Beyond the Hot Comb: Updates in Epidemiology, Pathogenesis, and Treatment of Central Centrifugal Cicatricial Alopecia from 2011 to 2021

George, Elisabeth A.; Matthews, Caneisaya; Roche, Fritzlaine C.; Taylor, Susan C.

doi:10.1007/s40257-022-00740-w

Cited by 8 publications

(20 citation statements)

References 61 publications

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“…This is in keeping with other average ages of primary cicatricial alopecias [11]. Concurrent psychiatric co-morbidities included anxiety (22.2%) and depression (22.2%) [9,11].…”

Section: Epidemiologysupporting

confidence: 87%

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Central Centrifugal Cicatricial Alopecia in the Adolescent Population: An Overview of Available Literature

Palmer

Valdebran

2023

Life

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Central centrifugal cicatricial alopecia (CCCA) is a lymphocytic scarring alopecia that predominantly affects women of African descent. Recent studies have demonstrated prevalence in children and adolescents, as well as Asian populations. A thorough search of Pubmed, Cochrane Database of Systematic Reviews, OVID Medline and Google Scholar was conducted using keywords such as “central centrifugal cicatricial alopecia”, “scarring hair loss”, “scarring alopecia”, “hot comb alopecia”, “pediatric” and “adolescent”. The results yielded few articles in the literature that directly addressed CCCA in the adolescent population, with three articles providing details of the presentation in the form of case series and retrospective reviews. The presentation in the adolescent population was found to be varied, ranging from asymptomatic to symptomatic and involving diffuse to patchy hair loss in only the vertex and/or frontal and parietal scalp. Genetic and environmental etiologies were found to be statistically significant, and markers of metabolic dysregulation predisposing patients to diabetes mellitus and breast cancer were also uncovered. The differential diagnosis of patients who present with hair loss in the adolescent population should therefore be broad, and a low threshold for biopsies should be adopted to confirm CCCA in suspected patients. This will have future implications for reduced morbidity and public health.

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“…This is in keeping with other average ages of primary cicatricial alopecias [11]. Concurrent psychiatric co-morbidities included anxiety (22.2%) and depression (22.2%) [9,11].…”

Section: Epidemiologysupporting

confidence: 87%

“…Women of African descent have a higher predilection for the condition, with a female: male ratio of 3:1 [8]. Adolescent patients tend to have a late presentation, like their adult counterparts [9]. Six patients with biopsy-proven cases of CCCA had an average of 32.4 months from symptom onset to presentation [10].…”

Section: Epidemiologymentioning

confidence: 99%

Central Centrifugal Cicatricial Alopecia in the Adolescent Population: An Overview of Available Literature

Palmer

Valdebran

2023

Life

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“…Falknor described needling as one of the treatment modalities for warts in 1969. 1 Since then, there have been few studies on needling for the treatment of warts. We thank the authors for studying its role in genital warts.…”

Section: Tejas P Joshimentioning

confidence: 99%

“…Comorbidities in patients with central centrifugal cicatricial alopecia: a case-control study Dear Editor, Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia that is most prevalent among middle-aged African American women, the cause of which is debated. 1 The burden of comorbid disease in CCCA patients represents a knowledge gap for dermatologists, with current literature being limited to small studies often presenting contradictory findings. 2,3 Here, we investigate comorbidities associated with CCCA using the National Institute of Health's All of Us research program, a recently launched database that aims to collect health data on over 1 million Americans, with an emphasis on recruiting diverse communities historically underrepresented in research.…”

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confidence: 99%

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Comorbidities in patients with central centrifugal cicatricial alopecia: a case–control study

Joshi,

Duruewuru,

Garcia

et al. 2023

Int J Dermatology

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we did not prefer infliximab. 3 A case of FSGS without Ig deposition whose psoriasis and nephropathy regressed with secukinumab was reported in the literature. 7 The other reported case developed IgAN in the 5th month of secukinumab treatment, and proteinuria improved after tonsillectomy and pulse steroid therapy without discontinuation of treatment. The authors attributed the nephropathy to obesity and metabolic syndrome developed due to lifestyle changes of the patient, not due to secukinumab because proteinuria regressed despite continued treatment. 8 IL17, one of the key cytokines in psoriasis pathogenesis, increases the release of proinflammatory cytokines in patients with IgAN, increases IgA1 production by stimulating B lymphocytes, leads to underglycosylation of IgA1. Additionally, higher IL17A levels were detected in the urine and serum of IgAN patients. Therefore, IL-17 blocking can be an effective agent in the treatment of IgAN. 7,8 The effectiveness and safety of secukinumab in psoriasis with IgAN require confirmation by long-term follow-up studies of more patients. Our successful treatment of a patient provides a reference for the future treatment of such patients.

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Treatment of Common Dermatologic Conditions

Tan,

Vary,

O’Connor

2024

Medical Clinics of North America

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Beyond the Hot Comb: Updates in Epidemiology, Pathogenesis, and Treatment of Central Centrifugal Cicatricial Alopecia from 2011 to 2021

Cited by 8 publications

References 61 publications

Central Centrifugal Cicatricial Alopecia in the Adolescent Population: An Overview of Available Literature

Central Centrifugal Cicatricial Alopecia in the Adolescent Population: An Overview of Available Literature

Comorbidities in patients with central centrifugal cicatricial alopecia: a case–control study

Treatment of Common Dermatologic Conditions

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