC), NLR, and total and direct bilirubin levels were independent predictors of the presence of an AAA, and also they found that WBC and total bilirubin level were independent predictors of a rapidly enlarging AAA. 7…”

“…Additionally, Cersit et al 1 mentioned the positive effects of statins on AAAs, probably via pleiotropic effects. They stated that statins have an anti-inflammatory action, and this may inhibit the expansion of aneurysms and improve survival after AAA repair.…”