Association of breast and colorectal cancer in patients with central centrifugal cicatricial alopecia: A retrospective, cross-sectional pilot study

Brown-Korsah, Jessica; Roche, Fritzlaine C.; Taylor, Susan C.

doi:10.1016/j.jaad.2020.10.044

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…A 4.68× increase in the odds of having uterine leiomyomas compared with race-, age-, and sex-matched controls was also observed in a retrospective study at Johns Hopkins Hospital (p < 0.001) [24]. Additionally, Brown et al demonstrated that in patients with biopsy-proven CCCA (159 of 742), 4.4% had a history of breast cancer compared with the 4079 controls (1.8%) (odds ratio 2.49; 95% confidence interval 1.06-4.92; p = 0.02) [25]. Both latter conditions are associated with an abnormal proliferation of fibrous tissue and once again demonstrate a crossover of the pathogenesis to different organ systems.…”

Section: Clinical Associationsmentioning

confidence: 72%

“…Both latter conditions are associated with an abnormal proliferation of fibrous tissue and once again demonstrate a crossover of the pathogenesis to different organ systems. The average age of diagnosis of breast cancer was 62.9 years [25]. While the types of breast cancer were not delineated in the study, an association between dysregulated PADI3, upregulated MMP9, triple-negative inflammatory breast cancer (TNIBC), and triple-negative non-inflammatory breast cancer (TN-NIBC) has been documented in the literature [5,6,23].…”

Section: Clinical Associationsmentioning

confidence: 88%

“…Women who have the gene change BRCA1 are also more likely to develop TNBC than other women [26]. Further investigation is therefore needed into the types of breast cancer diagnosed in the retrospective cross-sectional study by Brown et al, as it may help to broaden the scope of associated genetic markers to screen in the younger population [25].…”

Section: Clinical Associationsmentioning

confidence: 99%

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Central Centrifugal Cicatricial Alopecia in the Adolescent Population: An Overview of Available Literature

Palmer

Valdebran

2023

Life

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Central centrifugal cicatricial alopecia (CCCA) is a lymphocytic scarring alopecia that predominantly affects women of African descent. Recent studies have demonstrated prevalence in children and adolescents, as well as Asian populations. A thorough search of Pubmed, Cochrane Database of Systematic Reviews, OVID Medline and Google Scholar was conducted using keywords such as “central centrifugal cicatricial alopecia”, “scarring hair loss”, “scarring alopecia”, “hot comb alopecia”, “pediatric” and “adolescent”. The results yielded few articles in the literature that directly addressed CCCA in the adolescent population, with three articles providing details of the presentation in the form of case series and retrospective reviews. The presentation in the adolescent population was found to be varied, ranging from asymptomatic to symptomatic and involving diffuse to patchy hair loss in only the vertex and/or frontal and parietal scalp. Genetic and environmental etiologies were found to be statistically significant, and markers of metabolic dysregulation predisposing patients to diabetes mellitus and breast cancer were also uncovered. The differential diagnosis of patients who present with hair loss in the adolescent population should therefore be broad, and a low threshold for biopsies should be adopted to confirm CCCA in suspected patients. This will have future implications for reduced morbidity and public health.

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Section: Clinical Associationsmentioning

confidence: 72%

Section: Clinical Associationsmentioning

confidence: 88%

Section: Clinical Associationsmentioning

confidence: 99%

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Central Centrifugal Cicatricial Alopecia in the Adolescent Population: An Overview of Available Literature

Palmer

Valdebran

2023

Life

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“…Brown-Korsah et al 19 looked at the risk of colorectal and breast cancers in patients with CCCA. All Black women 18 years or older with a biopsy-proven diagnosis of CCCA were included in the retrospective chart review.…”

Section: Resultsmentioning

confidence: 99%

Risk factors and comorbidities associated with central centrifugal cicatricial alopecia

Green,

Feschuk,

Valdebran

2023

International Journal of Women’s Dermatology

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Central centrifugal cicatricial alopecia (CCCA) is the most common form of scarring alopecia that most often affects Black women. The disease typically begins with hair loss in the center scalp, which progresses in a centripetal fashion. Both environmental insult and genetics have been implicated in CCCA etiology, although the exact pathophysiology remains unknown. Nevertheless, it is important that providers feel comfortable educating their patients on risk factors (RFs) for the development or worsening of CCCA, and potential comorbidities associated with the condition. Thus, the goal of this review was to summarize these factors. A comprehensive literature search was performed, and studies were included if they reported research on RFs for or comorbidities associated with, CCCA. A total of 15 studies were included: n = 5 researching RFs for CCCA and n = 10 researching comorbidities associated with CCCA. There was an association suggesting an increased risk of CCCA with traction hairstyles in n = 2/3 studies, previous pregnancies in n = 1/1 studies, and use of chemical hair relaxers in n = 1/3 studies. Additionally, age and total years of hair loss were associated with increased CCCA severity in n = 2/2 studies. Type 2 diabetes was positively associated with CCCA in n = 3/5 studies, uterine leiomyomas in n = 1/2 studies, hyperlipidemia in n = 1/2 studies, and vitamin D deficiency in n = 1/1 studies. Conflicting results regarding RFs and comorbidities associated with CCCA exist within the literature. Thus, further investigation in larger cohorts must be done, and future research into genes implicated in CCCA and their potential role in the development of other diseases is recommended.

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Beyond the Hot Comb: Updates in Epidemiology, Pathogenesis, and Treatment of Central Centrifugal Cicatricial Alopecia from 2011 to 2021

et al. 2022

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Association of breast and colorectal cancer in patients with central centrifugal cicatricial alopecia: A retrospective, cross-sectional pilot study

Abstract: Funding sources: None. Conflicts of interest: None disclosed. IRB approval status: Reviewed and approved by the University of Pennsylvania IRB (834059).

Cited by 6 publications

References 5 publications

Central Centrifugal Cicatricial Alopecia in the Adolescent Population: An Overview of Available Literature

Central Centrifugal Cicatricial Alopecia in the Adolescent Population: An Overview of Available Literature

Risk factors and comorbidities associated with central centrifugal cicatricial alopecia

Beyond the Hot Comb: Updates in Epidemiology, Pathogenesis, and Treatment of Central Centrifugal Cicatricial Alopecia from 2011 to 2021

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