Reply to the Letter to the Editor Entitled “C-Reactive Protein-to-Albumin Ratio and Progression of Abdominal Aortic Aneurysm”

Abstract

We thank Gayretli Yayla et al 1 for their interest in our study. 2 They mention that several inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), and monocyte to high-density lipoprotein cholesterol ratio (MHDLCR), did not show significant relationships with changes in the diameter of abdominal aortic aneurysm (AAA) in our study.Our patients with AAA had significantly higher serum C-reactive protein to albumin ratio (CAR), C-reactive protein, white blood cell (WBC) count, and neutrophil count compared with controls at baseline. 2 However, significant changes were not observed in these parameters, except for the serum CAR after 1 year in patients with AAA. White blood cell and neutrophil counts, NLR, PLR, MLR, and MHDLCR are widely used laboratory parameters to evaluate the inflammatory process. 3,4 Elevated WBC and neutrophil counts and NLR values also correlate with in-hospital mortality and an increased risk of rupture of AAAs. 4 In another study, although a high NLR correlated well with the presence of AAA, it was not an independent predictor of the enlargement rate. 5 In our study, the patients with AAA had significantly higher WBC and neutrophil counts when compared with controls at baseline, but nonsignificant changes were observed in these parameters after 1 year.Additionally, they 1 mention that there is no information about medication in our study. 2 As noted in the results section of our study, 2 statin use was similar between the 2 groups. ORCID iDs